Isobutylmethylxanthine and other classical cyclic nucleotide phosphodiesterase inhibitors affect cAMP-dependent protein kinase activity
The effect of 17 inhibitors of cyclic nucleotide phosphodiesterases (PDEs) was assayed on cAMP binding activity of Mucor rouxii protein kinase A (PKA), on PKA activity in the absence of cAMP and on free catalytic subunit (C) activity. Isobutylmethylxanthine (IBMX), SQ 20,009 and cilostamide, at 0.2...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1993
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 08177caa a22012977a 4500 | ||
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| 001 | PAPER-143 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518202931.0 | ||
| 008 | 190411s1993 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0027359971 | |
| 024 | 7 | |2 cas |a 1-Methyl-3-isobutylxanthine, 28822-58-4; cilostamide, 68550-75-4; Cyclic AMP, 60-92-4; Cyclic AMP-Dependent Protein Kinases, EC 2.7.1.37; Etazolate, 51022-77-6; Phosphodiesterase Inhibitors; Quinolones | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a CESIE | ||
| 100 | 1 | |a Tomes, C. | |
| 245 | 1 | 0 | |a Isobutylmethylxanthine and other classical cyclic nucleotide phosphodiesterase inhibitors affect cAMP-dependent protein kinase activity |
| 260 | |c 1993 | ||
| 270 | 1 | 0 | |m Silvia, M.; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Guthmann, Pastori, Moreno, (1990) Cellular Signalling, 2, pp. 395-402 | ||
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| 504 | |a Jiménez, Lechuga, Alonso, Benítez, Ros, Moreno, Dipyridamole stimulates types II cAMP-dependent protein kinase in vitro (1992) Molecular and Cellular Biochemistry, 109, pp. 9-15 | ||
| 504 | |a Taylor, Bubis, Toner-Webb, Saraswat, First, Buechler, Knighton, Sowadski, (1989) FASEB J., 2, pp. 2677-2685 | ||
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| 504 | |a Zhou, Newsholme, Torphy, (1992) J. Pharmac. exp. Ther., 261, pp. 1260-1267 | ||
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| 520 | 3 | |a The effect of 17 inhibitors of cyclic nucleotide phosphodiesterases (PDEs) was assayed on cAMP binding activity of Mucor rouxii protein kinase A (PKA), on PKA activity in the absence of cAMP and on free catalytic subunit (C) activity. Isobutylmethylxanthine (IBMX), SQ 20,009 and cilostamide, at 0.2 mM, behaved as partial agonists of cAMP since they inhibited binding of 0.15 μM [ 3 H]cAMP to the regulatory subunit (R), stimulated slightly PKA activity in the absence of cAMP and did not modify C activity. Amrinone at 0.2 mM inhibited C activity competitively towards ATP. These four compounds displayed the same effects when assayed on eukaryotic protein kinase A types I (PKI) and II (PKII). The combined effect of IBMX and cAMP was analysed on Mucor PKA. Under dissociating conditions (+ 0.5 M NaCl) IBMX antagonized activation by low concentrations of cAMP, while in the absence of NaCl, IBMX potentiated the stimulating activity of cAMP. © 1993. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Third World Academy of Sciences | ||
