β-Carboline derivatives as novel antivirals for herpes simplex virus

Several commercial and novel synthetic β-carbolines (βCs) were evaluated for their antiviral activity against herpes simplex virus type 1 (HSV-1) using an adapted MTS assay. Of 21 drugs tested, although 11 exerted antiviral activity at non-cytotoxic concentrations, only 3 of them [9-methyl-norharman...

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Detalles Bibliográficos
Autores principales:	Gonzalez, M.M., Cabrerizo, F.M., Baiker, A., Erra-Balsells, R., Osterman, A., Nitschko, H., Vizoso-Pinto, M.G.
Formato:	JOUR
Materias:	Alkaloids Antiherpetic Antiviral Carbolines Herpes simplex virus ICP0 1 ethyl norharmane 6 bromo harmine 6 chloro harmane 6 chloro harmine 6 chloro norharmane 6 methoxy harmane 6,8 dibromo harmane 6,8 dibromo harmine 6,8 dibromo norharmane 6,8 dichloro harmane 6,8 dichloro harmine 8 bromo harmane 8 bromo norharmane 8 chloro harmane 8 chloro norharmane 9 methyl harmane 9 methyl norharmane antivirus agent beta carboline beta carboline derivative harmaline harman harmine unclassified drug animal cell antiviral activity Article assay controlled study cytotoxicity drug absorption drug distribution drug excretion drug metabolism drug selectivity EC50 flow cytometry Herpes simplex virus 2 Human alphaherpesvirus 1 MTS assay nonhuman plaque reduction assay priority journal protein expression time of addition assay virus attachment virus replication Western blotting
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_09248579_v52_n4_p459_Gonzalez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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