Increased Expression of Aquaporin 9 in Trophoblast from Gestational Diabetic Patients
Gestational diabetes mellitus is the most frequent pathophysiological alteration in pregnancy, increasing the incidence of complications in both mother and fetus. The macrosomia that occurs in these fetuses may be related with some changes in nutrient transport mechanism in placenta. The presence of...
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| Otros Autores: | , , , , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
Georg Thieme Verlag
2016
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 09127caa a22012377a 4500 | ||
|---|---|---|---|
| 001 | PAPER-15811 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204637.0 | ||
| 008 | 190411s2016 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84964319037 | |
| 024 | 7 | |2 cas |a glycerol, 56-81-5; aquaporin, 215587-75-0; AQP9 protein, human; Aquaporins; RNA, Messenger | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a HMMRA | ||
| 100 | 1 | |a Vilariño-García, T. | |
| 245 | 1 | 0 | |a Increased Expression of Aquaporin 9 in Trophoblast from Gestational Diabetic Patients |
| 260 | |b Georg Thieme Verlag |c 2016 | ||
| 270 | 1 | 0 | |m Sánchez-Margalet, V.; Department of Clinical Biochemistry, Medical School, University of Seville, Virgen Macarena University Hospital, Av. Dr. Fedriani 3, Spain; email: margalet@us.es |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Fujiyoshi, Y., Mitsuoka, K., De Groot, B.L., Philippsen, A., Grubmuller, H., Agre, P., Engel, A., Structure and function of water channels (2002) Curr Opin Struct Biol, 12, pp. 509-515 | ||
| 504 | |a Verkman, A.S., Aquaporins: Translating bench research to human disease (2009) J Exp Biol, 212, pp. 1707-1715 | ||
| 504 | |a Damiano, A.E., Review: Water channel proteins in the human placenta and fetal membranes (2011) Placenta, 32, pp. S207-S211 | ||
| 504 | |a Damiano, A., Zotta, E., Goldstein, J., Reisin, I., Ibarra, C., Water channel proteins AQP3 and AQP9 are present in syncytiotrophoblast of human term placenta (2001) Placenta, 22, pp. 776-781 | ||
| 504 | |a Damiano, A.E., Zotta, E., Ibarra, C., Functional and molecular expression of AQP9 channel and UT-A transporter in normal and preeclamptic human placentas (2006) Placenta, 27, pp. 1073-1081 | ||
| 504 | |a Hua, Y., Jiang, W., Zhang, W., Shen, Q., Chen, M., Zhu, X., Expression and significance of aquaporins during pregnancy (2013) Front Biosci (Landmark Ed), 18, pp. 1373-1383 | ||
| 504 | |a Barnes-Powell, L.L., Infants of diabetic mothers: The effects of hyperglycemia on the fetus and neonate (2007) Neonatal Netw, 26, pp. 283-290 | ||
| 504 | |a Gabbe, S.G., Gestational diabetes mellitus (1986) N Engl J Med, 315, pp. 1025-1026 | ||
| 504 | |a Osmond, D.T., Nolan, C.J., King, R.G., Brennecke, S.P., Gude, N.M., Effects of gestational diabetes on human placental glucose uptake, transfer, and utilisation (2000) Diabetologia, 43, pp. 576-582 | ||
| 504 | |a Jansson, N., Pettersson, J., Haafiz, A., Ericsson, A., Palmberg, I., Tranberg, M., Ganapathy, V., Jansson, T., Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet (2006) J Physiol, 576, pp. 935-946 | ||
| 504 | |a Lepercq, J., Cauzac, M., Lahlou, N., Timsit, J., Girard, J., Auwerx, J., Hauguel-De, M.S., Overexpression of placental leptin in diabetic pregnancy: A critical role for insulin (1998) Diabetes, 47, pp. 847-850 | ||
| 504 | |a Sagawa, N., Yura, S., Itoh, H., Mise, H., Kakui, K., Korita, D., Takemura, M., Fujii, S., Role of leptin in pregnancy-a review (2002) Placenta, 23, pp. S80-S86. , Suppl A | ||
| 504 | |a Perez-Perez, A., Maymo, J.L., Gambino, Y.P., Guadix, P., Duenas, J.L., Varone, C.L., Sanchez-Margalet, V., Activated translation signaling in placenta from pregnant women with gestational diabetes mellitus: Possible role of leptin (2013) Horm Metab Res, 45, pp. 436-442 | ||
| 504 | |a Perez-Perez, A., Guadix, P., Maymo, J., Duenas, J.L., Varone, C., Fernandez-Sanchez, M., Sanchez-Margalet, V., Insulin and Leptin Signaling in Placenta from Gestational Diabetic Subjects (2016) Horm Metab Res, 48, pp. 62-69 | ||
| 504 | |a Castro, P.M., Farina, M., Dietrich, V., Aban, C., Szpilbarg, N., Zotta, E., Damiano, A.E., Evidence for insulin-mediated control of AQP9 expression in human placenta (2011) Placenta, 32, pp. 1050-1056 | ||
| 504 | |a Rodriguez, A., Catalan, V., Gomez-Ambrosi, J., Fruhbeck, G., Aquaglyceroporins serve as metabolic gateways in adiposity and insulin resistance control (2011) Cell Cycle, 10, pp. 1548-1556 | ||
