Sp1 transcription factor is a modulator of estradiol leptin induction in placental cells
Introduction Pleiotropic effects of leptin have been identified in reproduction and pregnancy, particularly in the placenta, where it functions as an autocrine hormone. The synthesis of leptin in normal trophoblastic cells is regulated by different endogenous biochemical agents, but the regulation o...
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2017
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| 024 | 7 | |2 scopus |a 2-s2.0-85023606772 | |
| 024 | 7 | |2 cas |a estradiol, 50-28-2; fulvestrant, 129453-61-8; Estradiol; Estrogen Receptor alpha; fulvestrant; Leptin; Sp1 Transcription Factor | |
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| 100 | 1 | |a Schanton, M. | |
| 245 | 1 | 0 | |a Sp1 transcription factor is a modulator of estradiol leptin induction in placental cells |
| 260 | |b W.B. Saunders Ltd |c 2017 | ||
| 270 | 1 | 0 | |m Varone, C.; Departamento de Química Biológica, IQUIBICEN- CONICET, Ciudad Universitaria Pabellón 2, piso 4, Argentina; email: cvarone@qb.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Introduction Pleiotropic effects of leptin have been identified in reproduction and pregnancy, particularly in the placenta, where it functions as an autocrine hormone. The synthesis of leptin in normal trophoblastic cells is regulated by different endogenous biochemical agents, but the regulation of placental leptin expression is still poorly understood. We have previously reported that 17β-estradiol up-regulates placental leptin expression through genomic and nongenomic mechanisms. Methods To improve the understanding of estrogen receptor mechanisms in regulating leptin gene expression, we examined Sp1 transcription factor effect on estradiol leptin induction in human BeWo cell line. Results We demonstrated that Sp1 induces leptin expression determined by qRT-PCR, Western blot and transient transfection experiments. We also found that estradiol induction effect on leptin expression is enhanced by the over expression of Sp1 factor. Moreover, estradiol effect was not evidenced when Sp1 binding site on leptin promoter is mutated, suggesting that estradiol action is dependent on Sp1. On the other hand we showed data that demonstrate that Sp1 induction of leptin expression is insensitive to the antiestrogen ICI 182 780. By over expression experiments, we have also found that Sp1 effect on leptin expression could be mediated by estrogen receptor alpha. Supporting this idea, the downregulation of estrogen receptor alpha level through a specific siRNA, abolished Sp1 effect on leptin expression. Discussion Taken together all these evidences suggest a cooperative behavior between estrogen receptor alpha and Sp1 transcription factors to induce leptin transcription. © 2017 Elsevier Ltd |l eng | |
| 536 | |a Detalles de la financiación: Instituto de Salud Carlos III, PI09/00119, PI12/01172 | ||
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires, UBACYT 2012-2015- 20020110100022 | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica, PICT 2012-1366 | ||
| 536 | |a Detalles de la financiación: Federación Española de Enfermedades Raras, FEDER | ||
| 536 | |a Detalles de la financiación: This work was supported by the Universidad de Buenos Aires (UBACYT 2012-2015- 20020110100022), the ANPCyT (PICT 2012-1366), Argentina and the Spanish Grant from ISCIII (PI09/00119 and PI12/01172), co-funded in part by FEDER, Spain. | ||
| 593 | |a Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Ciudad Universitaria Pabellón 2, 4° piso, Buenos Aires, 1428, Argentina | ||
| 593 | |a Universidad de Buenos Aires, CONICET, Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Ciudad Universitaria Pabellón 2, 4° piso, Buenos Aires, 1428, Argentina | ||
| 593 | |a Departamento de Bioquímica Médica y Biología Molecular, Hospital Universitario Virgen Macarena, Facultad de Medicina, Universidad de Sevilla, Avenida Sánchez Pizjúan 4, Sevilla, 41009, Spain | ||
| 593 | |a Hospital Nacional Profesor Alejandro Posadas, Buenos Aires, Argentina | ||
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