Signaling processes in tumoral neuroendocrine pituitary cells as potential targets for therapeutic drugs

Pituitary adenomas are neuroendocrine tumors that produce different endocrine and metabolic alterations, including hyperprolactinemia, acromegaly and Cushing's disease. These different clinical features of pituitary tumors are the result of the overproduction of hormones produced by the differe...

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Detalles Bibliográficos
Autores principales:	Paez-Pereda, M., Giacomini, D., Echenique, C., Stalla, G.K., Holsboer, F., Arzt, E.
Formato:	JOUR
Materias:	1 [n,o bis(5 isoquinolinesulfonyl) n methyltyrosyl] 4 phenylpiperazine 1,4 diamino 1,4 bis(2 aminophenylthio) 2,3 dicyanobutadiene 2 (2 amino 3 methoxyphenyl)chromone angiopeptin bone morphogenetic protein cell nucleus receptor corticotropin cyclic AMP dependent protein kinase cytokine estradiol estrogen derivative estrogen receptor glycoprotein gp 130 growth hormone hypophysis hormone mitogen activated protein kinase n (2 phenylcyclopentyl)azacyclotridecan 2 imine n [2 (4 bromocinnamylamino)ethyl] 5 isoquinolinesulfonamide nuclear receptor related factor 1 octreotide peroxisome proliferator activated receptor gamma prolactin protein kinase (calcium,calmodulin) protein kinase C retinoic acid receptor retinol rosiglitazone Smad protein transforming growth factor beta unindexed drug acromegaly cancer inhibition cell proliferation cell type clinical feature Cushing syndrome drug targeting endocrine disease enzyme activation enzyme inhibition hormonal regulation hormone inhibition hormone synthesis human hyperprolactinemia hypophysis adenoma hypophysis cell metabolic disorder neuroendocrine tumor nonhuman prolactin synthesis prolactinoma protein family protein protein interaction review secretory cell signal transduction transcription regulation Adrenocorticotropic Hormone Animals Cytokines Drug Delivery Systems Gene Expression Regulation Humans Neurosecretory Systems Pituitary Neoplasms Prolactin Receptors, Cytokine Signal Transduction Transforming Growth Factor beta
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_15680088_v5_n3_p259_PaezPereda
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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