| 504 | |a Perez-Perez, A., Maymo, J., Duenas, J.L., Goberna, R., Calvo, J.C., Varone, C., Sanchez-Margalet, V., Leptin prevents apoptosis of trophoblastic cells by activation of MAPK pathway (2008) Arch Biochem Biophys, 477, pp. 390-395 | ||
| 504 | |a Perez-Perez, A., Sanchez-Jimenez, F., Maymo, J., Duenas, J.L., Varone, C., Sanchez-Margalet, V., Role of leptin in female reproduction (2015) Clin Chem Lab Med, 53, pp. 15-28 | ||
| 520 | 3 | |a Gestational diabetes mellitus is the most frequent pathophysiological alteration in pregnancy, increasing the incidence of complications in both mother and fetus. The macrosomia that occurs in these fetuses may be related with some changes in nutrient transport mechanism in placenta. The presence of aquaporin 9, an aquaglyceroporin, has previously been demonstrated in placenta. We raised the question whether aquaporin 9 expression may be upregulated in placenta from gestational diabetes, thus providing a faster transport of glycerol and water through placenta. We studied 21 placentas (13 controls and 8 gestational diabetes) from cesarean delivery at term. The expression of aquaporin 9 was analyzed by quantitative PCR, immunoblot, and immunohistochemistry. The median values from quantitative PCR were compared by nonparametric tests for independent samples (Mann-Whitney U-test). We have found that trophoblast from gestational diabetes express higher amount of aquaporin 9, which was found statistically significant (p<0.05). The increase in aquaporin 9 expression was confirmed by immunoblot, and localization in the syncytiotrophoblast was checked by immunohistochemistry. The increase in aquaporin 9 expression in placenta from gestational diabetes may contribute to the higher transport rate in this pathology of pregnancy. © Georg Thieme Verlag KG Stuttgart, New York. |l eng | |
| 593 | |a Department of Clinical Biochemistry, Medical School, University of Seville, Virgen Macarena University Hospital, Av. Dr. Fedriani 3, Seville, 41071, Spain | ||
| 593 | |a Department of Biological Sciences, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Department of Biological Chemistry, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Valencian Infertility Institute (IVI), Seville, Spain | ||
| 593 | |a Obstetrics and Gynecology Department, Virgen Macarena University Hospital, Medical School, University of Seville, Seville, Spain | ||
| 690 | 1 | 0 | |a AQP9 |
| 690 | 1 | 0 | |a AQUAPORINS |
| 690 | 1 | 0 | |a GESTATIONAL DIABETES MELLITUS |
| 690 | 1 | 0 | |a AQUAPORIN 9 |
| 690 | 1 | 0 | |a GLYCEROL |
| 690 | 1 | 0 | |a AQP9 PROTEIN, HUMAN |
| 690 | 1 | 0 | |a AQUAPORIN |
| 690 | 1 | 0 | |a MESSENGER RNA |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CESAREAN SECTION |
| 690 | 1 | 0 | |a CLINICAL ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DIABETIC PATIENT |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GENE EXPRESSION |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN TISSUE |
| 690 | 1 | 0 | |a IMMUNOBLOTTING |
| 690 | 1 | 0 | |a IMMUNOHISTOCHEMISTRY |
| 690 | 1 | 0 | |a PREGNANCY DIABETES MELLITUS |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a QUANTITATIVE ANALYSIS |
| 690 | 1 | 0 | |a REAL TIME POLYMERASE CHAIN REACTION |
| 690 | 1 | 0 | |a SYNCYTIOTROPHOBLAST |
| 690 | 1 | 0 | |a UPREGULATION |
| 690 | 1 | 0 | |a WATER TRANSPORT |
| 690 | 1 | 0 | |a GENE EXPRESSION REGULATION |
| 690 | 1 | 0 | |a GENETICS |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a PATHOLOGY |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a PREGNANCY DIABETES MELLITUS |
| 690 | 1 | 0 | |a PROTEIN TRANSPORT |
| 690 | 1 | 0 | |a TROPHOBLAST |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a AQUAPORINS |
| 690 | 1 | 0 | |a DIABETES, GESTATIONAL |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GENE EXPRESSION REGULATION |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a PROTEIN TRANSPORT |
| 690 | 1 | 0 | |a RNA, MESSENGER |
| 690 | 1 | 0 | |a TROPHOBLASTS |
| 650 | 1 | 7 | |2 spines |a PLACENTA |
| 650 | 1 | 7 | |2 spines |a PLACENTA |
| 700 | 1 | |a Pérez-Pérez, A. | |
| 700 | 1 | |a Dietrich, V. | |
| 700 | 1 | |a Fernández-Sánchez, M. | |
| 700 | 1 | |a Guadix, P. | |
| 700 | 1 | |a Dueñas, J.L. | |
| 700 | 1 | |a Varone, C.L. | |
| 700 | 1 | |a Damiano, A.E. | |
| 700 | 1 | |a Sánchez-Margalet, V. | |
| 773 | 0 | |d Georg Thieme Verlag, 2016 |g v. 48 |h pp. 535-539 |k n. 8 |p Horm. Metab. Res. |x 00185043 |t Hormone and Metabolic Research | |
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| 856 | 4 | 0 | |u https://doi.org/10.1055/s-0042-105152 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00185043_v48_n8_p535_VilarinoGarcia |y Handle |
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