Different signaling pathways are involved in cardiomyocyte survival induced by a Trypanosoma cruzi glycoprotein

We have recently reported that Trypanosoma cruzi infection protects cardiomyocytes against apoptosis induced by growth factor deprivation. Cruzipain, a major parasite antigen, reproduced this survival effect by a Bcl-2-dependent mechanism. In this study, we have investigated the molecular mechanisms...

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Detalles Bibliográficos
Autores principales: Aoki, M.d.P., Cano, R.C., Pellegrini, A.V., Tanos, T., Guiñazú, N.L., Coso, O.A., Gea, S.
Formato: JOUR
Materias:
Cardiomyocyte
MAPKs
PI3K/Akt
Trypanosoma cruzi
2 (2 amino 3 methoxyphenyl)chromone
2 morpholino 8 phenylchromone
4 (4 fluorophenyl) 2 (4 methylsulfinylphenyl) 5 (4 pyridyl)imidazole
anthra[1,9 cd]pyrazol 6(2h) one
cruzipain
glycoprotein
mitogen activated protein kinase
mitogen activated protein kinase p38
phosphatidylinositol 3 kinase
protein BAD
protein bcl 2
protein bcl xl
protein kinase B
protozoal protein
stress activated protein kinase
animal cell
animal model
apoptosis
article
cell protection
cell survival
controlled study
enzyme inhibition
enzyme phosphorylation
heart cell culture
heart muscle cell
molecular mechanics
mouse
newborn
nonhuman
premedication
priority journal
protein expression
protozoal infection
signal transduction
1-Phosphatidylinositol 3-Kinase
Animals
Apoptosis
bcl-Associated Death Protein
bcl-X Protein
Caspase 3
Caspases
Cell Survival
Cells, Cultured
Chromones
Cysteine Endopeptidases
Enzyme Inhibitors
Flavonoids
Gene Expression
Genes, bcl-2
Humans
Imidazoles
JNK Mitogen-Activated Protein Kinases
MAP Kinase Kinase 1
Mice
Morpholines
Myocytes, Cardiac
p38 Mitogen-Activated Protein Kinases
Phosphorylation
Pyridines
Signal Transduction
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_12864579_v8_n7_p1723_Aoki
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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