down regulation controlled study 204 nonhuman 176 priority journal 170 article 146 Animals 142 protein expression 124 human 112 metabolism 104 mouse 104 Humans 98 animal cell 92 female 90 animal experiment 88 unclassified drug 86 Female 84 Article 82 Mice 80 animal 80 signal transduction 76 upregulation 76 animal tissue 72 genetics 70 human cell 68 messenger RNA 66 Down-Regulation 56 gene expression regulation 56 apoptosis 54 gene expression 54 protein function 54