pH-dependent mechanism of nitric oxide release in nitrophorins 2 and 4

Nitrophorins are NO carrier proteins that transport and release NO through a pH-dependent conformational change. They bind NO tightly in a low pH environment and release it in a higher pH environment. Experimental evidence shows that the increase in the NO dissociation equilibrium constant, K d, is...

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Detalles Bibliográficos
Autores principales: Swails, J.M., Meng, Y., Walker, F.A., Marti, M.A., Estrin, D.A., Roitberg, A.E.
Formato: JOUR
Materias:
Dynamics
Equilibrium constants
Molecular dynamics
Nitric oxide
Porphyrins
Active sites
Carrier proteins
Conformational changes
Escape process
Escape rates
Escape routes
Experimental evidences
Heme proteins
High pH
Kinetic datum
Molecular dynamics simulations
Nitric oxide release
No dissociations
No release
pH dependents
Release mechanisms
Sequence identities
State-of-the arts
Structural basis
Structural transitions
Proteins
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_15206106_v113_n4_p1192_Swails
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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