On the promoting action of tamoxifen in a model of hepatocarcinogenesis induced by p-dimethylaminoazobenzene in CF1 mice
Background and aims: Tamoxifen (TMX) has proven to be an effective palliative treatment for advanced breast cancer with low reported incidence of side effects. TMX has been demonstrated to be an initiator and/or a promoter in the rat model of hepatocarcinogenesis. To document the long-term effect of...
Guardado en:
| Autor principal: | |
|---|---|
| Otros Autores: | , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
2001
|
| Materias: | |
| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 13679caa a22014657a 4500 | ||
|---|---|---|---|
| 001 | PAPER-2014 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203120.0 | ||
| 008 | 190411s2001 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0034995019 | |
| 024 | 7 | |2 cas |a 5-Aminolevulinate Synthetase, EC 2.3.1.37; Carcinogens; Catalase, EC 1.11.1.6; Cytochrome P-450 Enzyme System, 9035-51-2; Glutathione Transferase, EC 2.5.1.18; Heme Oxygenase (Decyclizing), EC 1.14.99.3; p-Dimethylaminoazobenzene, 60-11-7; Superoxide Dismutase, EC 1.15.1.1; Tamoxifen, 10540-29-1; Thiobarbituric Acid Reactive Substances | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a IJBBF | ||
| 100 | 1 | |a Caballero, F. | |
| 245 | 1 | 3 | |a On the promoting action of tamoxifen in a model of hepatocarcinogenesis induced by p-dimethylaminoazobenzene in CF1 mice |
| 260 | |c 2001 | ||
| 270 | 1 | 0 | |m Batlle, A.Viamonte 1881 10o 'A', C1056ABA-Buenos Aires, Argentina; email: battle@mail.retina.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Systemic treatment of early breast cancer by hormonal, cytotoxic or immune therapy (1992) Lancet, 339, pp. 1-15 | ||
| 504 | |a Fisher, B., Redmond, C., New perspective on cancer of the contralateral breast: A marker for assessing tamoxifen as preventive agent (1991) J. Natl. Cancer Inst., 83, pp. 1278-1280 | ||
| 504 | |a Tucker, M.J., Adam, H.K., Patterson, J.S., Tamoxifen (1984) Safety Testing of New Drugs. Laboratory Predictions and Clinical Performance, pp. 125-161. , D.R. Laurence, A.E.M. McLean, M. Weatherall (Eds.), Academic Press, London | ||
| 504 | |a Williams, G.M., Iatropoulos, M.J., Hard, G.C., Long-term prophylactic use of tamoxifen: Is it safe? (1992) Eur. J. Cancer Prevent., 1, pp. 386-387 | ||
| 504 | |a Hirsimäki, P., Hirsimäki, Y., Nieminen, L., Payne, B., Tamoxifen induces hepatocellular carcinoma in rat liver: A one year study with two carcinogens (1993) Arch. Toxicol., 67, pp. 49-54 | ||
| 504 | |a Wogan, G., Review of the toxicology of tamoxifen (1997) Semin. Oncol., 24, pp. S187-S197 | ||
| 504 | |a White, I.N.H., De Matteis, F., Davies, A., Smith, L.L., Crofton-Sleigh, C., Venitt, S., Hewer, A., Phillips, D.H., Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 and C57B1/6 mice and in human MCL-5 cells (1992) Carcinogenesis, 13, pp. 2197-2203 | ||
| 504 | |a Carthew, P., Nartin, E.A., White, I.N., De Matteis, F., Edwards, R.E., Dorman, B.M., Heydon, R.T., Smith, L.L., Tamoxifen induces short-term cumulative DNA damage and liver tumors in rats: Promotion by phenobarbital (1995) Cancer Res., 55, pp. 544-547 | ||
| 504 | |a Pathak, D.N., Badell, W.Y., DNA adducts formation by tamoxifen with rat and human liver microsomal activating systems (1994) Carcinogenesis, 15, pp. 529-532 | ||
| 504 | |a Dragan, Y., Fahey, S., Nuwaysir, E., Sattler, C., Babcock, K., Vaughan, J., McCague, R., Pitot, H., The effect of tamoxifen and two of its non-isomerizable fixed-ring analogues on multistage rat hepatocarcinogenesis (1996) Carcinogenesis, 17, pp. 585-594 | ||
