A whole genome bioinformatic approach to determine potential latent phase specific targets in Mycobacterium tuberculosis

Summary Current Tuberculosis treatment is long and expensive, faces the increasing burden of MDR/XDR strains and lack of effective treatment against latent form, resulting in an urgent need of new anti-TB drugs. Key to TB biology is its capacity to fight the host's RNOS mediated attack. RNOS ar...

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Detalles Bibliográficos
Autores principales: Defelipe, L.A., Do Porto, D.F., Pereira Ramos, P.I., Nicolás, M.F., Sosa, E., Radusky, L., Lanzarotti, E., Turjanski, A.G., Marti, M.A.
Formato: JOUR
Materias:
Latent phase
Mycobacterium tuberculosis
Reactive oxygen and nitrogen species (RNOS)
Structural bioinformatics
proteome
bacterial protein
reactive nitrogen species
reactive oxygen metabolite
tuberculostatic agent
amino acid sequence
Article
bacterial metabolism
bactericidal activity
bioinformatics
controlled study
genome
infection
meta analysis (topic)
microarray analysis
nonhuman
oxidative stress
priority journal
sensitivity analysis
stress
structural homology
animal
bacterial genome
biology
C57BL mouse
DNA microarray
drug development
drug effects
gene expression profiling
genetic database
genetics
genome-wide association study
host pathogen interaction
human
latent tuberculosis
meta analysis
metabolism
microbial viability
microbiology
molecularly targeted therapy
pathogenicity
procedures
protein protein interaction
signal transduction
Animals
Antitubercular Agents
Bacterial Proteins
Computational Biology
Databases, Genetic
Drug Discovery
Gene Expression Profiling
Genome, Bacterial
Genome-Wide Association Study
Host-Pathogen Interactions
Humans
Latent Tuberculosis
Mice, Inbred C57BL
Microbial Viability
Molecular Targeted Therapy
Oligonucleotide Array Sequence Analysis
Protein Interaction Maps
Reactive Nitrogen Species
Reactive Oxygen Species
Signal Transduction
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_14729792_v97_n_p181_Defelipe
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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