In vivo regulation of the steroidogenic activity of rat luteal cells by insulin
The aim of the present study was to determine the long-term effects of insulin treatment on luteal cell function. For this purpose, superovulated prepubertal rats were treated with insulin (group I) or vehicle (group C) for 9 days. Serum progesterone (P4) levels were increased in the insulin-treated...
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1995
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| LEADER | 15227caa a22013457a 4500 | ||
|---|---|---|---|
| 001 | PAPER-12507 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204242.0 | ||
| 008 | 190411s1995 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0028913718 | |
| 024 | 7 | |2 cas |a 20alpha dihydroprogesterone, 145-14-2; cytochrome P450, 9035-51-2; insulin, 9004-10-8; progesterone, 57-83-0; Cholesterol Side-Chain Cleavage Enzyme, EC 1.14.15.6; Dihydroprogesterone, 145-14-2; Insulin, 11061-68-0; Luteinizing Hormone, 9002-67-9; Progesterone, 57-83-0; Receptors, LH | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JSBBE | ||
| 100 | 1 | |a Stein, P. | |
| 245 | 1 | 3 | |a In vivo regulation of the steroidogenic activity of rat luteal cells by insulin |
| 260 | |c 1995 | ||
| 270 | 1 | 0 | |m Tesone, M.; Instituto de Biología y Medicina Experimental, CONICET Obligado 2490, Buenos Aires and Facultad de Ciencias Exactas y Naturales (UBA), 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Poretsky, On the paradox of insulin-induced hyperandrogenism in insulin-resistant states (1991) Endocr. Rev., 12, pp. 3-13 | ||
| 504 | |a Ciaraldi, El-Roeiy, Madar, Reichart, Olefsky, Yen, Cellular mechanisms of insulin resistance in polycystic ovarian syndrome (1992) J. Clin. Endocrinol. Metab., 75, pp. 577-583 | ||
| 504 | |a Barbieri, Ryan, Hyperandrogenism, insulin resistance, and acanthosis nigricans syndrome: a common endocrinopathy with distinct pathophysiologic features (1983) Am. J. Obstet. Gynecol., 147, pp. 90-101 | ||
| 504 | |a Barbieri, Smith, Ryan, The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism (1988) Fertil Steril, 50, pp. 197-212 | ||
| 504 | |a Poretsky, Kalin, The gonadotropic function of insulin (1987) Endocrine Rev., 8, pp. 132-141 | ||
| 504 | |a Adashi, Resnick, Svoboda, Van Wyk, A novel role for somatomedin-C in the cytodifferentiation of the ovarian granulosa cell (1984) Endocrinology, 115, pp. 1227-1229 | ||
| 504 | |a Taylor, Dons, Hernandez, Roth, Gordon, Insulin resistance associated with androgen excess in women with auto-antibodies to the insulin receptor (1982) Ann. Int. Med., 97, pp. 851-855 | ||
| 504 | |a Davoren, Hsueh, Insulin enhances FSH-stimulated steroidogenesis by cultured rat granulosa cells (1984) Molec. Cell. Endocrinol., 35, pp. 97-105 | ||
| 504 | |a Adashi, Resnick, Svoboda, Van Wyk, Somatomedin-C synergizes with follicle-stimulating hormone in the acquisition of progestin biosynthetic capacity by cultured rat granulosa cells (1985) Endocrinology, 116, pp. 2135-2142 | ||
| 504 | |a Barbieri, Makris, Ryan, Effects of insulin on steroidogenesis in cultured porcine ovarian theca (1983) Fertil. Steril., 40, pp. 237-241 | ||
| 504 | |a Veldhuis, Kolp, Toaff, Strauss, Demers, Mechanisms subserving the trophic actions of insulin on ovarian cells: in vitro studies using swine granulosa cells (1983) J. Clin. Invest., 72, pp. 1046-1057 | ||
| 504 | |a Barañao, Hammond, Multihormone regulation of steroidogenesis in cultured porcine granulosa cells: studies in serum-free medium (1985) Endocrinology, 116, pp. 2143-2151 | ||
| 504 | |a Savion, Liu, Laherty, Gospodarowicz, Factors controlling proliferation and progesterone production by bovine granulosa cells in serum-free medium (1981) Endocrinology, 109, pp. 409-420 | ||