| 504 | |a Smith, L., White, I., Chemoprevention of breast cancer by tamoxifen: Risks and opportunities (1995) Toxicol. Lett., 82, pp. 181-186 | ||
| 504 | |a Ghia, M., Mereto, E., Induction and promotion of gamma-glutamyltranspeptidase-positive foci in the liver of female rats treated with ethinyl estradiol, clomiphene, tamoxifen and their associations (1989) Cancer Lett., 46, pp. 195-202 | ||
| 504 | |a Dragan, Y.P., Fahey, S., Street, K., Vaughan, J., Jordan, V.C., Pitot, H.C., Studies of tamoxifen as a promoter of hepatocarcinogenesis in female Fischer F344 rats (1994) Breast Cancer Res. Treat., 31, pp. 11-25 | ||
| 504 | |a Gerez, E., Vazquez, E., Caballero, F., Polo, C., Batlle, A., Altered heme pathway regulation and drug metabolizing enzyme system in a mouse model of hepatocarcinogenesis. Effect of veronal (1997) Gen. Pharmacol., 29, pp. 569-573 | ||
| 504 | |a Vazquez, E., Gerez, E., Caballero, F., Polo, C., Batlle, A., Drug metabolizing enzyme system and heme pathway in hepatocarcinogenesis (1999) Cancer Biochem. Biophys., 17, pp. 25-34 | ||
| 504 | |a Gerez, E., Caballero, F., Vazquez, E., Polo, C., Batlle, A., Hepatic enzymatic metabolism alteration and oxidative stress during the onset of carcinogenesis: Protective role of alpha tocopherol (1998) Eur. J. Cancer Prev., 7, pp. 69-76 | ||
| 504 | |a Marver, H., Tschudy, D., Perlroth, M., Collins, A., δ-aminolevulinic acid synthetase. I. Studies in liver homogenates (1966) J. Biol. Chem., 241, pp. 2803-2809 | ||
| 504 | |a Yoshida, T., Kikuchi, G., Purification and properties of heme oxygenase from pig spleen microsomes (1978) J. Biol. Chem., 253, pp. 4224-4229 | ||
| 504 | |a Omura, T., Sato, R., The carbon monoxide binding pigment of liver microsomes (1964) J. Biol. Chem., 239, pp. 2370-2378 | ||
| 504 | |a Habig, W., Pabst, M., Jakoby, W., Glutathione S-transferases. The first enzymatic step in mercapturic acid formation (1974) J. Biol. Chem., 249, pp. 7130-7139 | ||
| 504 | |a Chance, B., Maehly, A., Assay of catalases and peroxidases (1955) Methods in Enzymology, 2, pp. 764-768. , S.P. Colowick, N.O. Kaplan (Eds.), Academic Press, New York | ||
| 504 | |a Paoletti, F., Aldinucci, D., Mocall, A., Caparrini, A., A sensitive spectrophotometric method for the determination of superoxide dismutase activity in tissue extracts (1986) Anal. Biochem., 154, pp. 536-541 | ||
| 504 | |a Niehaus, W., Samuelson, B., Formation of malondialdehyde from phospholipids arachidonate during microsomal lipid peroxidation (1968) Eur. J. Biochem., 6, pp. 126-130 | ||
| 504 | |a Lowry, O., Rosebrough, N., Farr, A., Randall, R., Protein measurement with the Folin-phenol reagent (1954) J. Biol. Chem., 193, pp. 265-275 | ||
| 504 | |a Jordan, V.C., Long-term tamoxifen therapy to control or to prevent breast cancer: Laboratory concept to clinical trial (1988) Hormones, Cell Biology and Cancer: Perspectives and Potentials, pp. 105-123. , W.D. Hankins (Ed.), Alan R. Liss, New York | ||
| 504 | |a Kim, D., Han, B., Ahn, B., Lee, K., Kang, J., Tsuda, H., Promotion potential of tamoxifen on hepatocarcinogenesis in female SD or F344 rats initiated with diethylnitrosamine (1996) Cancer Lett., 104, pp. 13-19 | ||
| 504 | |a White, I.N.H., Davies, A., Smith, L.L., Dawson, S., De Matteis, F., Induction of CYP2B1 and 3A1 and associated monooxygenase activities by tamoxifen and certain analogues in the liver of female rats and mice (1993) Biochem. Pharmacol., 45, pp. 21-30 | ||
