Hydrophobic and Hydrophilic Interactions chemical phenomena 28 chemistry 26 article 22 Molecular dynamics 18 hydrophobicity 16 Ligands 14 molecular dynamics 14 water 14 Animals 12 Protein Binding 12 Water 12 metabolism 12 priority journal 12 Hydrophobicity 10 Molecular Dynamics Simulation 10 Molecular dynamics simulations 10 Thermodynamics 10 ligand 10 unclassified drug 10 Adsorption 8 Hydrogen-Ion Concentration 8 Protein Structure, Secondary 8 nonhuman 8 Article 6 Bacteria 6 Humans 6 Kinetics 6 Oxygen 6 amino acid sequence 6