Effect of a second injection of human chorionic gonadotropin on the desensitized Leydig cells
Experimental evidence has demonstrated that multiple doses of LH will increase the steroidogenic capacity of Leydig cells. This work was undertaken with the aim of defining the effect of a second hCG administration on the desensitized state, measuring binding of the gonadotropin and the steroidogeni...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1984
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 07019caa a22011057a 4500 | ||
|---|---|---|---|
| 001 | PAPER-12147 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204221.0 | ||
| 008 | 190411s1984 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0021330670 | |
| 024 | 7 | |2 cas |a bucladesine, 16980-89-5, 362-74-3; chorionic gonadotropin, 9002-61-3; cycloheximide, 642-81-9, 66-81-9; testosterone, 58-22-0; Bucladesine, 362-74-3; Chorionic Gonadotropin; Cyclic AMP, 60-92-4; Hydroxyprogesterones; Progesterone, 57-83-0; Testosterone, 57-85-2 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a MCEND | ||
| 100 | 1 | |a Calvo, J.C. | |
| 245 | 1 | 0 | |a Effect of a second injection of human chorionic gonadotropin on the desensitized Leydig cells |
| 260 | |c 1984 | ||
| 270 | 1 | 0 | |m Calvo, J.C.; Instituto de Biologia y Medicina Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos AiresArgentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Abraham, Swerdloff, Tulchinsky, Odell, (1971) J. Clin. Endocrinol. Metab., 32, pp. 619-624 | ||
| 504 | |a Brown, Albano, Ekins, Sgherzi, (1971) Biochem. J., 121, pp. 561-562 | ||
| 504 | |a Calvo, Radicella, Charreau, (1983) Biochem. J., 212, pp. 259-264 | ||
| 504 | |a Chen, Payne, (1977) Biochem. Biophys. Res. Commun., 74, pp. 1589-1596 | ||
| 504 | |a Cigorraga, Dufau, Catt, (1978) J. Biol. Chem., 253, pp. 4297-4304 | ||
| 504 | |a D'Agata, Vicari, Aliffi, Maugeri, Mongioi, Gulizia, (1982) J. Clin. Endocrinol. Metab., 55, pp. 76-80 | ||
| 504 | |a Dehejia, Nozu, Catt, Dufau, (1982) J. Biol. Chem., 257, pp. 13781-13786 | ||
| 504 | |a Hsueh, Dufau, Catt, (1976) Biochem. Biophys. Res. Commun., 72, pp. 1145-1152 | ||
| 504 | |a Hsueh, Dufau, Catt, (1977) Proc. Natl. Acad. Sci. (U.S.A.), 74, pp. 592-595 | ||
| 504 | |a Nieschlag, Loriaux, Lipsett, (1972) Steroids, 19, pp. 669-687 | ||
| 504 | |a O'Shaughnessy, Payne, (1982) J. Biol. Chem., 257, pp. 11503-11509 | ||
| 504 | |a O'Shaughnessy, Wong, Payne, (1981) Endocrinology, 109, pp. 1061-1066 | ||
| 504 | |a Payne, Downing, Wong, (1980) Endocrinology, 106, pp. 1424-1429 | ||
| 504 | |a Payne, Wong, Vega, (1980) J. Biol. Chem., 255, pp. 1718-1722 | ||
| 504 | |a Risbridger, Robertson, de Kretser, (1982) Endocrinology, 110, pp. 138-145 | ||
| 504 | |a Rivarola, Bergadá, Cullen, (1970) J. Clin. Endocrinol. Metab., 31, pp. 526-530 | ||
| 504 | |a Saez, Haour, Tell, Gallet, Sanchez, (1977) Mol. Pharmacol., 14, pp. 1054-1062 | ||
| 504 | |a Sharpe, (1976) Nature (London), 264, pp. 644-646 | ||
| 504 | |a Tesone, Biella de Souza Valle, Foglia, Charreau, (1976) Acta Physiol. Latinoam., 26, pp. 387-394 | ||
| 504 | |a Thorell, Johansson, (1971) Biochim. Biophys. Acta, 251, pp. 363-369 | ||
