Synthesis and cytotoxicity evaluation of A-ring derivatives of cycloartanone

Sixteen derivatives, eight of which are new compounds, were prepared from cycloartenone (1) and cycloartanone (2), and the cytotoxic activity of 14 of these compounds, together with 1 and 2, was evaluated against a panel of four cell lines. Compound 1 was obtained from the epiphyte plant Tillandsia...

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Detalles Bibliográficos
Autores principales: Zambrano, E.E., Casas, A.G., Di Venosa, G.M., Uriburu, M.L., Duran, F.J., Palermo, J.A.
Formato: JOUR
Materias:
Cycloartanes
Cycloartanone
Cytotoxicity
Synthetic derivatives
Tillandsia tenuifolia
2 amino cycloart 1 en 3 one
2 chloro cycloart 1 en 3 one
2 hydroxy cycloart 1 en 3 one
2,2 dibromo cycloartan 3 one
2,2 dichloro cycloartan 3 one
2alpha azido cycloartan 3 one
2alpha chloro cycloartan 3 one
2alpha fluor cycloartan 3 one
2beta fluor cycloartan 3 one
3 benzoyl cycloart 2 ene
antineoplastic agent
cycloartane derivative
cycloartenone derivative
diosphenol
doxorubicin
triterpene derivative
unclassified drug
animal cell
Article
carbon nuclear magnetic resonance
chemical phenomena
chemoselectivity
chlorination
controlled study
cytotoxicity
cytotoxicity assay
drug isolation
drug synthesis
heteronuclear multiple bond correlation
high performance liquid chromatography
human
human cell
hydrogenation
IC50
keratinocyte cell line
MCF-7 cell line
nonhuman
nuclear Overhauser effect
priority journal
proton nuclear magnetic resonance
regioselectivity
structure activity relation
thin layer chromatography
Tillandsia
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_18743900_v21_n_p200_Zambrano
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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