Acute modulation of calcium currents and synaptic transmission by gabapentinoids

Gabapentin and pregabalin are anticonvulsant drugs that are extensively used for the treatment of several neurological and psychiatric disorders. Gabapentinoids (GBPs) are known to have a high affinity binding to α2δ-1 and α2δ-2 auxiliary subunit of specific voltage-gated calcium channels. Despite t...

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Detalles Bibliográficos
Autores principales:	Uchitel, O.D., Di Guilmi, M.N., Urbano, F.J., Inchauspe, C.G.
Formato:	JOUR
Materias:	Calcium channels Calyx of held Gabapentin Mice Neuromuscular junction Pregabalin Synaptic transmission 4 aminobutyric acid amino acid transporter calcium channel P type calcium channel Q type gabapentin glycine n methyl dextro aspartic acid neurotransmitter potassium channel pregabalin sodium channel thrombospondin voltage gated calcium channel amine anticonvulsive agent calcium channel cyclohexanecarboxylic acid derivative drug derivative ligand binding affinity calcium current central nervous system dose response drug protein binding drug targeting electrophysiology human ligand binding modulation neurochemistry neuromuscular synapse neurotransmitter release nonhuman protein interaction review skeletal muscle spinal ganglion synaptic transmission animal binding competition binding site brain calcium signaling drug effect kinetics metabolism synapse synaptic potential synaptosome Mus Amines Animals Anticonvulsants Binding Sites Binding, Competitive Brain Calcium Channels Calcium Signaling Cyclohexanecarboxylic Acids Dose-Response Relationship, Drug gamma-Aminobutyric Acid Humans Kinetics Ligands Presynaptic Terminals Synapses Synaptic Potentials Synaptic Transmission
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_19336950_v4_n6_p_Uchitel
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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