Repeated methamphetamine and modafinil induce differential cognitive effects and specific histone acetylation and DNA methylation profiles in the mouse medial prefrontal cortex
Methamphetamine (METH) and modafinil are psychostimulants with different long-term cognitive profiles: METH is addictive and leads to cognitive decline, whereas modafinil has little abuse liability and is a cognitive enhancer. Increasing evidence implicates epigenetic mechanisms of gene regulation b...
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| Otros Autores: | , , , , , , , , |
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Elsevier Inc.
2018
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| LEADER | 25308caa a22022937a 4500 | ||
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| 001 | PAPER-25237 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205715.0 | ||
| 008 | 190410s2018 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-85038354526 | |
| 024 | 7 | |2 cas |a DNA, 9007-49-2; histone, 9062-68-4; methamphetamine, 28297-73-6, 51-57-0, 537-46-2, 7632-10-2; modafinil, 68693-11-8; Central Nervous System Stimulants; Histones; Methamphetamine; Modafinil | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a PNPPD | ||
| 100 | 1 | |a González, B. | |
| 245 | 1 | 0 | |a Repeated methamphetamine and modafinil induce differential cognitive effects and specific histone acetylation and DNA methylation profiles in the mouse medial prefrontal cortex |
| 260 | |b Elsevier Inc. |c 2018 | ||
| 270 | 1 | 0 | |m Bisagno, V.; Instituto de Investigaciones Farmacológicas, ININFA-UBA-CONICET, Junín 956, Piso 5, Argentina; email: vbisagno@ffyb.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Agricola, E., Verdone, L., Di Mauro, E., Caserta, M., H4 acetylation does not replace H3 acetylation in chromatin remodelling and transcription activation of Adr1-dependent genes (2006) Mol. Microbiol., 62 (5), pp. 1433-1446 | ||
| 504 | |a Amir, R.E., Van den Veyver, I.B., Wan, M., Tran, C.Q., Francke, U., Zoghbi, H.Y., Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 (1999) Nat. Genet., 23 (2), pp. 185-188 | ||
| 504 | |a Anaclet, C., Parmentier, R., Ouk, K., Guidon, G., Buda, C., Sastre, J.P., Akaoka, H., Lin, J.S., Orexin/hypocretin and histamine: distinct roles in the control of wakefulness demonstrated using knock-out mouse models (2009) J. Neurosci., 29 (46), pp. 14423-14438 | ||
| 504 | |a Anier, K., Malinovskaja, K., Aonurm-Helm, A., Zharkovsky, A., Kalda, A., DNA methylation regulates cocaine-induced behavioral sensitization in mice (2010) Neuropsychopharmacology, 35 (12), pp. 2450-2461 | ||
| 504 | |a Bali, P., Im, H.I., Kenny, P.J., Methylation, memory and addiction (2011) Epigenetics, 6 (6), pp. 671-674 | ||
| 504 | |a Bernheim, A., See, R.E., Reichel, C.M., Chronic methamphetamine self-administration disrupts cortical control of cognition (2016) Neurosci. Biobehav. Rev., 69, pp. 36-48 | ||
| 504 | |a Bisagno, V., González, B., Urbano, F.J., Cognitive enhancers versus addictive psychostimulants: the good and bad side of dopamine on prefrontal cortical circuits (2016) Pharmacol. Res., 109, pp. 108-118 | ||
| 504 | |a Braren, S.H., Drapala, D., Tulloch, I.K., Serrano, P.A., Methamphetamine-induced short-term increase and long-term decrease in spatial working memory affects protein Kinase M zeta (PKMζ), dopamine, and glutamate receptors (2014) Front. Behav. Neurosci., 8, p. 438 | ||
| 504 | |a Cadet, J.L., Bisagno, V., The primacy of cognition in the manifestations of substance use disorders (2013) Front. Neurol., 4, p. 189 | ||
| 504 | |a Cadet, J.L., Brannock, C., Jayanthi, S., Krasnova, I.N., Transcriptional and epigenetic substrates of methamphetamine addiction and withdrawal: evidence from a long-access self-administration model in the rat (2015) Mol. Neurobiol., 51 (2), pp. 696-717 | ||
