5 aminolevulinate synthase article 130 5-Aminolevulinate Synthetase 114 nonhuman 108 Liver 74 animal experiment 70 priority journal 68 controlled study 66 Heme 60 Support, Non-U.S. Gov't 60 heme 58 porphyrin 54 Animals 50 Porphyrins 50 metabolism 50 Animal 48 male 48 mouse 48 Male 46 animal model 46 enzyme activity 46 Mice 44 animal tissue 44 rat 44 liver 42 Rats 38 biosynthesis 36 Animalia 32 heme oxygenase 30 porphobilinogen synthase 30