Human chagasic IgG interacting with lymphocyte neurotransmitter receptors triggers intracellular signal transduction
It is demonstrated that human IgG in Chagas' disease and the corresponding F(ab)'2 fragment attach to lymphoid cells by specific interaction with β-adrenergic and muscarinic cholinergic receptors. This interaction resulted in the transduction of signals that increased intracellular levels...
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| Autor principal: | |
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| Otros Autores: | , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1990
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| Acceso en línea: | Registro en Scopus Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 03653caa a22007937a 4500 | ||
|---|---|---|---|
| 001 | PAPER-19384 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205044.0 | ||
| 008 | 190411s1990 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0025357211 | |
| 024 | 7 | |2 cas |a Cyclic AMP, 60-92-4; Cyclic GMP, 7665-99-8; Dinoprostone, 363-24-6; Immunoglobulin G; Receptors, Adrenergic, beta; Receptors, Muscarinic | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a FAJOE | ||
| 100 | 1 | |a Sterin-Borda, L. | |
| 245 | 1 | 0 | |a Human chagasic IgG interacting with lymphocyte neurotransmitter receptors triggers intracellular signal transduction |
| 260 | |c 1990 | ||
| 506 | |2 openaire |e Política editorial | ||
| 520 | 3 | |a It is demonstrated that human IgG in Chagas' disease and the corresponding F(ab)'2 fragment attach to lymphoid cells by specific interaction with β-adrenergic and muscarinic cholinergic receptors. This interaction resulted in the transduction of signals that increased intracellular levels of cAMP in enriched T helper cell preparations and cGMP in enriched T suppressor cell preparations. The stimulation of Ts cell muscarinic cholinergic receptors by Chagas IgG or the corresponding F(ab)'2 fraction triggers the release of the immunomodulatory substance PGE2. These results are unified in a theory of immunoregulation and could contribute to the chronic course of Chagas' disease. |l eng | |
| 593 | |a Centro de Estudios Farmacologicos y de Principios Naturales, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Serrano 665, 1414 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ANTINEUROTRANSMITTER IGG |
| 690 | 1 | 0 | |a CAMP |
| 690 | 1 | 0 | |a CGMP |
| 690 | 1 | 0 | |a CHAGAS' DISEASE |
| 690 | 1 | 0 | |a PGE |
| 690 | 1 | 0 | |a T HELPER CELL Β ADRENORECEPTOR |
| 690 | 1 | 0 | |a T SUPPRESSOR CHOLINERGIC RECEPTOR |
| 690 | 1 | 0 | |a CHOLINERGIC RECEPTOR |
| 690 | 1 | 0 | |a CYCLIC AMP |
| 690 | 1 | 0 | |a CYCLIC GMP |
| 690 | 1 | 0 | |a IMMUNOGLOBULIN G |
| 690 | 1 | 0 | |a MUSCARINIC RECEPTOR |
| 690 | 1 | 0 | |a NEUROTRANSMITTER RECEPTOR |
| 690 | 1 | 0 | |a PROSTAGLANDIN E2 |
| 690 | 1 | 0 | |a RADIOISOTOPE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CHAGAS DISEASE |
| 690 | 1 | 0 | |a HELPER CELL |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a IMMUNOREGULATION |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 690 | 1 | 0 | |a SUPPRESSOR CELL |
| 690 | 1 | 0 | |a T LYMPHOCYTE |
| 690 | 1 | 0 | |a BINDING, COMPETITIVE |
| 690 | 1 | 0 | |a CHAGAS DISEASE |
| 690 | 1 | 0 | |a CYCLIC AMP |
| 690 | 1 | 0 | |a CYCLIC GMP |
| 690 | 1 | 0 | |a DINOPROSTONE |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a IMMUNOGLOBULIN G |
| 690 | 1 | 0 | |a RECEPTORS, ADRENERGIC, BETA |
| 690 | 1 | 0 | |a RECEPTORS, MUSCARINIC |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a T-LYMPHOCYTES |
| 690 | 1 | 0 | |a T-LYMPHOCYTES, HELPER-INDUCER |
| 690 | 1 | 0 | |a T-LYMPHOCYTES, SUPPRESSOR-EFFECTOR |
| 700 | 1 | |a Gorelik, G. | |
| 700 | 1 | |a Genaro, A. | |
| 700 | 1 | |a Goin, J.C. | |
| 700 | 1 | |a Borda, E.S. | |
| 773 | 0 | |d 1990 |g v. 4 |h pp. 1661-1667 |k n. 6 |p FASEB J. |x 08926638 |w (AR-BaUEN)CENRE-996 |t FASEB Journal | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025357211&partnerID=40&md5=b5841620d96d010e2a4689e1af71ff5a |y Registro en Scopus |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_08926638_v4_n6_p1661_SterinBorda |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08926638_v4_n6_p1661_SterinBorda |y Registro en la Biblioteca Digital |
| 961 | |a paper_08926638_v4_n6_p1661_SterinBorda |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 80337 | ||