Alterations in nitric oxide synthase activity and expression in submandibular glands of nod mice

The non-obese diabetic (NOD) mouse model of autoimmune sialadenitis offers the possibility of studying the L-arginine/nitric oxide signaling pathway in salivary glands in basal and neurotransmitter-stimulated conditions and, thus, of analyzing the neural control of the secretory process in the targe...

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Autor principal: Rosignoli, F.
Otros Autores: Goren, N.B, Pérez Leirós, C.
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: Academic Press Inc. 2001
Acceso en línea:Registro en Scopus
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100 1 |a Rosignoli, F. 
245 1 0 |a Alterations in nitric oxide synthase activity and expression in submandibular glands of nod mice 
260 |b Academic Press Inc.  |c 2001 
270 1 0 |m Pérez Leirós, C.; Departamento de Quimica Biologica, Ciudad Universitaria, Pabellón II, 4 piso, (1428) Buenos Aires, Argentina; email: cpleiros@qb.fcen.uba.ar 
506 |2 openaire  |e Política editorial 
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520 3 |a The non-obese diabetic (NOD) mouse model of autoimmune sialadenitis offers the possibility of studying the L-arginine/nitric oxide signaling pathway in salivary glands in basal and neurotransmitter-stimulated conditions and, thus, of analyzing the neural control of the secretory process in the target organ. The purpose of this study was to explore putative alterations in the activity and expression of nitric oxide synthase (NOS) in submandibular glands of NOD mice in relation to parotid glands and unrelated tissues. Here we report that NOD mice with incipient signs of secretory dysfunction presented a marked decrease in basal and vasoactive intestinal peptide (VIP)-stimulated NOS activity and a differential expression of NOS I in submandibular glands compared to control BALB/c mice. Similar alterations in NOS I were found in parotid glands but not in brain or spleen of NOD mice. No differences between NOD and controls appeared in NOS II and NOS III expression in any of the tissues studied. © 2001 Academic Press.  |l eng 
536 |a Detalles de la financiación: Ministerio de Salud de la Nación, MSAL 
536 |a Detalles de la financiación: Fundación Alberto J. Roemmers 
536 |a Detalles de la financiación: This work was supported by Grant “Beca Ramón Carrillo–Arturo Oñativia” (2000) from the Ministerio de Salud of Argentina and Grant 2000–2002 from Fundación Alberto J. Roemmers. We wish to thank Drs. Graciela Lammel and Adela Rosenkranz for helpful advice regarding NOD mice management and Mrs. Micaela Ricca and Marianela Lewicky for their expert technical assistance. 
593 |a Departamento De Química Biológica, Facultad De Ciencias Exactas Y Naturales, Universidad De Buenos Aires-CONICET, Buenos Aires, Argentina 
593 |a Facultad De Ciencias Exactas Y Naturales, Universidad De Buenos Aires-CONICET, Centro De Estudios Farmacológicos Y Botánicos-CONICET, Buenos Aires, Argentina 
690 1 0 |a AUTOIMMUNE SIALADENITIS 
690 1 0 |a NITRIC OXIDE SYNTHASE 
690 1 0 |a NOD 
690 1 0 |a NOS ISOFORMS 
690 1 0 |a SALIVARY GLANDS 
690 1 0 |a VIP 
690 1 0 |a AUTOANTIBODY 
690 1 0 |a NITRIC OXIDE SYNTHASE 
690 1 0 |a ANIMAL EXPERIMENT 
690 1 0 |a ANIMAL MODEL 
690 1 0 |a ARTICLE 
690 1 0 |a AUTOIMMUNITY 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a ENZYME ACTIVITY 
690 1 0 |a FLOW RATE 
690 1 0 |a INFLAMMATORY CELL 
690 1 0 |a LYMPHOCYTE PROLIFERATION 
690 1 0 |a MOUSE 
690 1 0 |a NEUROTRANSMITTER RELEASE 
690 1 0 |a NONHUMAN 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a SALIVATION 
690 1 0 |a SIALOADENITIS 
690 1 0 |a SJOEGREN SYNDROME 
690 1 0 |a SUBMANDIBULAR GLAND 
690 1 0 |a TARGET CELL 
690 1 0 |a TRANSLATION REGULATION 
700 1 |a Goren, N.B. 
700 1 |a Pérez Leirós, C. 
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