Molecular interaction of BMP-4, TGF-β, and estrogens in lactotrophs: Impact on the PRL promoter

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The regulatory role of estrogen, bone morphogenetic protein-4 (BMP-4), and TGF-β has a strong impact on hormone secretion, gene transcription, and cellular growth of prolactin (PRL)-producing cells. In contrast to TGF-β, BMP-4 induces the secretion of PRL in GH3 cells. Therefore, we studied the mech...

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Detalles Bibliográficos
Autores principales: Giacomini, D., Páez-Pereda, M., Stalla, J., Stalla, G.K., Arzt, E.
Formato: JOUR
Materias:
bone morphogenetic protein 4
estrogen
estrogen receptor
fulvestrant
prolactin
Smad protein
Smad1 protein
transforming growth factor beta
animal cell
article
binding site
chromatin immunoprecipitation
controlled study
estrogen responsive element
gene mutation
hormone release
mutagenesis
nonhuman
priority journal
prolactin secreting cell
protein analysis
protein binding
protein expression
protein function
protein localization
protein protein interaction
rat
Animals
Binding Sites
Bone Morphogenetic Protein 4
Cells, Cultured
Estrogens
Lactotrophs
Prolactin
Promoter Regions, Genetic
Protein Binding
Rats
Receptor Cross-Talk
Receptors, Estrogen
Smad Proteins
Transcriptional Activation
Transforming Growth Factor beta
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_08888809_v23_n7_p1102_Giacomini
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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