Ontogenesis of [3H]serotonin binding sites in the hypothalamus of the female rat: Relation to serotonin-induced LH release in moxestrol-pretreated rats
The release of luteinizing hormone (LH) evoked by exogenous serotonin (5 mg/kg, i.p.) was measured at different developmental ages in the female rat. Since LH response to serotonin is modulated by estrogen, moxestrol, a synthetic compound which does not bind to α-fetoprotein, was administered 48 h b...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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1986
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 11895caa a22011417a 4500 | ||
|---|---|---|---|
| 001 | PAPER-18183 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204933.0 | ||
| 008 | 190411s1986 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0022642316 | |
| 024 | 7 | |2 cas |a indoleamine, 56480-48-9; moxestrol, 34816-55-2; prolactin, 12585-34-1, 50647-00-2, 9002-62-4 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a DBRRD | ||
| 100 | 1 | |a Becú-Villalobos, D. | |
| 245 | 1 | 0 | |a Ontogenesis of [3H]serotonin binding sites in the hypothalamus of the female rat: Relation to serotonin-induced LH release in moxestrol-pretreated rats |
| 260 | |c 1986 | ||
| 270 | 1 | 0 | |m Libertun, C.; Instituto de Biología y Medicina Experimental, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Biegon, Bercovitz, Samuel, Serotonin receptor concentration during the estrous cycle of the rat (1980) Brain Res., 187, pp. 221-225 | ||
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| 504 | |a Cresie, Keightley, The underlying structure of the direct linear plot with application to the analysis of hormone receptor interactions (1979) J. Steroid Biochem., 11, pp. 1173-1180 | ||
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| 504 | |a Fillion, Central serotonin receptors: regulation mechanism at the molecular level (1983) Molecular Pharmacology of Neurotransmitter Receptors, pp. 115-123. , T. Segawa, H.I. Yamamura, K. Kuriyama, Raven, New York | ||
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| 504 | |a Héry, Laplante, Kordon, Participation of serotonin in the phasic release of LH. I. Evidence from pharmacological experiments (1976) Endocrinology, 99, pp. 496-505 | ||
| 504 | |a Ieri, Chen, Meites, Effects of morphine and naloxone on serum levels of luteinizing hormone and prolactin in prepubertal male and female rats (1979) Neuroendocrinology, 29, pp. 288-292 | ||
| 504 | |a Johnson, Crowley, Acute effects of estradiol on circulating luteinizing hormone and prolactin concentrations and on serotonin turnover in individual brain nuclei (1983) Endocrinology, 113, pp. 1935-1941 | ||
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| 504 | |a Lawson, Gala, The influence of pharmacological manipulation of serotonergic and dopaminergic mechanisms on plasma prolactin in ovariectomized, estrogen-treated rats (1978) Endocrinology, 102, pp. 973-981 | ||
| 504 | |a Lidov, Molliver, An immunohistochemical study of serotonin neuron development in the rat: ascending pathways and terminal fields (1982) Brain Res. Bull., 8, pp. 389-430 | ||
| 504 | |a Lidov, Molliver, Immunohistochemical study of the development of serotonergic neurons in the rat CNS (1982) Brain Res. Bull., 9, pp. 559-604 | ||
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| 504 | |a Moguilevsky, Faigón, Scacchi, Szwarcfarb, Effect of serotoninergic system on luteinizing hormone secretion in prepubertal female rats (1985) Neuroendocrinology, 40, pp. 135-138 | ||
| 504 | |a Nelson, Herbet, Bourgoin, Glowinski, Hamon, Characteristics of central 5-HT receptors and their adaptive changes following intracerebral 5,7-dihydroxytryptamine administration in the rat (1978) Mol. Pharmacol., 14, pp. 983-995 | ||
| 504 | |a Nelson, Herbet, Enjalbert, Bockaert, Hamon, Serotonin-sensitive adenylate cyclase and [3H]-serotonin binding sites in the CNS of the rat. I and II (1980) Biochem. Pharmcol., 29, pp. 2445-2453 | ||
| 504 | |a Ness, Ruzsas, Role of the serotoninergic neuron system of the brain stem on the release of thyrotropic and luteinizing hormone (1981) J. Physiol. (London), 77, pp. 501-503 | ||
| 504 | |a Ojeda, Jameson, McCann, Developmental changes in pituitary responsiveness to luteinizing hormone-releasing hormone (LH-RH) in the female rat: ovarian-adrenal influence during the infantile period (1977) Endocrinology, 100, pp. 440-451 | ||
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| 504 | |a Savage, Frazer, Mendels, Differential effects of monoamine oxidase inhibitors and serotonin reuptake inhibitors on [3H]-serotonin receptor binding in rat brain (1979) Eur. J. Pharmacol., 58, pp. 87-88 | ||
