Oxidative stress damage circumscribed to the central temporal retinal pigment epithelium in early experimental non-exudative age-related macular degeneration

Non-exudative age-related macular degeneration (NE-AMD) represents the leading cause of blindness in the elderly. The macular retinal pigment epithelium (RPE) lies in a high oxidative environment because its high metabolic demand, mitochondria concentration, reactive oxygen species levels, and macul...

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Autores principales:	Dieguez, H.H., Romeo, H.E., Alaimo, A., González Fleitas, M.F., Aranda, M.L., Rosenstein, R.E., Dorfman, D.
Formato:	JOUR
Materias:	Antioxidant system Mitochondria Non-exudative age-related macular degeneration Oxidative stress Retinal pigment epithelium Superior cervical ganglion catalase copper zinc superoxide dismutase glutathione peroxidase heme oxygenase 1 manganese superoxide dismutase melanin superoxide transcription factor Nrf2 adult age related macular degeneration animal experiment animal model animal tissue antioxidant activity Article C57BL 6 mouse cell nucleus cellular parameters controlled study disorders of mitochondrial functions enzyme activity histopathology lipid peroxidation male mitochondrial mass mouse non exudative age related macular degeneration nonhuman oxidative stress pathophysiology priority journal protein analysis retina pigment epitheliopathy retinal outer nuclear layer retinal pigment epithelium superior cervical ganglionectomy
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_08915849_v131_n_p72_Dieguez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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