| 504 | |a Garzo, Dorrington, Aromatase activity in human granulosa cells during follicular development and the modulation by follicle-stimulating hormone and insulin (1984) Am. J. Obstet. Gynecol., 148, pp. 657-663 | ||
| 504 | |a Mondschein, Schomberg, Growth factors modulate gonadotropin receptor induction in granulosa cell cultures (1981) Science, 211, pp. 1179-1180 | ||
| 504 | |a Adashi, Resnick, Svoboda, Van Wyk, Somatomedin-C enhances induction of luteinizing hormone receptors by follicle-stimulating hormone in cultured rat granulosa cells (1985) Endocrinology, 116, pp. 2369-2375 | ||
| 504 | |a Erickson, Casper, Hofeditz, Role of serum-free defined medium in regulation of LH receptor in cultured rat granulosa cells (1983) Molec. Cell. Endocrinol., 30, pp. 37-50 | ||
| 504 | |a Sanders, Midgley, Rat granulosa cell differentiation: an in vitro model (1982) Endocrinology, 111, pp. 614-624 | ||
| 504 | |a Ladenheim, Tesone, Charreau, Insulin action and characterization of insulin receptors in rat luteal cells (1984) Endocrinology, 115, pp. 752-756 | ||
| 504 | |a Saragüeta, Krimer, Charreau, Tesone, Insulin regulation of steroidogenic activity in rat culture luteal cells (1989) J. Steroid Biochem., 32, pp. 393-397 | ||
| 504 | |a Poretsky, Glover, Laumas, Kalin, Dunaif, The effects of experimental hyperinsulinemia on steroid secretion, ovarian [125I]insulin binding, and ovarian [125I]insulin-like growth-factor I binding in the rat (1988) Endocrinology, 122, pp. 581-585 | ||
| 504 | |a Veldhuis, Rodgers, Dee, Simpson, The insulin-like growth factor, somatomedin-C, induces the synthesis of cholesterol side-chain cleavage cytochrome P-450 and adrenodoxin in ovarian cells (1986) J. Biol. Chem., 261, pp. 2499-2502 | ||
| 504 | |a Goldring, Durica, Lifka, Hedin, Ratoosh, Miller, Orly, Richards, Cholesterol side-chain cleavage cytochrome P450 messenger ribonucleic acid: evidence for hormonal regulation in rat ovarian follicles and constitutive expression in corpora lutea (1987) Endocrinology, 120, pp. 1942-1950 | ||
| 504 | |a Magoffin, Weitsman, Effect of insulin-like growth factor-I on cholesterol side-chain cleavage cytochrome P450 messenger ribonucleic acid expression in ovarian thecainterstitial cells stimulated to differentiate in vitro (1993) Molec. Cell. Endocrinol., 96, pp. 45-51 | ||
| 504 | |a Aflalo, Meidan, The hormonal regulation of cholesterol side-chain cleavage cytochrome P450, adrenodoxin, and their messenger ribonucleic acid expression in bovine small-like and large-like luteal cells: Relationship with progesterone production (1993) Endocrinology, 132, pp. 410-416 | ||
| 504 | |a Tesone, Ladenheim, Chiauzzi, Charreau, Effect of prolactin on the steroidogenic response of rat luteal cells (1984) Molec. Cell. Endocrinol., 36, pp. 187-194 | ||
| 504 | |a Molinolo, Lanari, Charreau, Sanjuan, Dosne Pasqualini, Mouse mammary tumors induced by medroxy-progesterone acetate: immunohystochemistry and hormonal receptors (1987) J. Natn. Cancer. Inst., 79, pp. 1341-1350 | ||
| 504 | |a Charreau, Calvo, Tesone, Biella de Souza Valle, Barañao, Insulin regulation of Leydig cell luteinizing hormone receptors (1978) J. Biol. Chem., 253, pp. 2504-2506 | ||
| 504 | |a Moyle, Netburn, Cosgrove, Krieger, Bahl, HCG-Leydig cell functional binding kinetics (1980) Threshold and nonlinearity in response, 238, pp. E293-E302. , Am. J. Physiol | ||
| 504 | |a Guerrero, Stein, Asch, Polak de Fried, Tesone, Effect of a gonadotropin-releasing hormone agonist on luteinizing hormone receptors and steroidogenesis in ovarian cells (1993) Fertil. Steril., 59, pp. 803-809 | ||