| 504 | |a Nuwaysir, E.F., Daggett, D.A., Jordan, V.C., Pitot, H.C., Phase II enzyme expression in rat liver in response to the antiestrogen tamoxifen (1996) Cancer Res., 56, pp. 3704-3710 | ||
| 504 | |a Lim, C.K., Yuan, Z.K., Lamb, J.H., White, I.N.H., De Matteis, F., Smith, L.L., A comparative study of tamoxifen metabolism in female rat, mouse and human liver microsomes (1994) Carcinogenesis, 15, pp. 589-593 | ||
| 504 | |a Pigeolet, E., Carbisier, P., Houbion, A., Lambert, D., Michiels, C., Raes, M., Zachary, M., Remacle, J., Glutathione peroxidase, superoxide dismutase, and catalase inactivation by peroxides and oxygen derived free radicals (1990) Mech. Ageing Dev., 51, pp. 283-297 | ||
| 504 | |a Greaves, P., Goonetilleke, R., Nunn, G., Topham, J., Orton, T., Two-year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats (1993) Cancer Res., 53, pp. 3919-3924 | ||
| 504 | |a Williams, G.M., Iatropoulos, M.J., Karlsson, S., Initiating activity of anti-estrogen tamoxifen but not toremifene in rat liver (1997) Carcinogenesis, 2, pp. 1111-1117 | ||
| 520 | 3 | |a Background and aims: Tamoxifen (TMX) has proven to be an effective palliative treatment for advanced breast cancer with low reported incidence of side effects. TMX has been demonstrated to be an initiator and/or a promoter in the rat model of hepatocarcinogenesis. To document the long-term effect of TMX in mice treated with p-dimethylaminoazobenzene (DAB), we have investigated the time response action of these drugs on different biochemical parameters. Methods: A group of animals was placed on dietary DAB (0.5%, w/w) during a period of 28 weeks. Control animals received a standard laboratory diet. Two other groups of non-treated and DAB-treated animals received TMX citrate (0.025%, w/w) in the diet since day 20. Results: The activities of the enzymes involved in heme synthesis and degradation as evaluated in the DAB group was not further affected by TMX. DAB and/or TMX treatment significantly increased the content of total cytochrome P450 and also the activity of glutathione S-transferase indicating liver damage. In all treated groups oxidative stress and an adaptive response of the natural defense system (catalase and superoxide dismutase) were demonstrated. Histological and morphological studies revealed liver cell hyperplasia in DAB treated group; however, only in the DAB+TMX group solid, trabecular and acinar hepatocellular carcinoma was confirmed at the end of the experimental trial. Conclusion: We have demonstrated that TMX produced changes in hepatic enzyme activities which may be relevant for the metabolism and disposition of this and/or other drugs. Because liver tumors could be initiated and promoted by several agents which need to be activated, the possible hazard of TMX should be considered. This study reports that long-term treatment with TMX enhances hepatocarcinogenesis induced by DAB. The widespread use of TMX as an anticancer agent adds to the significance of this study. © 2001 Published by Elsevier Science Ltd. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Agency for Science, Technology and Research | ||
