Ornithine decarboxylase activity and polyamine levels in the epididymis of prepubertal rat after antiandrogen administration
The antiandrogens flutamide and casodex have been administered subcutaneously (vehicle, 1, 5, or 10 mg per day) to prepubertal male rats for 10 days. A significant change of epididymal weight has been observed after both treatments, from the lowest dose used. Epididymal dihydrotestosterone concentra...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
Taylor and Francis Ltd.
1997
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 09501caa a22010337a 4500 | ||
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| 001 | PAPER-20186 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205134.0 | ||
| 008 | 190411s1997 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-79961204816 | |
| 024 | 7 | |2 cas |a androstanolone, 521-18-6; bicalutamide, 90357-06-5; flutamide, 13311-84-7; ornithine decarboxylase, 9024-60-6; putrescine, 110-60-1, 333-93-7; spermidine, 124-20-9, 334-50-9; spermine, 306-67-2, 71-44-3 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a ARAND | ||
| 100 | 1 | |a Rulli, S.B. | |
| 245 | 1 | 0 | |a Ornithine decarboxylase activity and polyamine levels in the epididymis of prepubertal rat after antiandrogen administration |
| 260 | |b Taylor and Francis Ltd. |c 1997 | ||
| 270 | 1 | 0 | |m Rulli, S.B.; Laboratorio de Esteroides, Inst. de Biologia y Medicina Exp., Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Boyle, G.W., McKillop, D., Phillips, P.J., Harding, J.R., Pickford, R., McCormick, A.D., Metabolism of Casodex in laboratory animals (1993) Xenobiotica, 23, pp. 781-798. , England | ||
| 504 | |a Brooks, D.E., Metabolic activity in the epididymis and its regulation by androgens (1981) Physiol Rev, 61, pp. 515-555 | ||
| 504 | |a Calandra, R.S., Podestá, E.J., Rivarola, M.A., Blaquier, J.A., Tissue androgens and androphilic proteins in rat epididymis during sexual development (1974) Steroids, 24, pp. 507-518 | ||
| 504 | |a Canellakis, Z.N., Marsh, L.L., Bondy, P.K., Polyamines and their derivatives as modulators in growth and differentiation (1989) Yale J Biol Med, 62, pp. 481-491 | ||
| 504 | |a De Larminat, M.A., Cuasnicú, P.S., Blaquier, J.A., The in vitro metabolism of androgens in rat epididymis during sexual development (1980) J Steroid Biochem, 13, pp. 1207-1213 | ||
| 504 | |a De Larminat, M.A., Cuasnicú, P.S., Blaquier, J.A., Changes in trophic and functional parameters of the rat epididymis during sexual maturation (1981) Biol Reprod, 25, pp. 813-819 | ||
| 504 | |a De Las Heras, M.A., Calandra, R.S., Androgen-dependence of ornithine decarboxylase in the rat epididymis (1987) J Reprod Fertil, 79, pp. 9-14 | ||
| 504 | |a De Las Heras, M.A., Calandra, R.S., S-Adenosyl-L-methionine decarboxylase activity in the rat epididymis: Ontogeny and androgenic control (1991) J Androl, 12, pp. 209-213 | ||
| 504 | |a De Las Heras, M.A., Suescun, M.O., Calandra, R.S., Ornithine decarboxylase activity as a marker of androgen and antiandrogen action in the rat epididymis (1988) J Reprod Fertil, 83, pp. 177-183 | ||
| 504 | |a De Las Heras, M.A., Gonzalez, S.I., Calandra, R.S., Androgenic control of polyamines concentrations in rat epididymis (1992) J Reprod Fertil, 96, pp. 323-330 | ||
| 504 | |a Furr, B.J.A., Valcaccia, B., Curry, B., Woodburn, J.R., Chesterson, C., ICI 176,334: A novel non-steroidal, peripherally selective antiandrogen (1987) J Endocrinol, 113, pp. R7-R9 | ||
| 504 | |a Hamilton, D.W., Structure and function of the epithelium lining the ductuli efferentes, ductus epididymidis and ductus deferens in the rat (1975) Handbook of Physiology, 5, pp. 259-301. , Hamilton DW, Greep RO, eds. Washington, DC: American Physiological Society | ||
| 504 | |a Jiang, F.X., Temple-Smith, P., Wreford, N.G., Postnatal differentiation and development of the rat epididymis: A stereological study (1994) Anat Rec, 238, pp. 191-198 | ||
| 504 | |a Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurement with the Folin phenol reagent (1951) J Biol Chem, 193, pp. 265-275 | ||
| 504 | |a Orgebin-Crist, M.C., Olson, G.E., Danzo, B.J., Factors influencing maturation of spermatozoa in the epididymis (1981) Intragonadal Regulation of Reproduction, pp. 393-417. , Franchimont P, Channing CP, eds. New York: Academic | ||
| 504 | |a Pegg, A.E., Recent advances in the biochemistry of polyamines in eukaryotes (1986) Biochem J, 234, pp. 249-262 | ||
| 504 | |a Pujol, A., Bayard, F., Louvet, J.P., Boulard, C., Testosterone and dihydrotestosterone concentrations in plasma, epididymal tissues and seminal fluid of adult rats (1976) Endocrinology, 98, pp. 111-113 | ||
| 504 | |a Robaire, B., Ewing, L.L., Zirkin, B.R., Iray, D.C., Steroid delta4-5α-reductase and 3α-hydroxysteroid dehydrogenase in the rat epididymis (1977) Endocrinology, 101, pp. 1379-1390 | ||
