Synthesis and NMR Studies of Some Steroidal Isoxazoles
A short synthesis of 17α-pregna-2,4-dien-[2,3-d]isoxazol-17β-ol (1) is described using mild reaction conditions and with a high overall yield. The equilibrium between keto-enolic forms has been studied by 1H NMR methods. Complete assignments o f all the resonances in the 1H and 16C NMR spectra o f D...
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| Autores principales: | , , |
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| Formato: | JOUR |
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_09320776_v47_n6_p891_Giacopello |
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| Sumario: | A short synthesis of 17α-pregna-2,4-dien-[2,3-d]isoxazol-17β-ol (1) is described using mild reaction conditions and with a high overall yield. The equilibrium between keto-enolic forms has been studied by 1H NMR methods. Complete assignments o f all the resonances in the 1H and 16C NMR spectra o f Danazol have been made using a variety o f one and two-dimensional correlation methods. 13C NMR spectra of all the intermediate and related model compounds were also assigned. © 1992, Walter de Gruyter. All rights reserved. |
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