Hormonal regulation of spermatogenesis in the hypophysectomized rat: FSH maintenance of cellular viability during pubertal spermatogenesis
The potential for follicle-stimulating hormone (FSH) to promote germ- cell survival and the cellular sites of FSH action were studied using a gonadally maturing (pubertal), hypophysectomized (Hx) rat model in which residual testosterone (T) activity was blocked by injections of an androgen- receptor...
Guardado en:
| Autor principal: | |
|---|---|
| Otros Autores: | , , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1998
|
| Acceso en línea: | Registro en Scopus Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 15253caa a22015257a 4500 | ||
|---|---|---|---|
| 001 | PAPER-19829 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205112.0 | ||
| 008 | 190411s1998 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0031800536 | |
| 024 | 7 | |2 cas |a Androgen Antagonists; Flutamide, 13311-84-7; Follicle Stimulating Hormone, 9002-68-0; Testosterone, 58-22-0 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JOAND | ||
| 100 | 1 | |a Russell, L.D. | |
| 245 | 1 | 0 | |a Hormonal regulation of spermatogenesis in the hypophysectomized rat: FSH maintenance of cellular viability during pubertal spermatogenesis |
| 260 | |c 1998 | ||
| 270 | 1 | 0 | |m Russell, L.D.; Laboratory of Structural Biology, Department of Physiology, Southern Illinois University, Carbondale, IL 62901-6512, United States |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Arslan, M., Weinbauer, G.F., Schlatt, S., Shahab, M., Nieschlag, E., FSH and testosterone, alone or in combination, initiate testicular growth and increase the number of spermatogonia and Sertoli cells in a juvenile non-human primate (Macaco mulatta) (1993) J Endocrinol, 136, pp. 235-243 | ||
| 504 | |a Awoniyi, C.A., Santulli, R., Chandrasehkar, V., Schanbacher, B.D., Zirkin, B.R., Quantitative restoration of advanced spermatogenic cells in adult male rats made azoospermic by active immunization against luteinizing hormone or gonadotropin-releasing hormone (1989) Endocrinology, 125, pp. 1303-1309 | ||
| 504 | |a Bartlett, J.M., Kerr, J.B., Sharpe, R.M., The effect of selective destruction and regeneration of rat Leydig cells on the intratesticular distribution of testosterone and morphology of the seminiferous epithelium (1986) J Androl, 7, pp. 240-253 | ||
| 504 | |a Blok, L.J., Mackenbach, P., Trapman, J., Themmen, A.P., Brinkmann, A.O., Grootegoed, J.A., Follicle-stimulating hormone regulates androgen receptor mRNA in Sertoli cells (1989) Mol Cell Endocrinol, 63, pp. 267-271 | ||
| 504 | |a Chemes, H.E., Dym, M., Raj, H.G.M., Hormonal regulation of Sertoli cell differentiation (1979) Biol Reprod, 21, pp. 251-262 | ||
| 504 | |a Chemes, H.E., Dym, M., Raj, H.G.M., The role of gonadotropins and testosterone on initiation of spermatogenesis in the immature rat (1979) Biol Reprod, 21, pp. 241-249 | ||
| 504 | |a Clermont, Y., Perey, B., Quantitative study of the cell population of the seminiferous tubules in immature rats (1957) Am J Anat, 100, pp. 241-268 | ||
| 504 | |a Cunningham, G.R., Huckins, C., Persistence of complete spermatogenesis in the presence of low intratesticular concentration of testosterone (1979) Endocrinology, 105, pp. 177-186 | ||
| 504 | |a El Shennawy, A., Gates, R.J., Russell, L.D., Hormonal regulation of spermatogenesis in the hypophysectomized rat: Cell viability after hormonal replacement in adults after intermediate periods of hypophysectomy (1998) J Androl, 19 (3), pp. 320-334 | ||
| 504 | |a França, L.R., Jackson, A., Russell, L.D., Hormone sensitivity of germ cells in Stage XIV and Stage I of the rat spermatogenic cycle (1994) Tissue Cell, 26, pp. 375-383 | ||
| 504 | |a França, L.R., Ye, S.-J., Ying, L., Sandberg, M., Russell, L.D., Morphometry of rat germ cells during spermatogenesis (1995) Anat Rec, 241, pp. 181-204 | ||
