article 84 porphobilinogen deaminase 78 nonhuman 66 male 50 enzyme activity 48 Hydroxymethylbilane Synthase 46 controlled study 44 Support, Non-U.S. Gov't 40 animal tissue 40 animal experiment 36 Liver 34 mouse 34 priority journal 34 Animal 30 Male 28 Mice 28 heme synthesis 26 liver 26 metabolism 26 5 aminolevulinate synthase 24 enzymology 24 Ammonia-Lyases 22 animal model 22 heme 22 porphobilinogen synthase 22 Animals 20 isoflurane 20 rat 20 Kinetics 18 acute intermittent porphyria 18