Isobutylmethylxanthine and other classical cyclic nucleotide phosphodiesterase inhibitors affect cAMP-dependent protein kinase activity

The effect of 17 inhibitors of cyclic nucleotide phosphodiesterases (PDEs) was assayed on cAMP binding activity of Mucor rouxii protein kinase A (PKA), on PKA activity in the absence of cAMP and on free catalytic subunit (C) activity. Isobutylmethylxanthine (IBMX), SQ 20,009 and cilostamide, at 0.2...

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Detalles Bibliográficos
Autores principales: Tomes, C., Rossi, S., Moreno, S.
Formato: JOUR
Materias:
inhibitors
isobutylmethylxanthine
Phosphodiesterase
protein kinase A
1 ethyl 4 hydrazino 1h pyrazolo[3,4 b]pyridine 5 carboxylic acid ethyl ester
2 amino 4,5 dihydro 6 methyl 5 oxo 4 propyl 1,2,4 triazolo[1,5 a]pyrimidine
4 (3 butoxy 4 methoxybenzyl) 2 imidazolidinone
4,5 dihydro 6 [4 (1h imidazol 1 yl)phenyl] 5 methyl 3(2h) pyridazinone
6 [4 (3 methylureido)phenyl] 3(2h) pyridazinone
amrinone
cilostamide
cilostazol
cyclic amp dependent protein kinase
dipyridamole
etazolate
imazodan
milrinone
papaverine
phosphodiesterase inhibitor
rolipram
sq 65442
theophylline
unclassified drug
article
enzyme inhibition
ligand binding
mucor
mucor rouxii
nonhuman
priority journal
signal transduction
1-Methyl-3-isobutylxanthine
Animal
Cyclic AMP
Cyclic AMP-Dependent Protein Kinases
Etazolate
In Vitro
Mucor
Myocardium
Phosphodiesterase Inhibitors
Quinolones
Rats
Signal Transduction
Support, Non-U.S. Gov't
Amylomyces rouxii
Eukaryota
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_08986568_v5_n5_p615_Tomes
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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