The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications

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The protozoan Trypanosoma cruzi, its mammalian reservoirs, and vectors have existed in nature for millions of years. The human infection, named Chagas disease, is a major public health problem for Latin America. T. cruzi is genetically highly diverse and the understanding of the population structure...

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Autor principal: Zingales, B.
Otros Autores: Miles, M.A, Campbell, D.A, Tibayrenc, M., Macedo, A.M, Teixeira, M.M.G, Schijman, A.G, Llewellyn, M.S, Lages-Silva, E., Machado, C.R, Andrade, S.G, Sturm, N.R
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2012
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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100 1 |a Zingales, B. 
245 1 4 |a The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications 
260 |c 2012 
270 1 0 |m Zingales, B.; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Avenida Professor Lineu Prestes 748, 05508-000 São Paulo, SP, Brazil; email: zingales@iq.usp.br 
506 |2 openaire  |e Política editorial 
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504 |a Tomasini, N., Lauthier, J.J., Rumi, M.M., Ragone, P.G., D'Amato, A.A., Brandan, C.P., Interest and limitations of spliced leader intergenic region sequences for analyzing Trypanosoma cruzi I phylogenetic diversity in the Argentinean Chaco (2011) Infect. Genet. Evol., 11, pp. 300-307 
504 |a Tomazi, L., Kawashita, S.Y., Pereira, P.M., Zingales, B., Briones, M.R., Haplotype distribution of five nuclear genes based on network genealogies and Bayesian inference indicates that Trypanosoma cruzi hybrid strains are polyphyletic (2009) Genet. Mol. Res., 8, pp. 458-476 
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504 |a Vago, A.R., Andrade, L.O., Leite, A.A., Reis, A.D., Macedo, A.M., Adad, S.J., Genetic characterization of Trypanosoma cruzi directly from tissues of patients with chronic Chagas disease (2000) Am. J. Pathol., 156, pp. 1805-1809 
504 |a Valente, S.A., Valente, V.C., Neves Pinto, A.Y., Barbosa César, M.J., Santos, M.P., Miranda, C.O., Analysis of an acute Chagas disease outbreak in the Brazilian Amazon: human cases, triatomines, reservoir mammals and parasites (2009) Trans. R. Soc.Trop. Med. Hyg., 103, pp. 291-297 
504 |a Virreira, M., Alonso-Vega, C., Solano, M., Jijena, J., Brutus, L., Bustamante, Z., Congenital Chagas disease in Bolivia is not associated with DNA polymorphism of Trypanosoma cruzi (2006) Am. J. Trop. Med. Hyg., 75, pp. 871-879 
504 |a Weatherly, D.B., Boehlke, C., Tarleton, R.L., Chromosome level assembly of the hybrid Trypanosoma cruzi genome (2009) BMC Genomics, 10, p. 255 
504 |a Westenberger, S.J., Barnabé, C., Campbell, D.A., Sturm, N.R., Two hybridization events define the population structure of Trypanosoma cruzi (2005) Genetics, 171, pp. 527-543 
504 |a Westenberger, S.J., Cerqueira, G.C., El-Sayed, N.M., Zingales, B., Campbell, D.A., Sturm, N.R., Trypanosoma cruzi mitochondrial maxicircles display species- and strain-specific variation and a conserved element in the non-coding region (2006) BMC Genomics, 7, p. 60 
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504 |a Yeo, M., Acosta, N., Llewellyn, M., Sanchez, H., Adamson, S., Miles, G.A.J., Origins of Chagas disease: didelphis species are natural hosts of Trypanosoma cruzi I and armadillos hosts of Trypanosoma cruzi II, including hybrids (2005) Int. J. Parasitol., 35, pp. 225-233 
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520 3 |a The protozoan Trypanosoma cruzi, its mammalian reservoirs, and vectors have existed in nature for millions of years. The human infection, named Chagas disease, is a major public health problem for Latin America. T. cruzi is genetically highly diverse and the understanding of the population structure of this parasite is critical because of the links to transmission cycles and disease. At present, T. cruzi is partitioned into six discrete typing units (DTUs), TcI-TcVI. Here we focus on the current status of taxonomy-related areas such as population structure, phylogeographical and eco-epidemiological features, and the correlation of DTU with natural and experimental infection. We also summarize methods for DTU genotyping, available for widespread use in endemic areas. For the immediate future multilocus sequence typing is likely to be the gold standard for population studies. We conclude that greater advances in our knowledge on pathogenic and epidemiological features of these parasites are expected in the coming decade through the comparative analysis of the genomes from isolates of various DTUs. © 2012 Elsevier B.V.  |l eng 
