Sensitivity of human peripheral blood mononuclear leukocytes to visible light
Overnight light exposure of cultured human peripheral blood mononuclear leukocytes [PBML], significantly increased basal [3H]thymidine incorporation and upon stimulation with phytohemagglutinin [PHA]. Melatonin (10-9 to 10-5 M) enhanced the light-induced increase of [3H]thymidine incorporation, whil...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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1995
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 09321caa a22013817a 4500 | ||
|---|---|---|---|
| 001 | PAPER-12445 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204238.0 | ||
| 008 | 190411s1995 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0029113058 | |
| 024 | 7 | |2 cas |a DNA Primers; DNA, 9007-49-2; Indoles; Melatonin, 73-31-4; Opsin; Serotonin, 50-67-9 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a LIFSA | ||
| 100 | 1 | |a Finocchiaro, L.M.E. | |
| 245 | 1 | 0 | |a Sensitivity of human peripheral blood mononuclear leukocytes to visible light |
| 260 | |c 1995 | ||
| 270 | 1 | 0 | |m Finocchiaro, L.M.E.; Laboratorio de Sustancias Vasoactivas, Instituto de Investigaciones Médicas, Universidad de Buenos Aires, Donate Alvarez 3150, 1427 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Finocchiaro, Polack, Nahmod, Glikin, (1995) accompanying paper | ||
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| 520 | 3 | |a Overnight light exposure of cultured human peripheral blood mononuclear leukocytes [PBML], significantly increased basal [3H]thymidine incorporation and upon stimulation with phytohemagglutinin [PHA]. Melatonin (10-9 to 10-5 M) enhanced the light-induced increase of [3H]thymidine incorporation, while serotonin (10-9 to 10-7 M) stimulated [3H]thymidine incorporation in the dark. The wavelengths responsible of this effect were restricted to the blue-green zone of the spectrum. The stimulatory effect of visible light on PHA-induced DNA replication had a circannual rhythm, being maximal during winter. In winter, white light also reduced melatonin and serotonin binding to PBML membranes and switched the PBML indole metabolism towards serotonin and 5-hydroxy-indole-acetic acid [HIAA] synthesis, with a concomitant decrease of melatonin production. © 1995. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Facultad de Ciencias Físicas y Matemáticas | ||
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Laboratorio de Sustancias Vasoactivas, Instituto de Investigaciones MBdicas, Universidad de Buenos Aires, Donato Alvarez 3 150, 1427 Buenos Aires, and *Institute de Investigaciones en Ingenieria Genetica y Biologia Molecular, Consejo National de Investigaciones Cientificas y TCcnicas, y Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina. | ||
| 536 | |a Detalles de la financiación: The authorsw ould like to thank Dr. G. Brown for the kind gift of the melatonina ntiserum.W e are grateful to Dr. Alejandro Paladini for advice in the determinationo f lamp and filter parameters, to Drs. Daniel Goldstein and Norberto Judewicz for critical reading of the manuscript and to BioSidus S.A. for technicals upport.T his studyw as supportedb y grants from the Consejo National de InvestigacionesC ientificas y Tecnicas (CONICET) and Universidad de Buenos Aires (UBA), Argentina. L.M.E.F. and G.C.G. are memberso f the CONICET, E.P and V.E.N. are memberso f the UBA. | ||
| 593 | |a Laboratorio de Sustancias Vasoactivas, Instituto de Investigaciones Médicas, Universidad de Buenos Aires, Donate Alvarez 3150, 1427 Buenos Aires, Argentina | ||
| 593 | |a Instituto de Investigaciones en Ingenieria Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, y Facultad de Ciencias Exactas y Naturales, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a MELATONIN |
| 690 | 1 | 0 | |a PERIPHERAL BLOOD MONONUCLEAR LEUKOCYTES |
| 690 | 1 | 0 | |a SEROTONIN |
| 690 | 1 | 0 | |a VISIBLE LIGHT |
| 690 | 1 | 0 | |a 5 HYDROXYINDOLEACETIC ACID |
| 690 | 1 | 0 | |a MELATONIN |
| 690 | 1 | 0 | |a PHYTOHEMAGGLUTININ |
| 690 | 1 | 0 | |a SEROTONIN |
| 690 | 1 | 0 | |a THYMIDINE |
| 690 | 1 | 0 | |a THYMIDINE H 3 |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DNA REPLICATION |
| 690 | 1 | 0 | |a DNA SYNTHESIS |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a LIGHT |
| 690 | 1 | 0 | |a MEMBRANE BINDING |
| 690 | 1 | 0 | |a MONOCYTE |
| 690 | 1 | 0 | |a BASE SEQUENCE |
| 690 | 1 | 0 | |a CELLS, CULTURED |
| 690 | 1 | 0 | |a DNA |
| 690 | 1 | 0 | |a DNA PRIMERS |
| 690 | 1 | 0 | |a GENE EXPRESSION |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a IN VITRO |
| 690 | 1 | 0 | |a LEUKOCYTES, MONONUCLEAR |
| 690 | 1 | 0 | |a LIGHT |
| 690 | 1 | 0 | |a MELATONIN |
| 690 | 1 | 0 | |a MOLECULAR SEQUENCE DATA |
| 690 | 1 | 0 | |a OPSIN |
| 690 | 1 | 0 | |a SEROTONIN |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 650 | 1 | 7 | |2 spines |a INDOLES |
| 700 | 1 | |a Polack, E. | |
| 700 | 1 | |a Nahmod, V.E. | |
| 700 | 1 | |a Glikin, G.C. | |
| 773 | 0 | |d 1995 |g v. 57 |h pp. 1097-1110 |k n. 11 |p Life Sci. |x 00243205 |w (AR-BaUEN)CENRE-749 |t Life Sciences | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/0024-3205(95)02055-N |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00243205_v57_n11_p1097_Finocchiaro |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v57_n11_p1097_Finocchiaro |y Registro en la Biblioteca Digital |
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