| 504 | |a Laemmli, Cleavage of structural proteins during the assembly of the head of the bacteriophage T4 (1970) Nature, 227, pp. 680-688 | ||
| 504 | |a Lowry, Rosebrough, Farr, Randall, Protein measurement with the Folin phenol reagent (1951) J. Biol. Chem., 193, pp. 265-275 | ||
| 504 | |a Abraham, Swerdloff, Tulchinsky, Odell, Radioimmunoassay of plasma progesterone (1971) J. Clin. Endocrinol. Metab., 32, pp. 619-624 | ||
| 504 | |a Tesone, Ladenheim, Oliveira-Filho, Chiauzzi, Foglia, Charreau, Ovarian disfunction in streptozotocin-induced diabetic rats (1983) Proc. Soc. Exp. Biol. Med., 174, pp. 123-130. , 2nd Edition | ||
| 504 | |a Adashi, Resnick, D'Ercole, Svoboda, Van Wyk, Insulin-like growth factors as intravarian regulators of granulosa cell growth and function (1985) Endocr. Rev., 6, pp. 400-420 | ||
| 504 | |a Talavera, Menon, Studies on rat luteal cell response to insulin-like growth factor I (IGF-I): identification of a specific cell membrane receptor for IGF-I in the luteinized rat ovary (1991) Endocrinology, 129, pp. 1340-1346 | ||
| 504 | |a Parmer, Roberts, Jr., LeRoith, Adashi, Khan, Solan, Nelson, Gibori, Expression, action, and steroidal regulation of insulin-like growth factor-I (IGF-I) and IGF-I receptor in the rat corpus luteum: their differential role in the two cell populations forming the corpus luteum (1991) Endocrinology, 129, pp. 2924-2932 | ||
| 504 | |a Conti, Harwood, Hsueh, Dufau, Catt, Gonadotropin-induced loss of hormone receptors and desensitization of adenylate cyclase in the ovary (1976) J. Biol. Chem., 251, pp. 7729-7731 | ||
| 504 | |a Sen, Azhar, Menon, Receptor-mediated gonadotropin action in the ovary (1979) Desensitization of gonadotropin binding sites, activation of adenosine 3′,5′-cyclic monophosphate-dependent protein kinase(s), and regulation of steroidogenesis in the ovary, 254, pp. 5664-5671. , J. Biol. Chem | ||
| 504 | |a LaPolt, Oikawa, Jia, Dargan, Hsueh, Gonadotropin-induced up- and down-regulation of rat ovarian LH receptor message levels during follicular growth, ovulation and luteinization (1990) Endocrinology, 126, pp. 3277-3279 | ||
| 504 | |a Lu, Peegel, Mosier, Menon, Loss of lutropin/human chorionic gonadotropin receptor messenger ribonucleic acid during ligand-induced down-regulation occurs post transcriptionally (1993) Endocrinology, 132, pp. 235-240 | ||
| 504 | |a Lakkakorpi, Pietilä, Aatsinki, Rajaniemi, Human chorionic gonadotrophin (CG)-induced down-regulation of the rat luteal LH/CG receptor results in part from the down-regulation of its synthesis, involving increased alternative processing of the primary transcript (1993) J. Molec. Endocrinol., 10, pp. 153-162 | ||
| 504 | |a Chen, Gao, Shelton, Hatmaker, Coordinated receptor regulation in ovarian granulosa cells (1987) Advances in Experimental Medicine and Biology, pp. 703-707. , V.B. Mahesh, D.S. Dhindsa, E. Anderson, S.P. Kalra, Plenum Press, NY | ||
| 504 | |a Lane, Chen, Heterologous down-modulation of luteinizing hormone receptors by prolactin: a flow cytometry study (1991) Endocrinology, 128, pp. 1833-1840 | ||
| 504 | |a Hall, Cellular organization for steroidogenesis (1984) Int. Rev. Cytol., 86, pp. 53-95 | ||
| 504 | |a Lieberman, Greenfield, Wolfson, A heuristic proposal for understanding steroidogenic processes (1984) Endocrine Rev., 5, pp. 128-148 | ||
| 504 | |a Waterman, Simpson, Regulation of the biosynthesis of cytochromes P-450 involved in steroid hormone synthesis (1985) Molec. Cell. Endocrinol., 39, pp. 81-89 | ||
| 504 | |a DuBois, Simpson, Kramer, Waterman, Induction of synthesis of cholesterol side chain cleavage cytochrome P-450 by adrenocorticotropin in cultured bovine adrenocortical cells (1981) J. Biol. Chem., 256, pp. 7000-7005 | ||
