AR-12 Inhibits Multiple Chaperones Concomitant With Stimulating Autophagosome Formation Collectively Preventing Virus Replication
We have recently demonstrated that AR-12 (OSU-03012) reduces the function and ATPase activities of multiple HSP90 and HSP70 family chaperones. Combined knock down of chaperones or AR-12 treatment acted to reduce the expression of virus receptors and essential glucosidase proteins. Combined knock dow...
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| Otros Autores: | , , , , , , , , , , , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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Wiley-Liss Inc.
2016
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| LEADER | 16691caa a22017537a 4500 | ||
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| 001 | PAPER-15702 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204629.0 | ||
| 008 | 190411s2016 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84975074244 | |
| 024 | 7 | |2 cas |a adenosine triphosphatase, 37289-25-1, 9000-83-3; gamma glutamyltransferase, 85876-02-4; glucosidase, 9033-06-1; lactate dehydrogenase, 9001-60-9; pazopanib, 444731-52-6, 635702-64-6; sorafenib, 284461-73-0 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JCLLA | ||
| 100 | 1 | |a Booth, L. | |
| 245 | 1 | 0 | |a AR-12 Inhibits Multiple Chaperones Concomitant With Stimulating Autophagosome Formation Collectively Preventing Virus Replication |
| 260 | |b Wiley-Liss Inc. |c 2016 | ||
| 270 | 1 | 0 | |m Dent, P.; Department of Biochemistry and Molecular Biology, Virginia Commonwealth UniversityUnited States; email: pdent@vcu.edu |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a We have recently demonstrated that AR-12 (OSU-03012) reduces the function and ATPase activities of multiple HSP90 and HSP70 family chaperones. Combined knock down of chaperones or AR-12 treatment acted to reduce the expression of virus receptors and essential glucosidase proteins. Combined knock down of chaperones or AR-12 treatment inactivated mTOR and elevated ATG13 S318 phosphorylation concomitant with inducing an endoplasmic reticulum stress response that in an eIF2α—dependent fashion increased Beclin1 and LC3 expression and autophagosome formation. Over-expression of chaperones prevented the reduction in receptor/glucosidase expression, mTOR inactivation, the ER stress response, and autophagosome formation. AR-12 reduced the reproduction of viruses including Mumps, Influenza, Measles, Junín, Rubella, HIV (wild type and protease resistant), and Ebola, an effect replicated by knock down of multiple chaperone proteins. AR-12—stimulated the co-localization of Influenza, EBV and HIV virus proteins with LC3 in autophagosomes and reduced viral protein association with the chaperones HSP90, HSP70, and GRP78. Knock down of Beclin1 suppressed drug-induced autophagosome formation and reduced the anti-viral protection afforded by AR-12. In an animal model of hemorrhagic fever virus, a transient exposure of animals to low doses of AR-12 doubled animal survival from ∼30% to ∼60% and suppressed liver damage as measured by ATL, GGT and LDH release. Thus through inhibition of chaperone protein functions; reducing the production, stability and processing of viral proteins; and stimulating autophagosome formation/viral protein degradation, AR-12 acts as a broad-specificity anti-viral drug in vitro and in vivo. We argue future patient studies with AR-12 are warranted. J. Cell. Physiol. 231: 2286–2302, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc. |l eng | |
| 593 | |a Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, United States | ||
| 593 | |a School of Biological Sciences and Illawarra Health and Medical Research Institute, University of Wollongong, NSW, Australia | ||
| 593 | |a Molecular and Translational Science, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Frederick, MD, United States | ||
| 593 | |a Arno Therapeutics, Flemington, NJ, United States | ||
| 593 | |a Department of Otolaryngology, University of Arizona Ear Institute, Tucson, AZ, United States | ||
| 593 | |a FCEN-UBA, Ciudad Universitaria, Pabellón 2 Piso 4, lab QB-17, Buenos Aires, Argentina | ||
| 593 | |a Institute of Biomedicine and CIBEREhd, University of León, León, Spain | ||
| 690 | 1 | 0 | |a 2 AMINO N [4 [5 (2 PHENANTHRENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]PHENYL]ACETAMIDE |
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| 653 | 0 | 0 | |a ar 12; osu 03012, Selleck, United States |
| 700 | 1 | |a Roberts, J.L. | |
| 700 | 1 | |a Ecroyd, H. | |
| 700 | 1 | |a Tritsch, S.R. | |
| 700 | 1 | |a Bavari, S. | |
| 700 | 1 | |a Reid, S.P. | |
| 700 | 1 | |a Proniuk, S. | |
| 700 | 1 | |a Zukiwski, A. | |
| 700 | 1 | |a Jacob, A. | |
| 700 | 1 | |a Sepúlveda, C.S. | |
| 700 | 1 | |a Giovannoni, F. | |
| 700 | 1 | |a García, C.C. | |
| 700 | 1 | |a Damonte, E. | |
| 700 | 1 | |a González-Gallego, J. | |
| 700 | 1 | |a Tuñón, M.J. | |
| 700 | 1 | |a Dent, P. | |
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