| 504 | |a Schneider, McCann, Mono- and indoleamines and control of LH secretion (1970) Endocrinology, 86, pp. 1127-1133 | ||
| 504 | |a Steigrad, Tobler, Waser, Borbely, Effect of p-chlorophenylalanine on cerebral serotonin binding, serotonin concentration and motor activity in the rat (1978) Naunyn-Schmiedebergs Arch. Pharmacol., 305, pp. 143-148 | ||
| 504 | |a Watts, Stanley, Indoleamines in the hypothalamus and area of the midbrain raphe nuclei of male and female rats throughout postnatal development (1984) Neuroendocrinology, 38, pp. 461-466 | ||
| 504 | |a Weiner, Ganong, Role of brain monoamines and histamine in regulation of anterior pituitary secretion (1978) Physiol. Rev., 58, pp. 905-976 | ||
| 504 | |a Wuttke, Honma, Lamberts, Hohn, The role of monoamines in female puberty (1980) Fed. Proc. Fed. Am. Soc. Exp. Biol., 39, pp. 2378-2383 | ||
| 504 | |a Zeisel, Mauron, Watkins, Wurtman, Developmental changes in brain indoles, serum tryptophan and other serum neutral amino acids in the rat (1981) Dev. Brain Res., 1, pp. 551-564 | ||
| 520 | 3 | |a The release of luteinizing hormone (LH) evoked by exogenous serotonin (5 mg/kg, i.p.) was measured at different developmental ages in the female rat. Since LH response to serotonin is modulated by estrogen, moxestrol, a synthetic compound which does not bind to α-fetoprotein, was administered 48 h before serotonin or saline injections. Serotonin was ineffective in releasing LH in 5-day females pretreated with moxestrol; the response increased abruptly at 12 and 18 days and from then onwards decreased gradually. This is in clear contrast to the development of the serotonin-induced prolactin release, which is absent in the first postnatal week, becomes evident on day 12 and increases gradually as the rat approaches puberty. In a second group of experiments, the ontogenesis of hypothalamic-preoptic suprachiasmatic [3H]serotonin binding was studied in 5-, 16-, 27- and 37-day-old female rats. A specific serotonergic binding site could be quantified at 5 days (Bmax 4.31 : 1.89 fmol/μg DNA; Kd:2.74 : 1.17 nM). A gradual increase of both, Bmax and Kd was observed as the animal matured: the number of binding sites almost doubled from day 16 to day 27, and increased even further by 37 days (Bmax 24.21 : 5.16 fmol/μg DNA). These data indicate: (a) a specific [3H]serotonin binding site in hypothalamic-preoptic suprachiasmatic area is present in the first postnatal week of the female rat: (b) Bmax and Kd values increase from 5 to 37 days of age; (c) serotonin-induced LH release in moxestrol-pretreated females is maximal in postnatal weeks 2-3; and (d) ontogenesis of serotonin binding sites in the hypothalamus is in correlation to prolactin, but not to LH release evoked by exogenously administered indoleamine. © 1986. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: This work was supported by the Consejo Nacional de Investigaciones Cientfficas y Tecnicas and the Universidad de Buenos Aires, Argentina. | ||
| 593 | |a Instituto de Biología y Medicina Experimental, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a HYPOTHALAMIC-PREOPTIC SUPRACHIASMATIC AREA |
| 690 | 1 | 0 | |a LUTEINIZING HORMONE (LH) |
| 690 | 1 | 0 | |a MOXESTROL |
| 690 | 1 | 0 | |a ONTOGENESIS |
| 690 | 1 | 0 | |a PROLACTIN |
| 690 | 1 | 0 | |a [3H]SEROTONIN BINDING |
| 690 | 1 | 0 | |a INDOLEAMINE |
| 690 | 1 | 0 | |a MOXESTROL |
| 690 | 1 | 0 | |a PROLACTIN |
| 690 | 1 | 0 | |a RADIOISOTOPE |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a AUTONOMIC NERVOUS SYSTEM |
| 690 | 1 | 0 | |a AUTOPSY |
| 690 | 1 | 0 | |a CENTRAL NERVOUS SYSTEM |
| 690 | 1 | 0 | |a DRUG BINDING |
| 690 | 1 | 0 | |a DRUG RECEPTOR BINDING |
| 690 | 1 | 0 | |a ETIOLOGY |
| 690 | 1 | 0 | |a HYPOTHALAMUS |
| 690 | 1 | 0 | |a INTRAPERITONEAL DRUG ADMINISTRATION |
| 690 | 1 | 0 | |a LUTEINIZING HORMONE RELEASE |
| 690 | 1 | 0 | |a METHODOLOGY |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PHARMACOKINETICS |
| 690 | 1 | 0 | |a PREOPTIC AREA |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a SEROTONIN H 3 |
| 690 | 1 | 0 | |a SUBCUTANEOUS DRUG ADMINISTRATION |
| 690 | 1 | 0 | |a SUPRACHIASMATIC NUCLEUS |
| 700 | 1 | |a Libertun, C. | |
| 773 | 0 | |d 1986 |g v. 25 |h pp. 111-116 |k n. 1 |p Dev. Brain Res. |x 01653806 |w (AR-BaUEN)CENRE-4396 |t Developmental Brain Research | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/0165-3806(86)90157-4 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_01653806_v25_n1_p111_BecuVillalobos |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01653806_v25_n1_p111_BecuVillalobos |y Registro en la Biblioteca Digital |
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| 999 | |c 79136 | ||