| 504 | |a Cepeda, C., Levine, M.S., Where do you think you are going? The NMDA-D1 receptor trap (2006) Sci. STKE, 2006 (333), p. pe20 | ||
| 504 | |a Chen, B.T., Yau, H.J., Hatch, C., Kusumoto-Yoshida, I., Cho, S.L., Hopf, F.W., Bonci, A., Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking (2013) Nature, 496 (7445), pp. 359-362 | ||
| 504 | |a Dai, H., Kaneko, K., Kato, H., Fujii, S., Jing, Y., Xu, A., Sakurai, E., Yanai, K., Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors (2007) Neurosci. Res., 57 (2), pp. 306-313 | ||
| 504 | |a Dudman, J.T., Eaton, M.E., Rajadhyaksha, A., Macías, W., Taher, M., Barczak, A., Kameyama, K., Konradi, C., Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1 (2003) J. Neurochem., 87 (4), pp. 922-934 | ||
| 504 | |a Estabrooke, I.V., McCarthy, M.T., Ko, E., Chou, T.C., Chemelli, R.M., Yanagisawa, M., Saper, C.B., Scammell, T.E., Fos expression in orexin neurons varies with behavioral state (2001) J. Neurosci., 21 (5), pp. 1656-1662 | ||
| 504 | |a Ferrucci, M., Giorgi, F.S., Bartalucci, A., Busceti, C.L., Fornai, F., The effects of locus coeruleus and norepinephrine in methamphetamine toxicity (2013) Curr. Neuropharmacol., 11 (1), pp. 80-94 | ||
| 504 | |a Gansen, A., Tóth, K., Schwarz, N., Langowski, J., Opposing roles of H3- and H4-acetylation in the regulation of nucleosome structure—a FRET study (2015) Nucleic Acids Res., 43 (3), pp. 1433-1443 | ||
| 504 | |a Gao, C., Wolf, M.E., Dopamine receptors regulate NMDA receptor surface expression in prefrontal cortex neurons (2008) J. Neurochem., 106 (6), pp. 2489-2501 | ||
| 504 | |a Gentile, T.A., Simmons, S.J., Watson, M.N., Connelly, K.L., Brailoiu, E., Zhang, Y., Muschamp, J.W., Effects of suvorexant, a dual orexin/hypocretin receptor antagonist, on impulsive behavior associated with cocaine (2017) Neuropsychopharmacology | ||
| 504 | |a González, B., Raineri, M., Cadet, J.L., García-Rill, E., Urbano, F.J., Bisagno, V., Modafinil improves methamphetamine-induced object recognition deficits and restores prefrontal cortex ERK signaling in mice (2014) Neuropharmacology, 87, pp. 188-197 | ||
| 504 | |a González, B., Rivero-Echeto, C., Muñiz, J.A., Cadet, J.L., García-Rill, E., Urbano, F.J., Bisagno, V., Methamphetamine blunts Ca(2 +) currents and excitatory synaptic transmission through D1/5 receptor-mediated mechanisms in the mouse medial prefrontal cortex (2016) Addict. Biol., 21 (3), pp. 589-602 | ||
| 504 | |a Gozen, O., Balkan, B., Yildirim, E., Koylu, E.O., Pogun, S., The epigenetic effect of nicotine on dopamine D1 receptor expression in rat prefrontal cortex (2013) Synapse, 67 (9), pp. 545-552 | ||
| 504 | |a Gozzi, A., Colavito, V., Seke Etet, P.F., Montanari, D., Fiorini, S., Tambalo, S., Bifone, A., Bentivoglio, M., Modulation of fronto-cortical activity by modafinil: a functional imaging and fos study in the rat (2012) Neuropsychopharmacology, 37 (3), pp. 822-837 | ||
| 504 | |a Gräff, J., Tsai, L.H., Histone acetylation: molecular mnemonics on the chromatin (2013) Nat. Rev. Neurosci., 14 (2), pp. 97-111 | ||
| 504 | |a Heilig, M., Barbier, E., Johnstone, A.L., Tapocik, J., Meinhardt, M.W., Pfarr, S., Wahlestedt, C., Sommer, W.H., Reprogramming of mPFC transcriptome and function in alcohol dependence (2017) Genes Brain Behav., 16 (1), pp. 86-100 | ||
| 504 | |a Ishizuka, T., Murotani, T., Yamatodani, A., Modanifil activates the histaminergic system through the orexinergic neurons (2010) Neurosci. Lett., 483 (3), pp. 193-196 | ||
| 504 | |a Izquierdo, A., Belcher, A.M., Scott, L., Cazares, V.A., Chen, J., O'Dell, S.J., Malvaez, M., Marshall, J.F., Reversal-specific learning impairments after a binge regimen of methamphetamine in rats: possible involvement of striatal dopamine (2010) Neuropsychopharmacology, 35 (2), pp. 505-514 | ||