536 |a Detalles de la financiación: Fundação de Amparo à Pesquisa do Estado de São Paulo 
536 |a Detalles de la financiación: National Rosacea Society 
536 |a Detalles de la financiación: 223034 
536 |a Detalles de la financiación: Wellcome Trust 
536 |a Detalles de la financiación: National Institutes of Health, AI056034 
536 |a Detalles de la financiación: Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq 
536 |a Detalles de la financiación: BZ thanks the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) and Ministério de Ciência e Tecnologia/Conselho Nacional de Desenvolvimento Científico e Tecnológico/Ministério da Saúde (MCT/CNPq/MS-SCTIE-DECIT-Edital de Doenças Negligenciadas) for financial support. MAM and MSL thank the Wellcome Trust (UK) and European Union Seventh Program Grant 223034 (ChagasEpiNet) for financial support. DAC and NRS are supported by NIH award AI056034. We thank Michael Lewis and Matthew Yeo for comments on the manuscript. 
593 |a Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Avenida Professor Lineu Prestes 748, 05508-000 São Paulo, SP, Brazil 
593 |a The London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom 
593 |a Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90095-7065, United States 
593 |a Maladies Infectieuses et Vecteurs Ecologie, Génétique, Evolution et Contrôle, MIVEGEC/IDVEGEC, UM1-CNRS 5290-IRD 224, IRD Center, BP 64501, 34394 Montpellier Cedex 5, France 
593 |a Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 486, 30161-970 Belo Horizonte, MG, Brazil 
593 |a Departamento de Parasitologia, Instituto de Biociências, Universidade de São Paulo, Avenida Professor Lineu Prestes 1374, 05508-000 São Paulo, SP, Brazil 
593 |a Laboratorio de Biología Molecular de la Enfermedad de Chagas, INGEBI-CONICET, Vuelto Obligado 2490, Buenos Aires 1428, Argentina 
593 |a Departamento de Ciências Biológicas, Universidade Federal do Triângulo Mineiro, Rua Frei Paulino 30, Uberaba, MG, Brazil 
593 |a Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Rua Waldemar Falcão 121, 40295-001 Salvador, Brazil 
690 1 0 |a DISCRETE TYPING UNIT 
690 1 0 |a GENOTYPING 
690 1 0 |a HYBRIDIZATION 
690 1 0 |a PATHOLOGY 
690 1 0 |a PHYLOGEOGRAPHY 
690 1 0 |a TRYPANOSOMA CRUZI STRAINS 
690 1 0 |a RIBOSOME DNA 
690 1 0 |a CLINICAL FEATURE 
690 1 0 |a DISEASE TRANSMISSION 
690 1 0 |a GENE FREQUENCY 
690 1 0 |a GENETIC VARIABILITY 
690 1 0 |a GENOME ANALYSIS 
690 1 0 |a GENOTYPE 
690 1 0 |a GEOGRAPHIC DISTRIBUTION 
690 1 0 |a HETEROZYGOSITY 
690 1 0 |a HUMAN 
690 1 0 |a MITOCHONDRIAL GENOME 
690 1 0 |a MULTILOCUS SEQUENCE TYPING 
690 1 0 |a NONHUMAN 
690 1 0 |a PHYLOGEOGRAPHY 
690 1 0 |a POPULATION RESEARCH 
690 1 0 |a POPULATION STRUCTURE 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a REVIEW 
690 1 0 |a SINGLE NUCLEOTIDE POLYMORPHISM 
690 1 0 |a TAXONOMY 
690 1 0 |a TRYPANOSOMA CRUZI 
690 1 0 |a ANIMALS 
690 1 0 |a CHAGAS DISEASE 
690 1 0 |a CHIROPTERA 
690 1 0 |a EVOLUTION, MOLECULAR 
690 1 0 |a GENETIC VARIATION 
690 1 0 |a GENOME, PROTOZOAN 
690 1 0 |a GENOMICS 
690 1 0 |a HUMANS 
690 1 0 |a MULTILOCUS SEQUENCE TYPING 
690 1 0 |a PHYLOGEOGRAPHY 
690 1 0 |a TERMINOLOGY AS TOPIC 
690 1 0 |a TRYPANOSOMA CRUZI 
690 1 0 |a MAMMALIA 
690 1 0 |a PROTOZOA 
690 1 0 |a TRYPANOSOMA CRUZI 
700 1 |a Miles, M.A. 
700 1 |a Campbell, D.A. 
700 1 |a Tibayrenc, M. 
700 1 |a Macedo, A.M. 
700 1 |a Teixeira, M.M.G. 
700 1 |a Schijman, A.G. 
700 1 |a Llewellyn, M.S. 
700 1 |a Lages-Silva, E. 
700 1 |a Machado, C.R. 
700 1 |a Andrade, S.G. 
700 1 |a Sturm, N.R. 
773 0 |d 2012  |g v. 12  |h pp. 240-253  |k n. 2  |p Infec. Genet. Evol.  |x 15671348  |w (AR-BaUEN)CENRE-5137  |t Infection, Genetics and Evolution 
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856 4 0 |u https://doi.org/10.1016/j.meegid.2011.12.009  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_15671348_v12_n2_p240_Zingales  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15671348_v12_n2_p240_Zingales  |y Registro en la Biblioteca Digital 
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999 |c 84435 

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