Common themes in RNA subcellular transport, stress granule formation and abnormal protein aggregation

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Control of protein synthesis and quality are critical steps to support eukaryotic cells' maintenance and survival. Two very distinctive mechanisms emerge as key checkpoints of protein synthesis regulation. The first one is the delivery of mRNA molecules, packed into ribonucleoprotein (mRNP) gra...

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Autor principal: Benseñor, L.B
Otros Autores: Vazquez, M.S, Boccaccio, G.L
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: Bentham Science Publishers B.V. 2011
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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100 1 |a Benseñor, L.B. 
245 1 0 |a Common themes in RNA subcellular transport, stress granule formation and abnormal protein aggregation 
260 |b Bentham Science Publishers B.V.  |c 2011 
270 1 0 |m Boccaccio, G. L.; Instituto Leloir, Avenida Patricias Argentinas 435, C1405BWE-Buenos Aires, Argentina; email: gboccaccio@leloir.org.ar 
506 |2 openaire  |e Política editorial 
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520 3 |a Control of protein synthesis and quality are critical steps to support eukaryotic cells' maintenance and survival. Two very distinctive mechanisms emerge as key checkpoints of protein synthesis regulation. The first one is the delivery of mRNA molecules, packed into ribonucleoprotein (mRNP) granules, to specific subcellular regions in order to restrict protein synthesis to distinct cytoplasmic domains. In the presence of cellular stress or injury, translation is aborted by sequestering mRNA molecules into a sub-type of RNP particles called stress granules (SGs). The second mechanism deals with the folding state and further processing of synthesized proteins. Misbehavior of a particular protein, affecting its processing, functioning, and/or conformation can cause the formation of protein inclusions called aggresomes. Interestingly, self-aggregation of abnormal proteins is one of the leading causes of neurodegenerative disorders. Recently, intracellular transport directed by microtubule-motors, has emerged as an important step in the assembly and dynamic of SGs and aggresomes. This mechanism allows for a precise temporal and spatial trafficking of RNA and protein complexes. Furthermore, it facilitates the regulation of the RNA silencing domains and targets abnormal protein aggregates for degradation. In this review we will explore the specific and common features of mRNA transport and of SG and aggresome formation, and will provide details on the role of the microtubule network and motors in their movement and dynamics. © 2011 Bentham Science Publishers Ltd.  |l eng 
593 |a Instituto Leloir, Avenida Patricias Argentinas 435, C1405BWE-Buenos Aires, Argentina 
593 |a IIBBA CONICET, Facultad de Ciencias Exactas y Naturales, University of Buenos Aires, Argentina 
593 |a IIBBA-CONICET, C1405BWE-Buenos Aires, Argentina 
690 1 0 |a ABNORMAL PROTEIN AGGREGATES 
690 1 0 |a AGGRESOME 
690 1 0 |a CELL STRESS 
690 1 0 |a CYTOSKELETON 
690 1 0 |a DYNEIN 
690 1 0 |a KINESIN 
690 1 0 |a RNP 
690 1 0 |a STRESS GRANULES 
690 1 0 |a RIBONUCLEOPROTEIN 
690 1 0 |a AGGRESOME 
690 1 0 |a CELL DAMAGE 
690 1 0 |a CELL STRESS 
690 1 0 |a CELL SURVIVAL 
690 1 0 |a DEGENERATIVE DISEASE 
690 1 0 |a EUKARYOTIC CELL 
690 1 0 |a GENE SILENCING 
690 1 0 |a HUMAN 
690 1 0 |a MICROTUBULE 
690 1 0 |a NONHUMAN 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a PROTEIN AGGREGATION 
690 1 0 |a PROTEIN CONFORMATION 
690 1 0 |a PROTEIN FOLDING 
690 1 0 |a PROTEIN SYNTHESIS 
690 1 0 |a REVIEW 
690 1 0 |a RNA TRANSLATION 
690 1 0 |a RNA TRANSPORT 
690 1 0 |a STRESS GRANULE 
690 1 0 |a EUKARYOTA 
700 1 |a Vazquez, M.S. 
700 1 |a Boccaccio, G.L. 
773 0 |d Bentham Science Publishers B.V., 2011  |g v. 5  |h pp. 77-89  |k n. 2  |p Curr. Chem. Biol.  |x 18723136  |t Current Chemical Biology 
856 4 1 |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-79953834159&doi=10.2174%2f187231311795243373&partnerID=40&md5=dc784b22664735920419fdb03e3f33ad  |y Registro en Scopus 
856 4 0 |u https://doi.org/10.2174/187231311795243373  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_18723136_v5_n2_p77_Bensenor  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18723136_v5_n2_p77_Bensenor  |y Registro en la Biblioteca Digital 
961 |a paper_18723136_v5_n2_p77_Bensenor  |b paper  |c PE 
962 |a info:eu-repo/semantics/article  |a info:ar-repo/semantics/artículo  |b info:eu-repo/semantics/publishedVersion 
999 |c 71576 

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