Antiviral Action of Synthetic Stigmasterol Derivatives on Herpes Simplex Virus Replication in Nervous Cells in Vitro

Polyfunctionalized stigmasterol derivatives, (22S,23S)-22,23-dihydroxystigmast-4-en-3-one (compound 1) and (22S,23S)-3β-bromo-5,22,23-trihydroxystigmastan-6-one (compound 2), inhibit herpes simplex virus type 1 (HSV-1) replication and spreading in human epithelial cells derived from ocular tissues....

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Detalles Bibliográficos
Autores principales: Petrera, E., Níttolo, A.G., Alché, L.E.
Formato: JOUR
Materias:
22,23 dihydroxystigmast 4 en 3 one
3beta bromo 5alpha,22,23 trihydroxystigmastan 6 one
gamma interferon
interleukin 6
stigmasterol
unclassified drug
22,23-dihydroxystigmast-4-en-3-one
3-bromo-5,22,23-trihydroxystigmastan-6-one
antiinflammatory agent
antivirus agent
cholestane derivative
animal cell
antiinflammatory activity
antiviral activity
Article
controlled study
cytokine production
cytotoxicity assay
herpes simplex keratitis
Herpes simplex virus 1
human
human cell
immunopathology
interferon production
nerve cell
nonhuman
virus inhibition
virus replication
analogs and derivatives
animal
cell line
Chlorocebus aethiops
drug effects
epithelium cell
inflammation
metabolism
mouse
Vero cell line
Human herpesvirus 1
Murinae
Simplexvirus
Animals
Anti-Inflammatory Agents
Antiviral Agents
Cell Line
Cercopithecus aethiops
Cholestanones
Epithelial Cells
Herpesvirus 1, Human
Humans
Inflammation
Interferon-gamma
Interleukin-6
Mice
Stigmasterol
Vero Cells
Virus Replication
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_23146133_v2014_n_p_Petrera
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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