| 504 | |a Ghosh, S., Bartke, A., Grasso, P., Reichert, L.E.J., Russell, L.D., Structural manifestations of the rat Sertoli cell to hypophysectomy: A correlative morphometric and endocrine study (1992) Endocrinology, 131, pp. 485-497 | ||
| 504 | |a Ghosh, S., Bartke, A., Grasso, P., Reichert, L.E.J., Russell, L.D., Structural response of the hamster Sertoli cell to hypophysectomy: A correlative morphometric and endocrine study (1992) Anat Rec, 234, pp. 513-529 | ||
| 504 | |a Gorczynska, E., Handelsman, D.J., The role of calcium in follicle-stimulating hormone signal transduction in Sertoli cells (1991) J Biol Chem, 266, pp. 23739-23744 | ||
| 504 | |a Gorczynska, E., Handelsman, D.J., Androgens rapidly increase the cytosolic calcium concentration in Sertoli cells (1995) Endocrinology, 136, pp. 2052-2059 | ||
| 504 | |a Huckins, C., Oakberg, E.F., Morphological and quantitative analysis of spermatogonia in mouse testis using whole mounted seminiferous tubules. I. The normal testis (1978) Anat Rec, 192, pp. 519-528 | ||
| 504 | |a Kerr, J.B., Maddocks, S., Sharpe, R.M., Testosterone and FSH have independent, synergistic and stage-dependent effects upon spermatogenesis in the rat testis (1992) Cell Tissue Res, 268, pp. 179-189 | ||
| 504 | |a Kumar, T.R., Wang, Y., Lu, N., Matzuk, M.M., Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility (1997) Nat Genet, 15, pp. 201-204 | ||
| 504 | |a Matsumoto, A.M., Hormonal control of spermatogenesis (1989) The Testis. 2nd Ed., pp. 181-196. , Burger H, de Kretser DM, eds. New York: Raven Press | ||
| 504 | |a Meachem, S.J., Wreford, N.G., Robertson, D.M., McLaqchlan, R.I., Androgen action on the restoration of spermatogenesis in adult rats: Effects of human chorionic gonadotropin, testosterone and flutamide administration on germ cell number (1997) Int J Androl, 20, pp. 70-79 | ||
| 504 | |a Niklowitz, P., Khan, S., Bergmann, M., Hoffmann, K., Nieschlag, E., Differential effects of follicle-stimulating hormone and luteinizing hormone on Leydig cell function and restoration of spermatogenesis in hypophysectomized and photoinhibited Djungarian hamsters (Phodopus sungorus) (1989) Biol Reprod, 41, pp. 871-880 | ||
| 504 | |a O'Shaughnessy, P.J., Bennett, M.K., Scott, I.S., Charlton, H.M., Effects of FSH on Leydig cell morphology and function in the hypogonadal mouse (1992) J Endocrinol, 135, pp. 517-525 | ||
| 504 | |a Peets, E.A., Henson, M.F., Neri, R., On the mechanism of the anti-androgenic action of flutamide in the rat (1974) Endocrinology, 94, pp. 532-540 | ||
| 504 | |a Raj, H.G.M., Dym, M., The effects of selective withdrawal of FSH or LH on spermatogenesis in the immature rat (1976) Biol Reprod, 14, pp. 489-494 | ||
| 504 | |a Raj, H.G.M., Sairam, M.R., Dym, M., Kotite, N., Frenceh, F.S., Sloan, C., Dy, R.C., Effect of immunization against follicle stimulating hormone on spermatogenesis in the rat and the monkey (1980) Non-Human Primate Models for Study of Human Reproduction, pp. 176-189. , Anad Kumar TC, ed. Basel: S. Karger | ||
| 504 | |a Rulli, S.B., Gonzalez-Calvar, S.I., Campo, S., Calandra, R.S., Effects of two non-steroidal antiandrogens on testicular function in prepubertal rats (1995) J Androl, 16, pp. 225-232 | ||
| 504 | |a Russell, L.D., Alger, L.E., Nequin, L.G., Hormonal control of pubertal spermatogenesis (1987) Endocrinology, 120, pp. 1615-1632 | ||
| 504 | |a Russell, L.D., Clermont, Y., Degeneration of germ cells in normal, hypophysectomized and hormone treated hypophysectomized rats (1977) Anal Rec, 187, pp. 347-366 | ||
| 504 | |a Russell, L.D., Corbin, T.J., Borg, K.E., De França, L.R., Grasso, P., Bartke, A., Recombinant human FSH is capable of exerting a biological effect in the adult hypophysectomized rat by reducing the numbers of degenerating germ cells (1993) Endocrinology, 133, pp. 2062-2070 | ||
| 504 | |a Russell, L.D., Ettlin, R.A., Sinha Hikim, A.P., Clegg, E.D., (1990) Histological and Histopathological Evaluation of the Testis, , Clearwater, Florida: Cache River Press | ||