| 504 | |a Rulli, S.B., Gonzalez-Calvar, S.I., Campo, S., Calandra, R.S., Effects of two non-steroidal antiandrogens on the testicular function in prepubertal rats (1995) J Androl, 16, pp. 225-232 | ||
| 504 | |a Russell, D.H., Ornithine decarboxylase: A key regulatory enzyme in normal and neoplastic growth (1985) Drug Metab Rev, 16, pp. 1-88 | ||
| 504 | |a Scalabrino, G., Lorenzini, E.C., Ferioli, M.E., Review: Polyamines and mammalian hormones. Part I: Biosynthesis, interconversion and hormone effects (1991) Mol Cell Endocrinol, 77, pp. 1-35 | ||
| 504 | |a Seiler, N., Thin-layer chromatography and thin-layer electrophoresis by polyamines and their derivatives (1983) Methods Enzymol, 94, pp. 3-9 | ||
| 504 | |a Setty, B.S., Jehan, Q., Functional maturation of the epididymis in the rat (1977) J Reprod Fertil, 49, pp. 317-322 | ||
| 504 | |a Suescun, M.O., Gonzalez, S.I., Chiauzzi, V.A., Calandra, R.S., Effects of induced hypoprolactinemia on testicular function during gonadal maturation in the rat (1985) J Androl, 6, pp. 77-82 | ||
| 504 | |a Tabor, C.W., Tabor, H., Polyamines (1984) Annu Rev Biochem, 53, pp. 749-790 | ||
| 504 | |a Tremblay, D., Dupront, A., Meyer, B.H., Pottier, J., The kinetics of antiandrogens in humans (1987) Prostate Cancer, Part A: Research, Endocrine Treatment and Histopathology, pp. 341-350. , Murphy GP, Khoury S, Kuss R, et al, eds. New York: Liss | ||
| 504 | |a Viguer, R.S., Robaire, B., Differential regulation of steady state 4-ene-steroid 5α-reductase messenger ribonucleic acid levels along the rat epididymis (1991) Endocrinology, 128, pp. 2407-2414 | ||
| 520 | 3 | |a The antiandrogens flutamide and casodex have been administered subcutaneously (vehicle, 1, 5, or 10 mg per day) to prepubertal male rats for 10 days. A significant change of epididymal weight has been observed after both treatments, from the lowest dose used. Epididymal dihydrotestosterone concentrations were significantly increased in flutamide- or casodex-treated rats, while epididymal 3α-androstanediol concentrations were affected only after flutamide administration, suggesting a differential effect on androgen metabolism between both antiandrogens. Ornithine decarboxylase (ODC) activity was significantly decreased by flutamide, and to a lesser extent by casodex. Antiandrogen administration resulted in a significant decrease in epididymal content of the polyamines putrescine, spermidine, and spermine. A slight but significant decrease in putrescine and spermidine concentrations, but not in spermine, was observed after flutamide treatment. However, casodex had no effects on polyamines levels. A decrease in putrescine concentration was detected only when ODC activity fell to rather low levels. Interference of the antiandrogens with the biological action of androgens on ODC activity was clearly seen in immature male rats. Therefore, both epididymal growth and differentiation, in correlation to ODC activity, would be severely affected at an early period of sexual development, such as prepuberty. |l eng | |
| 593 | |a Inst. de Biol. y Med. Experimental, Buenos Aires, Argentina | ||
| 593 | |a Facultad de Medicina, UBA, Buenos Aires, Argentina | ||
| 593 | |a Cátedra de Endocrinologia, Facultad de Ciencias Exactas, UNLP, La Plata, Argentina | ||
| 593 | |a Laboratorio de Esteroides, Inst. de Biol. y Med. Experimental, Vuelta de Obligado 2490, (1428), Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a CASODEX |
| 690 | 1 | 0 | |a EPIDIDYMIS |
| 690 | 1 | 0 | |a FLUTAMIDE |
| 690 | 1 | 0 | |a ORNITHINE DECARBOXYLASE |
| 690 | 1 | 0 | |a POLYAMINES |
| 690 | 1 | 0 | |a ANDROGEN |
| 690 | 1 | 0 | |a ANDROSTANOLONE |
| 690 | 1 | 0 | |a ANTIANDROGEN |
| 690 | 1 | 0 | |a BICALUTAMIDE |
| 690 | 1 | 0 | |a FLUTAMIDE |
| 690 | 1 | 0 | |a ORNITHINE DECARBOXYLASE |
| 690 | 1 | 0 | |a POLYAMINE |
| 690 | 1 | 0 | |a PUTRESCINE |
| 690 | 1 | 0 | |a SPERMIDINE |
| 690 | 1 | 0 | |a SPERMINE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DEVELOPMENT |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a ENZYME ACTIVITY |
| 690 | 1 | 0 | |a EPIDIDYMIS |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a POLYAMINE METABOLISM |
| 690 | 1 | 0 | |a PREPUBERTY |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a SUBCUTANEOUS DRUG ADMINISTRATION |
| 653 | 0 | 0 | |a ici 176334, ICI, United Kingdom |
| 700 | 1 | |a Gonzalez-Calvar, S.I. | |
| 700 | 1 | |a Calandra, R.S. | |
| 773 | 0 | |d Taylor and Francis Ltd., 1997 |g v. 38 |h pp. 163-171 |k n. 2 |p ARCH. ANDROL. |x 01485016 |t Archives of Andrology | |
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| 856 | 4 | 0 | |u https://doi.org/10.3109/01485019708987894 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_01485016_v38_n2_p163_Rulli |y Handle |
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