Neonatal xenoestrogen exposure alters growth hormone-dependent liver proteins and genes in adult female rats

The hypothalamic-growth hormone (GH)-liver axis represents a new concept in endocrine regulation of drug toxicity. Preponderant sex differences are found in liver gene expression, mostly dependent on the sexually dimorphic pattern of GH secretion which is set during the neonatal period by gonadal st...

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Autores principales:	Ramirez, M.C., Bourguignon, N.S., Bonaventura, M.M., Lux-Lantos, V., Libertun, C., Becu-Villalobos, D.
Formato:	JOUR
Materias:	Bisphenol Cyps Growth hormone Liver Prolactin Sexual dimorphism 4,4' isopropylidenediphenol alcohol dehydrogenase castor oil complementary DNA cytochrome P450 2C11 cytochrome P450 2C12 endocrine disruptor glyceraldehyde 3 phosphate dehydrogenase growth hormone liver enzyme messenger RNA prolactin prolactin receptor RNA somatomedin C unclassified drug xenoestrogen animal experiment animal tissue article controlled study detoxification electrophoresis environmental exposure gene expression growth hormone release hormone blood level hypothalamus liver liver metabolism mouse newborn nonhuman perinatal period polyacrylamide gel electrophoresis priority journal protein urine level radioimmunoassay real time polymerase chain reaction Age Factors Aging Alcohol Dehydrogenase Animals Animals, Newborn Aryl Hydrocarbon Hydroxylases Drug Administration Schedule Electrophoresis, Polyacrylamide Gel Endocrine Disruptors Estrogens, Non-Steroidal Female Gene Expression Regulation, Developmental Gene Expression Regulation, Enzymologic Growth Hormone Hepatocyte Nuclear Factor 6 Injections, Subcutaneous Insulin-Like Growth Factor I Male Phenols Pituitary Gland Rats Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction Receptors, Prolactin RNA, Messenger Sex Characteristics Sex Factors Steroid 16-alpha-Hydroxylase Steroid Hydroxylases Rattus
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03784274_v213_n3_p325_Ramirez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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