Isolation of acetylated bile acids from the sponge Siphonochalina fortis and DNA damage evaluation by the comet assay
From the organic extracts of the sponge Siphonochalina fortis, collected at Bahia Bustamante, Chubut, Argentina, three major compounds were isolated and identified as deoxycholic acid 3, 12-diacetate (1), cholic acid 3, 7, 12-triacetate (2) and cholic acid, 3, 7, 12-triacetate. (3). This is the firs...
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Elsevier Inc.
2013
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| LEADER | 11601caa a22013337a 4500 | ||
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| 001 | PAPER-24380 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205613.0 | ||
| 008 | 190411s2013 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84884998901 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a STEDA | ||
| 100 | 1 | |a Cano, L.P.P. | |
| 245 | 1 | 0 | |a Isolation of acetylated bile acids from the sponge Siphonochalina fortis and DNA damage evaluation by the comet assay |
| 260 | |b Elsevier Inc. |c 2013 | ||
| 270 | 1 | 0 | |m Bartolotta, S.A.; CIGETOX (Citogenética Humana y Genética Toxicológica), INFIBIOC (Instituto de Fisiopatología y Bioquímica Clínica), Universidad de Buenos Aires (UBA), Junín 956, 1113 CABA Buenos Aires, Argentina; email: susana_bartolotta@yahoo.com.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Carballo, M.A., Lopez Nigro, M., (2006) Genetica Toxicologica., , De Los Cuatro Vientos (Ed.). Buenos Aires, Argentina | ||
| 520 | 3 | |a From the organic extracts of the sponge Siphonochalina fortis, collected at Bahia Bustamante, Chubut, Argentina, three major compounds were isolated and identified as deoxycholic acid 3, 12-diacetate (1), cholic acid 3, 7, 12-triacetate (2) and cholic acid, 3, 7, 12-triacetate. (3). This is the first report of acetylated bile acids in sponges and the first isolation of compound 3 as a natural product. The potential induction of DNA lesions by the isolated compounds was investigated using the comet assay in lymphocytes of human peripheral blood as in vitro model. The results showed that the administration of the bile acid derivatives would not induce DNA damages, indicating that acetylated bile acids are nontoxic metabolites at the tested concentrations. Since the free bile acids were not detected, it is unlikely that the acetylated compounds may be part of the sponge cells detoxification mechanisms. These results may suggest a possible role of acetylated bile acids as a chemical defense mechanism, product of a symbiotic relationship with microorganisms, which would explain their seasonal and geographical variation, and their influence on the previously observed genotoxicity of the organic extract of S. fortis. © 2013 Elsevier Inc. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Manitoba Arts Council | ||
| 536 | |a Detalles de la financiación: Secretaría de Ciencia y Técnica, Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Prog 2011-2014, 20020100100123 | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, PIP N° 516-2009 | ||
| 536 | |a Detalles de la financiación: Research at the University of Buenos Aires was supported by grants from CONICET ( PIP N° 516-2009 ) and UBACYT ( X163 Prog. 2008–2010 ) and 20020100100123 ( Prog 2011-2014 ) awarded to JAP, and by UBACYT (grant 20020100100123 , Prog 2011-2014 ) awarded to MAC. This is INIDEP Contribution N° 1782 . Appendix A | ||
| 593 | |a UMYMFOR, Departamento de Química Orgánica, Universidad de Buenos Aires, Ciudad, Universitaria Pab. 2, 1428 Buenos Aires, Argentina | ||
| 593 | |a CIGETOX (Citogenética Humana y Genética Toxicológica), INFIBIOC (Instituto de Fisiopatología y Bioquímica Clínica), Universidad de Buenos Aires (UBA), Junín 956, 1113 CABA Buenos Aires, Argentina | ||
| 593 | |a Laboratorio de Bentos, Instituto Nacional de Investigación y Desarrollo Pesquero, Paseo Victoria Ocampo 1, B7602HSA Mar del Plata, Argentina | ||
| 690 | 1 | 0 | |a ACETYLATED BILE ACIDS |
| 690 | 1 | 0 | |a BACTERIA |
| 690 | 1 | 0 | |a CHEMICAL DEFENSE |
| 690 | 1 | 0 | |a COMET ASSAY |
| 690 | 1 | 0 | |a DNA DAMAGE |
| 690 | 1 | 0 | |a MARINE SPONGES |
| 690 | 1 | 0 | |a BILE ACID |
| 690 | 1 | 0 | |a CHOLIC ACID 3,7 DIACETATE |
| 690 | 1 | 0 | |a CHOLIC ACID 3,7,12 TRIACETATE |
| 690 | 1 | 0 | |a DEOXYCHOLIC ACID 3,12 DIACETATE |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ACETYLATION |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL VIABILITY |
| 690 | 1 | 0 | |a COMET ASSAY |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DETOXIFICATION |
| 690 | 1 | 0 | |a DNA DAMAGE |
| 690 | 1 | 0 | |a IN VITRO STUDY |
| 690 | 1 | 0 | |a METABOLITE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PERIPHERAL LYMPHOCYTE |
| 690 | 1 | 0 | |a SIPHONOCHALINA FORTIS |
| 690 | 1 | 0 | |a SPONGE (PORIFERA) |
| 690 | 1 | 0 | |a BACTERIA (MICROORGANISMS) |
| 690 | 1 | 0 | |a SIPHONOCHALINA |
| 690 | 1 | 0 | |a ACETYLATED BILE ACIDS |
| 690 | 1 | 0 | |a BACTERIA |
| 690 | 1 | 0 | |a CHEMICAL DEFENSE |
| 690 | 1 | 0 | |a COMET ASSAY |
| 690 | 1 | 0 | |a DNA DAMAGE |
| 690 | 1 | 0 | |a MARINE SPONGES |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a CELL SURVIVAL |
| 690 | 1 | 0 | |a CELLS, CULTURED |
| 690 | 1 | 0 | |a CHOLIC ACIDS |
| 690 | 1 | 0 | |a COMET ASSAY |
| 690 | 1 | 0 | |a DNA DAMAGE |
| 690 | 1 | 0 | |a DRUG EVALUATION, PRECLINICAL |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a LYMPHOCYTES |
| 690 | 1 | 0 | |a MUTAGENS |
| 650 | 1 | 7 | |2 spines |a PORIFERA |
| 700 | 1 | |a Bartolotta, S.A. | |
| 700 | 1 | |a Casanova, N.A. | |
| 700 | 1 | |a Siless, G.E. | |
| 700 | 1 | |a Portmann, E. | |
| 700 | 1 | |a Schejter, L. | |
| 700 | 1 | |a Palermo, J.A. | |
| 700 | 1 | |a Carballo, M.A. | |
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