Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via TLR9 and MyD88 Signaling

Cytomegalovirus (CMV) is an opportunistic virus severely infecting immunocompromised individuals. In mice, endosomal Toll-like receptor 9 (TLR9) and downstream myeloid differentiation factor 88 (MyD88) are central to activating innate immune responses against mouse CMV (MCMV). In this respect, the c...

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Autores principales:	Puttur, F., Francozo, M., Solmaz, G., Bueno, C., Lindenberg, M., Gohmert, M., Swallow, M., Tufa, D., Jacobs, R., Lienenklaus, S., Kühl, A.A., Borkner, L., Cicin-Sain, L., Holzmann, B., Wagner, H., Berod, L., Sparwasser, T.
Formato:	JOUR
Materias:	conventional DC MCMV NK cells plasmacytoid DC TLR9-MyD88 signaling CD69 antigen gamma interferon glycoprotein p 15095 interleukin 15 myeloid differentiation factor 88 toll like receptor 9 antivirus agent animal cell animal experiment animal model antigen expression Article CD11c+ dendritic cell cell activity cell compartmentalization cell specificity controlled study cytokine production cytomegalovirus infection degranulation dendritic cell effector cell immunoregulation infection prevention innate immunity lymphocyte function mouse natural killer cell nonhuman plasmacytoid dendritic cell priority journal protein function signal transduction transgenic mouse viral clearance animal Bagg albino mouse cytotoxicity immunology lymphocyte activation metabolism Muromegalovirus physiology virology Animals Antiviral Agents CD11c Antigen Cytomegalovirus Infections Cytotoxicity, Immunologic Dendritic Cells Interferon-gamma Killer Cells, Natural Lymphocyte Activation Mice, Inbred BALB C Myeloid Differentiation Factor 88 Signal Transduction Toll-Like Receptor 9
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_22111247_v17_n4_p1113_Puttur
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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