heme synthesis article 52 nonhuman 44 controlled study 36 priority journal 34 animal experiment 32 male 32 5-Aminolevulinate Synthetase 30 animal tissue 30 mouse 30 5 aminolevulinate synthase 28 Heme 28 Mice 28 enzyme activity 28 Liver 22 Male 22 Support, Non-U.S. Gov't 22 porphyrin 22 Animals 20 animal model 20 porphobilinogen deaminase 20 human 18 Animal 16 Porphyrins 16 heme 16 porphobilinogen synthase 16 Animalia 14 intraperitoneal drug administration 14 isoflurane 14 Ammonia-Lyases 12