Proposed molecular model for electrostatic interactions between insulin and chitosan. Nano-complexation and activity in cultured cells

The objective of this contribution was to propose a model that would explain the nanocomplexes formation between Human Recombinant Insulin (I) and a polydisperse Chitosan (CS). Such an objective implied exploring I and CS concentration conditions that allowed the formation of complexes with defined...

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Detalles Bibliográficos
Autores principales: Silva, C.P., Martínez, J.H., Martínez, K.D., Farías, M.E., Leskow, F.C., Pérez, O.E.
Formato: JOUR
Materias:
Chitosan
Insulin
Macromolecular assembly
Nano-complexes
Bioactivity
Cell culture
Chitin
Dynamic light scattering
Electrostatics
Light scattering
Nanostructures
Zeta potential
Absorbance measurements
Complexation process
Controlled release
Different stages
Flow behaviors
Solution dynamics
Surface proteins
biopolymer
chitosan
membrane protein
nanoshell
protein aggregate
recombinant human insulin
3T3-L1 cell line
Article
biological activity
cell culture
colloid
complex formation
concentration (parameters)
controlled release formulation
flow kinetics
kinetic parameters
macromolecule
molecular model
nanotechnology
particle size
pH
photon correlation spectroscopy
priority journal
static electricity
time factor
viscosity
zeta potential
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09277757_v537_n_p425_Silva
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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