Expression profile of shelterin components in plasma cell disorders. Clinical significance of POT1 overexpression

The core complex of telomere-associated proteins, named the shelterin complex, plays a critical role in telomere protection and telomere length (TL) homeostasis. In this study, we have explored changes in the expression of telomere-associated genes POT1, TIN2, RAP1 and TPP1, in patients with monoclo...

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Detalles Bibliográficos
Autores principales: Panero, J., Stanganelli, C., Arbelbide, J., Fantl, D.B., Kohan, D., García Rivello, H., Rabinovich, G.A., Slavutsky, I.
Formato: JOUR
Materias:
MGUS
Multiple myeloma
POT1 expression
Telomere associated genes
beta 2 microglobulin
calcium
pot1 protein
protein
Rap1 protein
shelterin
TIN2 protein
TPP1 protein
unclassified drug
article
clinical feature
gene
gene expression
gene expression profiling
hemostasis
human
major clinical study
monoclonal immunoglobulinemia
multiple myeloma
overall survival
plasma cell
plasma cell leukemia
POT1 gene
priority journal
prognosis
protein expression
RAP1 gene
real time polymerase chain reaction
restriction fragment
telomere
TIN2 gene
TPP1 gene
Aged
Aged, 80 and over
DNA Methylation
Follow-Up Studies
Galectin 1
Gene Expression Profiling
Humans
Middle Aged
Monoclonal Gammopathy of Undetermined Significance
Multiple Myeloma
Prognosis
Promoter Regions, Genetic
Telomerase
Telomere-Binding Proteins
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_10799796_v52_n2-3_p134_Panero
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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