Differential Effects of Environment-Induced Changes in Body Temperature on Modafinil’s Actions Against Methamphetamine-Induced Striatal Toxicity in Mice

Methamphetamine (METH) exposure can produce hyperthermia that might lead to toxicity and death. Modafinil is a wake-promoting compound that is also been prescribed off-label to treat METH dependence. Modafinil has shown neuroprotective properties against METH harmful effects in animal models. The go...

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Autores principales:	Raineri, M., González, B., Rivero-Echeto, C., Muñiz, J.A., Gutiérrez, M.L., Ghanem, C.I., Cadet, J.L., García-Rill, E., Urbano, F.J., Bisagno, V.
Formato:	JOUR
Materias:	Astroglia Dopamine Methamphetamine Modafinil Striatum Toxicity dopamine transporter glial fibrillary acidic protein methamphetamine modafinil placebo protein c fos tyrosine 3 monooxygenase benzhydryl derivative dopamine receptor stimulating agent neuroprotective agent animal cell animal experiment animal model animal tissue Article body temperature disorder body temperature measurement cell nucleus cellular distribution controlled study corpus striatum correlational study disease marker down regulation drug protein binding drug targeting environmental exposure environmental temperature female hyperthermia immunohistochemistry immunoreactivity mouse mouse model neuropharmacology neuroprotection neurotoxicity nonhuman priority journal protein determination protein expression protein localization thermal exposure thermoregulation tissue distribution upregulation animal C57BL mouse chemically induced cold cytology drug effects heat hypothermia metabolism neostriatum nerve cell Animals Benzhydryl Compounds Cold Temperature Dopamine Agents Dopamine Plasma Membrane Transport Proteins Female Hot Temperature Hypothermia Mice Mice, Inbred C57BL Neostriatum Neurons Neuroprotective Agents Proto-Oncogene Proteins c-fos Tyrosine 3-Monooxygenase
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_10298428_v27_n1_p71_Raineri
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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