Prostate tumor growth is impaired by CtBP1 depletion in high-fat diet-fed mice

Purpose: Clinical and epidemiologic data suggest that obesity is associated with more aggressive forms of prostate cancer, poor prognosis, and increased mortality. C-terminal-binding protein 1 (CtBP1) is a transcription repressor of tumor suppressor genes and is activated by NADH binding. High calor...

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Detalles Bibliográficos
Autores principales: Moiola, C.P., Luca, P.D., Zalazar, F., Cotignola, J., Rodríguez-Seguí, S.A., Gardner, K., Meiss, R., Vallecorsa, P., Pignataro, O., Mazza, O., Vazquez, E.S., De Siervi, A.
Formato: JOUR
Materias:
carboxy terminal binding protein 1
tumor suppressor protein
unclassified drug
alcohol dehydrogenase
C-terminal binding protein
DNA binding protein
messenger RNA
sex hormone
small interfering RNA
tumor marker
animal cell
animal experiment
animal model
animal tissue
article
cancer inhibition
cell adhesion
cell cycle
controlled study
gene expression
gene identification
genetic analysis
in vitro study
in vivo study
lipid diet
male
metabolism
mouse
nonhuman
priority journal
prostate cancer
protein depletion
protein function
adverse effects
animal
antagonists and inhibitors
apoptosis
cell proliferation
cell transformation
chromatin immunoprecipitation
DNA microarray
drug effects
drug screening
enzyme immunoassay
gene expression profiling
genetics
human
metabolic syndrome X
nude mouse
obesity
pathology
Prostatic Neoplasms
real time polymerase chain reaction
reverse transcription polymerase chain reaction
tumor cell culture
Western blotting
Alcohol Oxidoreductases
Animals
Apoptosis
Blotting, Western
Cell Adhesion
Cell Proliferation
Cell Transformation, Neoplastic
Chromatin Immunoprecipitation
Diet, High-Fat
DNA-Binding Proteins
Gene Expression Profiling
Gonadal Steroid Hormones
Humans
Immunoenzyme Techniques
Male
Metabolic Syndrome X
Mice
Mice, Nude
Obesity
Oligonucleotide Array Sequence Analysis
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger
RNA, Small Interfering
Tumor Cells, Cultured
Tumor Markers, Biological
Xenograft Model Antitumor Assays
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_10780432_v20_n15_p4086_Moiola
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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