| 520 | 3 | |a Experimental evidence has demonstrated that multiple doses of LH will increase the steroidogenic capacity of Leydig cells. This work was undertaken with the aim of defining the effect of a second hCG administration on the desensitized state, measuring binding of the gonadotropin and the steroidogenic capacity of rat testes. A single injection of 200 IU hCG induced a sharp increase of plasma testosterone which was still evident 24 h later. A second peak was observed at 72 h. The in vivo refractoriness of Leydig cells between 24 and 72 h after the single injection was proved by the fact that a second administration of hCG, 2 h before sacrifice, did not induce any increase in plasma testosterone. A second administration of 200 IU hCG, 48 h after the first injection, showed a similar pattern but on the 5th day there was an increased stimulation of testosterone production with respect to that obtained after a single dose of hCG. The in vitro studies on testicular binding capacity and steroidogenic responsiveness showed that the second administration of hCG, 48 h after the first injection, maintained the testicular binding capacity at the lowest level and the 'adenylate cyclase desensitization' but restored the steroidogenic capacity to even supramaximal values, compared to normal rats, 3 days after this second hCG administration. These results would support a dissociation between receptor loss and maximal testosterone synthesis as well as possibly indicating an alternative pathway different from the classical. © 1984. |l eng | |
| 536 | |a Detalles de la financiación: National Research Council | ||
| 536 | |a Detalles de la financiación: * Established Investigator from the National Research Council, Argentina. Address for correspondence: Dr. Juan C. Calvo, Instituto de Biologia y Medicina Experimental, Obligado 2490, Buenos Aires 1428 (Argentina). ** Research Fellow from the National Research Council, Argentina. | ||
| 593 | |a Instituto de Biologia y Medicina Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a DESENSITIZATION |
| 690 | 1 | 0 | |a HCG |
| 690 | 1 | 0 | |a TESTIS |
| 690 | 1 | 0 | |a BUCLADESINE |
| 690 | 1 | 0 | |a CHORIONIC GONADOTROPIN |
| 690 | 1 | 0 | |a CYCLOHEXIMIDE |
| 690 | 1 | 0 | |a RADIOISOTOPE |
| 690 | 1 | 0 | |a TESTOSTERONE |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a CHORIONIC GONADOTROPIN I 125 |
| 690 | 1 | 0 | |a DESENSITIZATION |
| 690 | 1 | 0 | |a DRUG EFFICACY |
| 690 | 1 | 0 | |a DRUG RECEPTOR BINDING |
| 690 | 1 | 0 | |a ENDOCRINE SYSTEM |
| 690 | 1 | 0 | |a HYDROXYPROGESTERONE H 3 |
| 690 | 1 | 0 | |a INTRAMUSCULAR DRUG ADMINISTRATION |
| 690 | 1 | 0 | |a LEYDIG CELL |
| 690 | 1 | 0 | |a MALE GENITAL SYSTEM |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PHARMACOKINETICS |
| 690 | 1 | 0 | |a PROGESTERONE H 3 |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a STEROIDOGENESIS |
| 690 | 1 | 0 | |a TESTIS |
| 690 | 1 | 0 | |a TESTOSTERONE H 3 |
| 690 | 1 | 0 | |a TESTOSTERONE RELEASE |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a BUCLADESINE |
| 690 | 1 | 0 | |a CHORIONIC GONADOTROPIN |
| 690 | 1 | 0 | |a CYCLIC AMP |
| 690 | 1 | 0 | |a DRUG RESISTANCE |
| 690 | 1 | 0 | |a HYDROXYPROGESTERONES |
| 690 | 1 | 0 | |a LEYDIG CELLS |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a PROGESTERONE |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, INBRED STRAINS |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a TESTOSTERONE |
| 653 | 0 | 0 | |a endocorion |
| 700 | 1 | |a Radicella, J.P. | |
| 700 | 1 | |a Pignataro, O.P. | |
| 700 | 1 | |a Charreau, E.H. | |
| 773 | 0 | |d 1984 |g v. 34 |h pp. 31-38 |k n. 1 |p Mol. Cell. Endocrinol. |x 03037207 |w (AR-BaUEN)CENRE-6138 |t Molecular and Cellular Endocrinology | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/0303-7207(84)90156-4 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_03037207_v34_n1_p31_Calvo |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v34_n1_p31_Calvo |y Registro en la Biblioteca Digital |
| 961 | |a paper_03037207_v34_n1_p31_Calvo |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 963 | |a VARI | ||
| 999 | |c 73100 | ||