| 536 | |a Detalles de la financiación: Acknowledgements--We are grateful to V. ZAREMBEl~G and E. l~l~W,X for discussion of results and critical reading of the manuscript as well as to I. COLONNA for assistance with the statistical analysis. This work was supported by a grant from the University of Buenos Aires (UBA) and the Third World Academy of Sciences (TWAS). S.R. is a graduate fellow from UBA. | ||
| 593 | |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a INHIBITORS |
| 690 | 1 | 0 | |a ISOBUTYLMETHYLXANTHINE |
| 690 | 1 | 0 | |a PHOSPHODIESTERASE |
| 690 | 1 | 0 | |a PROTEIN KINASE A |
| 690 | 1 | 0 | |a 1 ETHYL 4 HYDRAZINO 1H PYRAZOLO[3,4 B]PYRIDINE 5 CARBOXYLIC ACID ETHYL ESTER |
| 690 | 1 | 0 | |a 2 AMINO 4,5 DIHYDRO 6 METHYL 5 OXO 4 PROPYL 1,2,4 TRIAZOLO[1,5 A]PYRIMIDINE |
| 690 | 1 | 0 | |a 4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE |
| 690 | 1 | 0 | |a 4,5 DIHYDRO 6 [4 (1H IMIDAZOL 1 YL)PHENYL] 5 METHYL 3(2H) PYRIDAZINONE |
| 690 | 1 | 0 | |a 6 [4 (3 METHYLUREIDO)PHENYL] 3(2H) PYRIDAZINONE |
| 690 | 1 | 0 | |a AMRINONE |
| 690 | 1 | 0 | |a CILOSTAMIDE |
| 690 | 1 | 0 | |a CILOSTAZOL |
| 690 | 1 | 0 | |a CYCLIC AMP DEPENDENT PROTEIN KINASE |
| 690 | 1 | 0 | |a DIPYRIDAMOLE |
| 690 | 1 | 0 | |a ETAZOLATE |
| 690 | 1 | 0 | |a IMAZODAN |
| 690 | 1 | 0 | |a ISOBUTYLMETHYLXANTHINE |
| 690 | 1 | 0 | |a MILRINONE |
| 690 | 1 | 0 | |a PAPAVERINE |
| 690 | 1 | 0 | |a PHOSPHODIESTERASE INHIBITOR |
| 690 | 1 | 0 | |a ROLIPRAM |
| 690 | 1 | 0 | |a SQ 65442 |
| 690 | 1 | 0 | |a THEOPHYLLINE |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a ENZYME INHIBITION |
| 690 | 1 | 0 | |a LIGAND BINDING |
| 690 | 1 | 0 | |a MUCOR |
| 690 | 1 | 0 | |a MUCOR ROUXII |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 690 | 1 | 0 | |a 1-METHYL-3-ISOBUTYLXANTHINE |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a CYCLIC AMP |
| 690 | 1 | 0 | |a CYCLIC AMP-DEPENDENT PROTEIN KINASES |
| 690 | 1 | 0 | |a ETAZOLATE |
| 690 | 1 | 0 | |a IN VITRO |
| 690 | 1 | 0 | |a MUCOR |
| 690 | 1 | 0 | |a MYOCARDIUM |
| 690 | 1 | 0 | |a PHOSPHODIESTERASE INHIBITORS |
| 690 | 1 | 0 | |a QUINOLONES |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a AMYLOMYCES ROUXII |
| 690 | 1 | 0 | |a EUKARYOTA |
| 690 | 1 | 0 | |a MUCOR |
| 653 | 0 | 0 | |a ci 914, warner lambert; ci 930, warner lambert; ici 118233, ici; ici 63197, ici; opc 3689, china otsuka pharmaceutical; ro 20 1724, hoffmann la roche; sq 20006, squibb laboratories; sq 20009, squibb laboratories; sq 65442, squibb laboratories |
| 700 | 1 | |a Rossi, S. | |
| 700 | 1 | |a Moreno, S. | |
| 773 | 0 | |d 1993 |g v. 5 |h pp. 615-621 |k n. 5 |p Cell. Signal. |x 08986568 |w (AR-BaUEN)CENRE-4136 |t Cellular Signalling | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027359971&doi=10.1016%2f0898-6568%2893%2990056-R&partnerID=40&md5=bd03542cc05b204e68fabb71c1473c17 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/0898-6568(93)90056-R |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_08986568_v5_n5_p615_Tomes |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08986568_v5_n5_p615_Tomes |y Registro en la Biblioteca Digital |
| 961 | |a paper_08986568_v5_n5_p615_Tomes |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 61096 | ||