RUNX1 and FOXP3 interplay regulates expression of breast cancer related genes

Runx1 participation in epithelial mammary cells is still under review. Emerging data indicates that Runx1 could be relevant for breast tumor promotion. However, to date no studies have specifically evaluated the functional contribution of Runx1 to control gene expression in mammary epithelial tumor...

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Detalles Bibliográficos
Autores principales:	Recouvreux, M.S., Grasso, E.N., Echeverria, P.C., Rocha-Viegas, L., Castilla, L.H., Schere-Levy, C., Tocci, J.M., Kordon, E.C., Rubinstein, N.
Formato:	JOUR
Materias:	Foxp3 Gene expression regulation GJA1 Rspo3 Runx1 transcription factor FOXP3 transcription factor RUNX1 connexin 43 forkhead transcription factor FOXP3 protein, human GJA1 protein, human RSPO3 protein, human RUNX1 protein, human thrombospondin animal cell Article breast cancer breast cell breast epithelium cell cell migration controlled study down regulation FOXP3 gene gene activity gene expression gene interaction genetic transcription GJA1 gene in vitro study nonhuman pathogenesis promoter region RUNX1 gene tumor suppressor gene upregulation adenocarcinoma animal apoptosis Bagg albino mouse breast tumor cell motion cell proliferation chromatin immunoprecipitation confocal microscopy drug screening enzyme immunoassay female fluorescence microscopy fluorescent antibody technique gene expression regulation genetics human immunoprecipitation metabolism mouse pathology tumor cell culture Western blotting wound healing Adenocarcinoma Animals Apoptosis Blotting, Western Breast Neoplasms Cell Movement Cell Proliferation Chromatin Immunoprecipitation Connexin 43 Core Binding Factor Alpha 2 Subunit Female Fluorescent Antibody Technique Forkhead Transcription Factors Gene Expression Regulation, Neoplastic Humans Immunoenzyme Techniques Immunoprecipitation Mice Mice, Inbred BALB C Microscopy, Confocal Microscopy, Fluorescence Promoter Regions, Genetic Thrombospondins Tumor Cells, Cultured Wound Healing Xenograft Model Antitumor Assays
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_19492553_v7_n6_p6552_Recouvreux
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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