Pyrimidines article 16 pyrimidine derivative 12 unclassified drug 10 Humans 8 human 8 Cell Line, Tumor 6 Cell Proliferation 6 cell proliferation 6 controlled study 6 drug effect 6 human cell 6 nonhuman 6 priority journal 6 Animals 4 Antineoplastic Agents 4 Breast Neoplasms 4 Dose-Response Relationship, Drug 4 Drug Screening Assays, Antitumor 4 Enzyme Activation 4 Mutation 4 Phosphorylation 4 Signal Transduction 4 Structure-Activity Relationship 4 animal 4 breast cancer 4 enzyme activation 4 enzyme activity 4 enzyme inhibition 4 enzymology 4