Simulación numérica del crecimiento de un tumor avascular
A numerical simulation of the growth of a multicellular spheroid was made. First, we took into account the model of Sherratt & Chaplain formulated in terms of cellular densities. Afterwards, we incorporated to the model the contributions of Tan & Ang, who added a random term to the nutrient...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_97814673_v_n_p_Weiman |
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todo:paper_97814673_v_n_p_Weiman2023-10-03T16:43:34Z Simulación numérica del crecimiento de un tumor avascular Weiman, M. Vignetta, E. Maiza, I.Z. A numerical simulation of the growth of a multicellular spheroid was made. First, we took into account the model of Sherratt & Chaplain formulated in terms of cellular densities. Afterwards, we incorporated to the model the contributions of Tan & Ang, who added a random term to the nutrient concentration and a delay factor to the main equations of the model due to the release of cytostatic and cytotoxic factors from the necrotic core of the tumor. Lastly, we proposed a new delay model that led to a more suitable representation of the physiopathological phenomena in so far as the simulation shows the deceleration in the tumor growth and the decrease of proliferative cell density over time, as a consequence of the presence of the aforementioned cytostatic and cytotoxic factors. © 2016 IEEE. CONF info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_97814673_v_n_p_Weiman |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| description |
A numerical simulation of the growth of a multicellular spheroid was made. First, we took into account the model of Sherratt & Chaplain formulated in terms of cellular densities. Afterwards, we incorporated to the model the contributions of Tan & Ang, who added a random term to the nutrient concentration and a delay factor to the main equations of the model due to the release of cytostatic and cytotoxic factors from the necrotic core of the tumor. Lastly, we proposed a new delay model that led to a more suitable representation of the physiopathological phenomena in so far as the simulation shows the deceleration in the tumor growth and the decrease of proliferative cell density over time, as a consequence of the presence of the aforementioned cytostatic and cytotoxic factors. © 2016 IEEE. |
| format |
CONF |
| author |
Weiman, M. Vignetta, E. Maiza, I.Z. |
| spellingShingle |
Weiman, M. Vignetta, E. Maiza, I.Z. Simulación numérica del crecimiento de un tumor avascular |
| author_facet |
Weiman, M. Vignetta, E. Maiza, I.Z. |
| author_sort |
Weiman, M. |
| title |
Simulación numérica del crecimiento de un tumor avascular |
| title_short |
Simulación numérica del crecimiento de un tumor avascular |
| title_full |
Simulación numérica del crecimiento de un tumor avascular |
| title_fullStr |
Simulación numérica del crecimiento de un tumor avascular |
| title_full_unstemmed |
Simulación numérica del crecimiento de un tumor avascular |
| title_sort |
simulación numérica del crecimiento de un tumor avascular |
| url |
http://hdl.handle.net/20.500.12110/paper_97814673_v_n_p_Weiman |
| work_keys_str_mv |
AT weimanm simulacionnumericadelcrecimientodeuntumoravascular AT vignettae simulacionnumericadelcrecimientodeuntumoravascular AT maizaiz simulacionnumericadelcrecimientodeuntumoravascular |
| _version_ |
1807317863857389568 |