Dehydroepiandrosterone and metformin modulate progesterone-induced blocking factor (PIBF), cyclooxygenase 2 (COX2) and cytokines in early pregnant mice

The present study examined the mechanism by which metformin (N,N′-dimethylbiguanide) prevents embryonic resorption induced in mice by dehydroepiandrosterone (DHEA). Treatment with DHEA (60 mg/kg, s.c. 24 and 48 h post-implantation) induces embryo resorption of early pregnant BALB/c mice while simult...

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Detalles Bibliográficos
Autores principales: Luchetti, C.G., Mikó, E., Szekeres-Bartho, J., Paz, D.A., Motta, A.B.
Formato: JOUR
Materias:
Cytokines
Dehydroepiandrosterone
Metformin
PIBF
Pregnancy
Progesterone
cyclooxygenase 2
cytokine
gamma interferon
interleukin 2
interleukin 4
interleukin 6
metformin
placenta protein
prasterone
progesterone
progesterone induced blocking factor protein
prostaglandin
animal experiment
animal model
animal tissue
article
blocking factor
controlled study
cytokine production
drug mechanism
embryo resorption
enzyme linked immunosorbent assay
female
immunohistochemistry
mouse
nonhuman
protein blood level
protein expression
Animals
Cyclooxygenase 2
Embryo Implantation
Embryo Loss
Embryo, Mammalian
Female
Hypoglycemic Agents
Male
Mice
Mice, Inbred BALB C
Pregnancy Proteins
Pregnancy, Animal
Suppressor Factors, Immunologic
Animalia
Mus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09600760_v111_n3-5_p200_Luchetti
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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