| 504 | |a Veldhuis, Klase, Strauss, III, Hammond, Facilitative interactions between estradiol and luteinizing hormone in the regulation of progesterone production by cultured swine granulosa cells: relation to cellular cholesterol metabolism (1982) Endocrinology, 111, pp. 441-447 | ||
| 520 | 3 | |a The aim of the present study was to determine the long-term effects of insulin treatment on luteal cell function. For this purpose, superovulated prepubertal rats were treated with insulin (group I) or vehicle (group C) for 9 days. Serum progesterone (P4) levels were increased in the insulin-treated group (55 ± 10 vs 134 ± 31 ng/ml, P < 0.05). Isolated luteal cells were incubated 3 h, and P4 and 20α-hydroxy-progesterone (20α-OH-P) were measured in the incubation media. A decrease in P4 levels and an increase in 20α-OH-P values [P4 (ng/ml): C = 26.6 ± 0.3; I = 20 ± 2; 20α-OH-P (ng/ml): C = 62 ± 2; I: 120 ± 7; P < 0.01] were observed in group I. In addition, progestagen (P4 + 20α-OH-P) levels were higher in group I (C = 88 ± 2; I = 140 ± 9 ng/ml; P < 0.001). When cytochrome P450SCC contents were measured by immunoblotting, a marked increase was observed in luteal cells obtained from group I. LH receptor numbers were decreased in luteal cells isolated from group I (C = 388,834 ± 14,146; I = 303,057 ± 13,392 sites/cell; P < 0.001) with a concomitantly diminished LH responsiveness. It is concluded that in vivo treatment of superovulated rats with insulin increases luteal progestagen production by increasing the content of cytochrome P450SCC. © 1995. |l eng | |
| 536 | |a Detalles de la financiación: National Research Council | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, T6cnicas, 0488/88 | ||
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires, UBA EX-149 | ||
| 536 | |a Detalles de la financiación: Acknowledgements--We thank Dr Eduardo H. Charreau for providing labelled hCG, and Liliana B. Dain for help with statistical analysis. We also thank the National Hormone and Pituitary Program for the generous supply of human LH. Supported by grants from Consejo Nacional de Investigaciones Cientificas y T6cnicas (0488/88--National Research Council, Buenos Aires, Argentina), Roemmers Foundation (Buenos Aires, Argentina) and Universidad de Buenos Aires (UBA EX-149---Buenos Aires, Argentina). | ||
| 593 | |a Instituto de Biología y Medicina Experimental, CONICET Obligado 2490, Buenos Aires and Facultad de Ciencias Exactas y Naturales (UBA), 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a 20ALPHA DIHYDROPROGESTERONE |
| 690 | 1 | 0 | |a CYTOCHROME P450 |
| 690 | 1 | 0 | |a INSULIN |
| 690 | 1 | 0 | |a LUTEINIZING HORMONE RECEPTOR |
| 690 | 1 | 0 | |a PROGESTERONE |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a IMMUNOBLOTTING |
| 690 | 1 | 0 | |a LUTEAL CELL |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a STEROIDOGENESIS |
| 690 | 1 | 0 | |a SUBCUTANEOUS DRUG ADMINISTRATION |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME |
| 690 | 1 | 0 | |a CORPUS LUTEUM |
| 690 | 1 | 0 | |a DIHYDROPROGESTERONE |
| 690 | 1 | 0 | |a DOSE-RESPONSE RELATIONSHIP, DRUG |
| 690 | 1 | 0 | |a DRUG INTERACTIONS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a INSULIN |
| 690 | 1 | 0 | |a LUTEINIZING HORMONE |
| 690 | 1 | 0 | |a OVULATION |
| 690 | 1 | 0 | |a PROGESTERONE |
| 690 | 1 | 0 | |a PUBERTY |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a RECEPTORS, LH |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 700 | 1 | |a Bussmann, L.E. | |
| 700 | 1 | |a Tesone, M. | |
| 773 | 0 | |d 1995 |g v. 52 |h pp. 329-335 |k n. 4 |p J. Steroid Biochem. Mol. Biol. |x 09600760 |w (AR-BaUEN)CENRE-5799 |t Journal of Steroid Biochemistry and Molecular Biology | |
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