Experimental and clinical evidence for the protective role of progesterone in motoneuron degeneration and neuroinflammation

Far beyond its role in reproduction., progesterone exerts neuroprotective., promyelinating, and anti-inflammatory effects in the nervous system. These effects are amplified under pathological conditions., implying that changes of the local environment sensitize nervous tissues to steroid therapy. Th...

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Detalles Bibliográficos
Autores principales: Deniselle, M.C.G., Garay, L., Meyer, M., Gargiulo-Monachelli, G., Labombarda, F., Gonzalez, S., De Nicola, A., Guennoun, R., Schumacher, M., De Nicola, F.
Formato: JOUR
Materias:
experimental autoimmune encephalomyelitis
motoneuron degeneration
neuroinflammation
neuroprotection
progesterone
Wobbler mouse
amyloid precursor protein
cell nucleus receptor
growth associated protein
membrane receptor
neurotrophin
sex hormone
amyotrophic lateral sclerosis
axon
clinical trial (topic)
demyelination
disease severity
drug effect
enzyme metabolism
evidence based practice
human
long term care
motoneuron
motor neuron disease
multicenter study (topic)
multiple sclerosis
muscle strength
nerve cell degeneration
nervous system inflammation
neurotransmission
nonhuman
priority journal
protein expression
relapse
Review
survival rate
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_18681883_v7_n3_p403_Deniselle
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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