| 536 | |a Detalles de la financiación: Association for International Cancer Research, AICR | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: We are very grateful to B. Corvalan and the staff of the Department of Pathology of Dr Bernardo Houssay Hospital for valuable technical assistance during this study. A. Batlle and E. Vazquez are members of the Career of Scientific Researcher at the Argentine National Research Council (CONICET). F. Caballero and E. Gerez hold the post of Research Assistant at the CONICET. N. Falcoff is head of the Department of Pathology at the Hospital ‘Dr Bernardo Houssay’, Vicente López. This work has been supported by grants from CONICET; the University of Buenos Aires, Argentina; AICR, UK; and the Science and Technology Argentine Agency. | ||
| 593 | |a Centro De Investigaciones Sobre Porfirinas Y Porfirias (CIPYP) (CONICET-FCENUBA), Ciudad Universitaria, Pabellón II, 2do piso, 1428 Buenos Aires, Argentina | ||
| 593 | |a Department of Pathology, Hospital 'Dr Bernardo Houssay', Vicente López, Buenos Aires, Argentina | ||
| 593 | |a Viamonte 1881 10o 'A', C1056ABA-Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a CYTOCHROME P450 |
| 690 | 1 | 0 | |a HEPATOCARCINOGENESIS |
| 690 | 1 | 0 | |a OXIDATIVE STRESS |
| 690 | 1 | 0 | |a P-DIMETHYLAMINOAZOBENZENE |
| 690 | 1 | 0 | |a TAMOXIFEN |
| 690 | 1 | 0 | |a 4 DIMETHYLAMINOAZOBENZENE |
| 690 | 1 | 0 | |a ANTINEOPLASTIC AGENT |
| 690 | 1 | 0 | |a CATALASE |
| 690 | 1 | 0 | |a CYTOCHROME P450 |
| 690 | 1 | 0 | |a GLUTATHIONE TRANSFERASE |
| 690 | 1 | 0 | |a LIVER ENZYME |
| 690 | 1 | 0 | |a SUPEROXIDE DISMUTASE |
| 690 | 1 | 0 | |a TAMOXIFEN |
| 690 | 1 | 0 | |a TAMOXIFEN CITRATE |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DEGRADATION |
| 690 | 1 | 0 | |a DIET |
| 690 | 1 | 0 | |a ENZYME ACTIVITY |
| 690 | 1 | 0 | |a HEME SYNTHESIS |
| 690 | 1 | 0 | |a LIVER CARCINOGENESIS |
| 690 | 1 | 0 | |a LIVER CELL CARCINOMA |
| 690 | 1 | 0 | |a LIVER INJURY |
| 690 | 1 | 0 | |a LIVER TUMOR |
| 690 | 1 | 0 | |a LONG TERM CARE |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OXIDATIVE STRESS |
| 690 | 1 | 0 | |a RESPONSE TIME |
| 690 | 1 | 0 | |a 5-AMINOLEVULINATE SYNTHETASE |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BODY WEIGHT |
| 690 | 1 | 0 | |a CARCINOGENS |
| 690 | 1 | 0 | |a CATALASE |
| 690 | 1 | 0 | |a CYTOCHROME P-450 ENZYME SYSTEM |
| 690 | 1 | 0 | |a GLUTATHIONE TRANSFERASE |
| 690 | 1 | 0 | |a HEME OXYGENASE (DECYCLIZING) |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a LIVER NEOPLASMS, EXPERIMENTAL |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a ORGAN SIZE |
| 690 | 1 | 0 | |a P-DIMETHYLAMINOAZOBENZENE |
| 690 | 1 | 0 | |a SUPEROXIDE DISMUTASE |
| 690 | 1 | 0 | |a TAMOXIFEN |
| 690 | 1 | 0 | |a THIOBARBITURIC ACID REACTIVE SUBSTANCES |
| 690 | 1 | 0 | |a TIME FACTORS |
| 690 | 1 | 0 | |a ANIMALIA |
| 651 | 4 | |a LIVER HYPERPLASIA | |
| 700 | 1 | |a Gerez, E. | |
| 700 | 1 | |a Oliveri, L. | |
| 700 | 1 | |a Falcoff, N. | |
| 700 | 1 | |a Batlle, A. | |
| 700 | 1 | |a Vazquez, E. | |
| 773 | 0 | |d 2001 |g v. 33 |h pp. 681-690 |k n. 7 |p Int. J. Biochem. Cell Biol. |x 13572725 |w (AR-BaUEN)CENRE-5218 |t International Journal of Biochemistry and Cell Biology | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034995019&doi=10.1016%2fS1357-2725%2801%2900056-5&partnerID=40&md5=2d2d5023d71bef055f0adec01d615d0b |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/S1357-2725(01)00056-5 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_13572725_v33_n7_p681_Caballero |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13572725_v33_n7_p681_Caballero |y Registro en la Biblioteca Digital |
| 961 | |a paper_13572725_v33_n7_p681_Caballero |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 62967 | ||