Effects of sarcoma 180 growth on interleukin-1 and circulating immune complexes

Cultured splenic mononuclear adherent cells (SMAc) from normal BALB/c mice as well as those from mice bearing 10-day sarcoma 180 (S180), exhibited a marked increase in Escherichia coli lipopolysaccharide-stimulated interleukin-1 (IL-1) production, when compared to spontaneous values. On days 20 and...

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Detalles Bibliográficos
Autores principales: Chasseing, N.A., Eugui, E.M., Borda, E.S., Rumi, L.
Formato: JOUR
Materias:
escherichia coli lipopolysaccharide
interleukin 1
prostaglandin e2
animal cell
animal experiment
animal model
antigen antibody complex
article
cancer growth
carcinogenesis
controlled study
female
host resistance
immunomodulation
mononuclear cell
mouse
nonhuman
priority journal
sarcoma cell
tumor immunity
Animal
Antigen-Antibody Complex
Cell Adhesion
Cell Division
Dinoprostone
Escherichia coli
Evaluation Studies
Female
Interleukin-1
Lipopolysaccharides
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Monocytes
Neoplasm Transplantation
Sarcoma 180
Spleen
Support, Non-U.S. Gov't
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_07357907_v12_n4_p390_Chasseing
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_07357907_v12_n4_p390_Chasseing
record_format dspace
spelling todo:paper_07357907_v12_n4_p390_Chasseing2023-10-03T15:37:46Z Effects of sarcoma 180 growth on interleukin-1 and circulating immune complexes Chasseing, N.A. Eugui, E.M. Borda, E.S. Rumi, L. escherichia coli lipopolysaccharide interleukin 1 prostaglandin e2 animal cell animal experiment animal model antigen antibody complex article cancer growth carcinogenesis controlled study female host resistance immunomodulation mononuclear cell mouse nonhuman priority journal sarcoma cell tumor immunity Animal Antigen-Antibody Complex Cell Adhesion Cell Division Dinoprostone Escherichia coli Evaluation Studies Female Interleukin-1 Lipopolysaccharides Mice Mice, Inbred BALB C Mice, Inbred C3H Monocytes Neoplasm Transplantation Sarcoma 180 Spleen Support, Non-U.S. Gov't Cultured splenic mononuclear adherent cells (SMAc) from normal BALB/c mice as well as those from mice bearing 10-day sarcoma 180 (S180), exhibited a marked increase in Escherichia coli lipopolysaccharide-stimulated interleukin-1 (IL-1) production, when compared to spontaneous values. On days 20 and 30 following S180 challenge, a decrease in this effect on IL-1 production in treated and untreated SMAc was observed. Concomitantly with the alterations in the regulation of IL-1 production during tumor growth, an increase in the levels of prostaglandin E2 and serum immune complexes could be detected. These data suggest that the immunosuppression associated with later stages of tumor development may be due to direct effects on monocytes, by means of a down-regulation of IL-1 production. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_07357907_v12_n4_p390_Chasseing
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic escherichia coli lipopolysaccharide
interleukin 1
prostaglandin e2
animal cell
animal experiment
animal model
antigen antibody complex
article
cancer growth
carcinogenesis
controlled study
female
host resistance
immunomodulation
mononuclear cell
mouse
nonhuman
priority journal
sarcoma cell
tumor immunity
Animal
Antigen-Antibody Complex
Cell Adhesion
Cell Division
Dinoprostone
Escherichia coli
Evaluation Studies
Female
Interleukin-1
Lipopolysaccharides
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Monocytes
Neoplasm Transplantation
Sarcoma 180
Spleen
Support, Non-U.S. Gov't
spellingShingle escherichia coli lipopolysaccharide
interleukin 1
prostaglandin e2
animal cell
animal experiment
animal model
antigen antibody complex
article
cancer growth
carcinogenesis
controlled study
female
host resistance
immunomodulation
mononuclear cell
mouse
nonhuman
priority journal
sarcoma cell
tumor immunity
Animal
Antigen-Antibody Complex
Cell Adhesion
Cell Division
Dinoprostone
Escherichia coli
Evaluation Studies
Female
Interleukin-1
Lipopolysaccharides
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Monocytes
Neoplasm Transplantation
Sarcoma 180
Spleen
Support, Non-U.S. Gov't
Chasseing, N.A.
Eugui, E.M.
Borda, E.S.
Rumi, L.
Effects of sarcoma 180 growth on interleukin-1 and circulating immune complexes
topic_facet escherichia coli lipopolysaccharide
interleukin 1
prostaglandin e2
animal cell
animal experiment
animal model
antigen antibody complex
article
cancer growth
carcinogenesis
controlled study
female
host resistance
immunomodulation
mononuclear cell
mouse
nonhuman
priority journal
sarcoma cell
tumor immunity
Animal
Antigen-Antibody Complex
Cell Adhesion
Cell Division
Dinoprostone
Escherichia coli
Evaluation Studies
Female
Interleukin-1
Lipopolysaccharides
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Monocytes
Neoplasm Transplantation
Sarcoma 180
Spleen
Support, Non-U.S. Gov't
description Cultured splenic mononuclear adherent cells (SMAc) from normal BALB/c mice as well as those from mice bearing 10-day sarcoma 180 (S180), exhibited a marked increase in Escherichia coli lipopolysaccharide-stimulated interleukin-1 (IL-1) production, when compared to spontaneous values. On days 20 and 30 following S180 challenge, a decrease in this effect on IL-1 production in treated and untreated SMAc was observed. Concomitantly with the alterations in the regulation of IL-1 production during tumor growth, an increase in the levels of prostaglandin E2 and serum immune complexes could be detected. These data suggest that the immunosuppression associated with later stages of tumor development may be due to direct effects on monocytes, by means of a down-regulation of IL-1 production. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
format JOUR
author Chasseing, N.A.
Eugui, E.M.
Borda, E.S.
Rumi, L.
author_facet Chasseing, N.A.
Eugui, E.M.
Borda, E.S.
Rumi, L.
author_sort Chasseing, N.A.
title Effects of sarcoma 180 growth on interleukin-1 and circulating immune complexes
title_short Effects of sarcoma 180 growth on interleukin-1 and circulating immune complexes
title_full Effects of sarcoma 180 growth on interleukin-1 and circulating immune complexes
title_fullStr Effects of sarcoma 180 growth on interleukin-1 and circulating immune complexes
title_full_unstemmed Effects of sarcoma 180 growth on interleukin-1 and circulating immune complexes
title_sort effects of sarcoma 180 growth on interleukin-1 and circulating immune complexes
url http://hdl.handle.net/20.500.12110/paper_07357907_v12_n4_p390_Chasseing
work_keys_str_mv AT chasseingna effectsofsarcoma180growthoninterleukin1andcirculatingimmunecomplexes
AT euguiem effectsofsarcoma180growthoninterleukin1andcirculatingimmunecomplexes
AT bordaes effectsofsarcoma180growthoninterleukin1andcirculatingimmunecomplexes
AT rumil effectsofsarcoma180growthoninterleukin1andcirculatingimmunecomplexes
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