Proteomic and functional analysis identifies galectin-1 as a novel regulatory component of the cytotoxic granule machinery

Secretory granules released by cytotoxic T lymphocytes (CTLs) are powerful weapons against intracellular microbes and tumor cells. Despite significant progress, there is still limited information on the molecular mechanisms implicated in target-driven degranulation, effector cell survival and compos...

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Detalles Bibliográficos
Autores principales:	Clemente, T., Vieira, N.J., Cerliani, J.P., Adrain, C., Luthi, A., Dominguez, M.R., Yon, M., Barrence, F.C., Riul, T.B., Cummings, R.D., Zorn, T.M., Amigorena, S., Dias-Baruffi, M., Rodrigues, M.M., Martin, S.J., Rabinovich, G.A., Amarante-Mendes, G.P.
Formato:	JOUR
Materias:	Fas ligand Fas protein, mouse Fasl protein, mouse galectin 1 tumor necrosis factor receptor superfamily member 6 animal C57BL mouse cell proliferation chemistry cytology cytotoxic T lymphocyte cytotoxicity degranulation gene expression profiling gene expression regulation genetics immunology knockout mouse lymphocyte activation male metabolism mouse proteomics secretory vesicle signal transduction Animals Cell Degranulation Cell Proliferation Cytotoxicity, Immunologic Fas Ligand Protein fas Receptor Galectin 1 Gene Expression Profiling Gene Expression Regulation Lymphocyte Activation Male Mice Mice, Inbred C57BL Mice, Knockout Proteomics Secretory Vesicles Signal Transduction T-Lymphocytes, Cytotoxic
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_20414889_v8_n12_pe3176_Clemente
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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