The Alzheimer-related gene presenilin-1 facilitates sonic hedgehog expression in Xenopus primary neurogenesis

We analyzed the influence of presenilins on the genetic cascades that control neuronal differentiation in Xenopus embryos. Resembling sonic hedgehog (shh) overexpression, presenilin mRNA injection reduced the number of N-tubulin+ primary neurons and modulated Gli3 and Zic2 according to their roles i...

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Detalles Bibliográficos
Autores principales: Paganelli, A.R., Ocaña, O., Prat, M.I., Franco, P.G., López, S.L., Morelli, L., Adamo, A.M., Riccomagno, M.M., Matsubara, E., Shoji, M., Affranchino, J.L., Castaño, E.M., Carrasco, A.E.
Formato: JOUR
Materias:
Apoptosis
Morpholino oligonucleotide
Presenilin
Primary neurogenesis
Proliferation
Sonic hedgehog
Xenopus laevis
antisense oligonucleotide
messenger RNA
presenilin 1
sonic hedgehog protein
Alzheimer disease
apoptosis
article
controlled study
embryo
gene expression regulation
immunohistochemistry
nervous system development
nonhuman
priority journal
reverse transcription polymerase chain reaction
Xenopus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09254773_v107_n1-2_p119_Paganelli
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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