| 504 | |a Russell, L.D., França, L.R., Building a testis (1995) Tissue Cell, 27, pp. 129-147 | ||
| 504 | |a Russell, L.D., Frank, B., Characterization of rat spermatocytes after plastic embedding (1978) Arch Androl, 1, pp. 15-18 | ||
| 504 | |a Schlatt, S., Weinbauer, G.F., Arslan, M., Nieschlag, E., Appearance of α-smooth muscle actin in peritubular cells of monkey testes is induced by androgens, modulated by follicle-stimulating hormone, and maintained after hormonal withdrawal (1993) J Androl, 14, pp. 340-350 | ||
| 504 | |a Sharpe, R.M., Regulation of spermatogenesis (1994) The Physiology of Reproduction, pp. 1363-1434. , Knobil E, Neill JD, eds. New York: Raven Press | ||
| 504 | |a Sharpe, R.M., Bartlett, J.M., Stimulation of Leydig cell function by a polypeptide present in testicular interstitial fluid (1985) Med Biol, 63, pp. 245-250 | ||
| 504 | |a Singh, J., O'Neill, C., Handelsman, J., Induction of spermatogenesis by androgens in gonadotropin-deficient (hpg) mice (1995) Endocrinology, 136, pp. 5311-5321 | ||
| 504 | |a Sinha Hikim, A.P., Swerdloff, R.S., Temporal and stage-specific effects of recombinant human follicle-stimulating hormone on the maintenance of spermatogenesis in gonadotropin-releasing hormone antagonist-treated rat (1995) Endocrinology, 136, pp. 253-261 | ||
| 504 | |a Skinner, M.K., Sertoli cell-peritubular myoid cell interactions (1993) The Sertoli Cell, pp. 477-483. , Russell LD, Griswold MD, eds. Clearwater, Florida: Cache River Press | ||
| 504 | |a Steinberger, E., Hormonal regulation of the seminiferous tubule function (1975) Curr Top Mol Endocrinol, 2, pp. 337-352 | ||
| 504 | |a Suescun, M.O., Gonzalez, S.I., Chiauzzi, V.A., Calandra, R.S., Effects of induced hypoprolactinemia on testicular function during gonadal maturation in the rat (1985) J Androl, 6, pp. 77-82 | ||
| 504 | |a Teutsch, G., Goubet, F., Battmann, T., Bonfils, A., Bouchoux, F., Cerede, E., Gofflo, D., Philibert, D., Non-steroidal antiandrogens: Synthesis and biological profile of high-affinity ligands for the androgen receptor (1994) J Steroid Biochem Mol Biol, 48, pp. 111-119 | ||
| 504 | |a Verhoeven, G., Cailleau, J., Follicle-stimulating hormone and androgens increase the concentration of the androgen receptor in Sertoli cells (1988) Endocrinology, 122, pp. 1541-1550 | ||
| 504 | |a Vihko, K.K., Lapolt, P.S., Dargan, C., Nishimori, K., Hsueh, A.J.W., Stimulatory effect of recombinant FSH on Leydig cell function and spermatogenesis in vivo (1991) Endocrinology, 129, pp. 1926-1932 | ||
| 504 | |a Zirkin, B.R., Awoniyi, C., Griswold, M.D., Russell, L.D., Sharpe, R.M., Is FSH required for adult spermatogenesis? (1994) J Androl, 15, pp. 273-276 | ||
| 504 | |a Zirkin, B.R., Santulli, R., Awoniyi, C., Ewing, L.L., Maintenance of advance spermatogenic cells in the adult rat testis: Quantitative relationship to testosterone concentration within the testis (1989) Endocrinology, 124, pp. 3043-3049 | ||
| 520 | 3 | |a The potential for follicle-stimulating hormone (FSH) to promote germ- cell survival and the cellular sites of FSH action were studied using a gonadally maturing (pubertal), hypophysectomized (Hx) rat model in which residual testosterone (T) activity was blocked by injections of an androgen- receptor antagonist, flutamide. Recombinant human FSH was given to androgen- deprived and androgen-blocked male rats at 27 days of age to determine maintenance of individual germ-cell types at 35 days of age. Follicle- stimulating hormone significantly increased testis weights and tubular diameters as compared with Hx and Hx-flutamide controls, although testis weights in FSH-treated animals were significantly lower than in pituitary- intact animals. Morphometric assays to determine ratios of germ cells to Sertoli cells and to determine the number of germ cells present per hour of development showed that the population of type A spermatogonia in the early stages of the cycle was