Structure-activity relationships of neuroactive steroids acting on the GABAA receptor

The term "neuroactive steroid" (NAS) refers to steroids which, independent of their origin, are capable of modifying neural activities. These steroids positively or negatively modulate the function of members of the ligand-gated ion channel superfamily. Those with positive allosteric actio...

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Detalles Bibliográficos
Autores principales: Veleiro, A.S., Burton, G.
Formato: JOUR
Materias:
Anticonvulsant
GABAA receptor
Neuroactive steroids
Neurosteroids
Structure-activity relationship
17 phenyl 5alpha androst 16 en 3alpha ol
17alpha aza d homosteroid derivative
17beta alkynyl derivative
17beta carbonitrile
2 isopropylmorpholine derivative
22 bromoalkynyl derivative
3alpha amino 5alpha pregan 20 one
3alpha hydroxy 3beta trifluoromethyl 19 nor 5beta pregnan 20 one
3alpha hydroxy 5alpha pregnan 20 one
3alpha,21 dihydroxy 5 alpha pregnan 20 one
3beta carboxamidomethyl
3beta hydroxymethyl
3beta methyl derivative
4 aminobutyric acid receptor
alfaxalone
alkynyl pregnanediol derivative
allotetrahydrodeoxycorticosterone
androsterone
azasteroid derivative
chlorine 36
eltanolone
fluorinated steroid
ganaxolone
minaxolone
oxetane derivative
pregnanediol derivative
steroid
tertiary amine
tetrahydrodeoxycorticosterone
unclassified drug
unindexed drug
4 aminobutyric acid A receptor
anticonvulsant activity
anxiety disorder
binding affinity
binding site
brain electrophysiology
cerebellum
clinical trial
drug receptor binding
drug synthesis
drug targeting
drug withdrawal
epilepsy
human
insomnia
membrane binding
nonhuman
pharmacophore
protein expression
protein targeting
review
structure activity relation
structure analysis
synaptic membrane
synaptosome
urticaria
animal
chemical structure
chemistry
physiology
Animals
Humans
Molecular Structure
Receptors, GABA-A
Steroids
Structure-Activity Relationship
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09298673_v16_n4_p455_Veleiro
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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