lethality nonhuman 30 article 24 controlled study 20 Animals 18 unclassified drug 18 priority journal 14 animal experiment 12 male 12 female 10 neurotoxicity 10 Drosophila melanogaster 8 Male 8 Mice 8 animal 8 animal model 8 gene mutation 8 human 8 mouse 8 null allele 8 mortality 7 Article 6 Cell Hypoxia 6 Female 6 Hypoxia-Inducible Factor 1, alpha Subunit 6 Immunoglobulin G 6 Oxygen 6 Sima 6 animal tissue 6 bioassay 6