not responsive to FSH. Follicle-stimulating hormone had a marked ability to maintain cell viability in the rapid, successive divisions that begin in the latter part of the cycle and that continue through the next cycle (i.e., from type A1 to A4 and from intermediate spermatogonia to type B spermatogonia to preleptotene spermatocytes to leptotene/zygotene spermatocytes to young pachytene spermatocytes). The data also suggest T responsiveness of these cell types since the Hx-FSH-flutamide group showed lower cell viability at the aforementioned steps when compared with the Hx-FSH group. Too few cell types were present at subsequent phases of spermatogenesis to allow a sensitive determination of FSH activity in the maintenance of cell viability. The data show the potential of FSH in the absence or relative absence of T activity to maintain cell viability. These data support the concept of overlapping and synergistic (or additive) effects of T and FSH in the immature rat and identify the cellular sites of FSH action. |l eng | |
| 593 | |a Department of Physiology, Southern Illinois University, School of Medicine, Carbondale, IL, United States | ||
| 593 | |a Laboratory of Structural Biology, Department of Physiology, Southern Illinois University, Carbondale, IL 62901-6512, United States | ||
| 593 | |a Dept. of Pharmacology and Toxicology, Univ. of N. Dakota Sch. of Medicine, Health Science Center, 501 North Columbia Road, Grand Forks, ND 58202-9037, United States | ||
| 593 | |a Inst. de Biol. y Med. Experimental, Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 593 | |a Coop. Wildlife Research Laboratory, Department of Zoology, Southern Illinois University, Carbondale, IL 62901-6504, United States | ||
| 690 | 1 | 0 | |a CELL VIABILITY |
| 690 | 1 | 0 | |a HYPOHYSECTOMY |
| 690 | 1 | 0 | |a TESTIS |
| 690 | 1 | 0 | |a TESTOSTERONE |
| 690 | 1 | 0 | |a ANDROGEN RECEPTOR |
| 690 | 1 | 0 | |a FLUTAMIDE |
| 690 | 1 | 0 | |a FOLLITROPIN |
| 690 | 1 | 0 | |a RECOMBINANT FOLLITROPIN |
| 690 | 1 | 0 | |a TESTOSTERONE |
| 690 | 1 | 0 | |a ADOLESCENT |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL VIABILITY |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a GERM CELL |
| 690 | 1 | 0 | |a HORMONAL REGULATION |
| 690 | 1 | 0 | |a HORMONE ACTION |
| 690 | 1 | 0 | |a HYPOPHYSECTOMY |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PUBERTY |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a SEMINIFEROUS TUBULE |
| 690 | 1 | 0 | |a SERTOLI CELL |
| 690 | 1 | 0 | |a SPERMATOCYTE |
| 690 | 1 | 0 | |a SPERMATOGENESIS |
| 690 | 1 | 0 | |a TESTIS WEIGHT |
| 690 | 1 | 0 | |a ANDROGEN ANTAGONISTS |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BODY WEIGHT |
| 690 | 1 | 0 | |a FLUTAMIDE |
| 690 | 1 | 0 | |a FOLLICLE STIMULATING HORMONE |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a HYPOPHYSECTOMY |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MODELS, BIOLOGICAL |
| 690 | 1 | 0 | |a ORGAN SIZE |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a SEMINIFEROUS TUBULES |
| 690 | 1 | 0 | |a SEXUAL MATURATION |
| 690 | 1 | 0 | |a SPERM COUNT |
| 690 | 1 | 0 | |a SPERMATOGENESIS |
| 690 | 1 | 0 | |a TESTIS |
| 690 | 1 | 0 | |a TESTOSTERONE |
| 700 | 1 | |a Kershaw, M. | |
| 700 | 1 | |a Borg, K.E. | |
| 700 | 1 | |a El Shennawy, A. | |
| 700 | 1 | |a Rulli, S.S. | |
| 700 | 1 | |a Gates, R.J. | |
| 700 | 1 | |a Calandra, R.S. | |
| 773 | 0 | |d 1998 |g v. 19 |h pp. 308-319 |k n. 3 |p J. Androl. |x 01963635 |t Journal of Andrology | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031800536&partnerID=40&md5=78329608c853b4c929dd973d2d13639a |y Registro en Scopus |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_01963635_v19_n3_p308_Russell |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01963635_v19_n3_p308_Russell |y Registro en la Biblioteca Digital |
| 961 | |a paper_01963635_v19_n3_p308_Russell |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 80782 | ||