| 504 | |a Jayanthi, S., McCoy, M.T., Chen, B., Britt, J.P., Kourrich, S., Yau, H.J., Ladenheim, B., Cadet, J.L., Methamphetamine downregulates striatal glutamate receptors via diverse epigenetic mechanisms (2014) Biol. Psychiatry, 76 (1), pp. 47-56 | ||
| 504 | |a Jin, Q., LR, Y., Wang, L., Zhang, Z., Kasper, L.H., Lee, J.E., Wang, C., Ge, K., Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation (2011) EMBO J., 30 (2), pp. 249-262 | ||
| 504 | |a Kalechstein, A.D., De La Garza, R., II, Newton, T.F., Modafinil administration improves working memory in methamphetamine-dependent individuals who demonstrate baseline impairment (2010) Am. J. Addict., 19 (4), pp. 340-344 | ||
| 504 | |a Kamei, H., Nagai, T., Nakano, H., Togan, Y., Takayanagi, M., Takahashi, K., Kobayashi, K., Yamada, K., Repeated methamphetamine treatment impairs recognition memory through a failure of novelty-induced ERK1/2 activation in the prefrontal cortex of mice (2006) Biol. Psychiatry, 59 (1), pp. 75-84 | ||
| 504 | |a Kauer, J.A., Malenka, R.C., Synaptic plasticity and addiction (2007) Nat. Rev. Neurosci., 8 (11), pp. 844-858 | ||
| 504 | |a Kennedy, P.J., Feng, J., Robison, A.J., Maze, I., Badimon, A., Mouzon, E., Chaudhury, D., Nestler, E.J., Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation (2013) Nat. Neurosci., 16 (4), pp. 434-440 | ||
| 504 | |a Knauber, J., Müller, W.E., Decreased exploratory activity and impaired passive avoidance behaviour in mice deficient for the alpha(1b)-adrenoceptor (2000) Eur. Neuropsychopharmacol., 10 (6), pp. 423-427 | ||
| 504 | |a Kruse, M.S., Prémont, J., Krebs, M.O., Jay, T.M., Interaction of dopamine D1 with NMDA NR1 receptors in rat prefrontal cortex (2009) Eur. Neuropsychopharmacol., 19 (4), pp. 296-304 | ||
| 504 | |a Li, B., Carey, M., Workman, J.L., The role of chromatin during transcription (2007) Cell, 128 (4), pp. 707-719 | ||
| 504 | |a Li, H., Li, F., Wu, N., RB, S., Li, J., Methamphetamine induces dynamic changes of histone deacetylases in different phases of behavioral sensitization (2014) CNS Neurosci. Ther., 20 (9), pp. 874-876 | ||
| 504 | |a Madden, L.J., Flynn, C.T., Zandonatti, M.A., May, M., Parsons, L.H., Katner, S.N., Henriksen, S.J., Fox, H.S., Modeling human methamphetamine exposure in nonhuman primates: chronic dosing in the rhesus macaque leads to behavioral and physiological abnormalities (2005) Neuropsychopharmacology, 30 (2), pp. 350-359 | ||
| 504 | |a Mahler, S.V., Smith, R.J., Moorman, D.E., Sartor, G.C., Aston-Jones, G., Multiple roles for orexin/hypocretin in addiction (2012) Prog. Brain Res., 198, pp. 79-121 | ||
| 504 | |a Martin, T.A., Jayanthi, S., McCoy, M.T., Brannock, C., Ladenheim, B., Garrett, T., Lehrmann, E., Cadet, J.L., Methamphetamine causes differential alterations in gene expression and patterns of histone acetylation/hypoacetylation in the rat nucleus accumbens (2012) PLoS One, 7 (3), p. e34236 | ||
| 504 | |a McGaugh, J., Mancino, M.J., Feldman, Z., Chopra, M.P., Gentry, W.B., Cargile, C., Oliveto, A., Open-label pilot study of modafinil for methamphetamine dependence (2009) J. Clin. Psychopharmacol., 29 (5), pp. 488-491 | ||
| 504 | |a Mereu, M., Bonci, A., Newman, A.H., Tanda, G., The neurobiology of modafinil as an enhancer of cognitive performance and a potential treatment for substance use disorders (2013) Psychopharmacology, 229 (3), pp. 415-434 | ||
| 504 | |a Mieda, M., The roles of orexins in sleep/wake regulation (2017) Neurosci. Res., 118, pp. 56-65 | ||
| 504 | |a Moore, L.D., Le, T., Fan, G., DNA methylation and its basic function (2013) Neuropsychopharmacology, 38 (1), pp. 23-38 | ||
| 504 | |a Moretti, M., Valvassori, S.S., Varela, R.B., Ferreira, C.L., Rochi, N., Benedet, J., Scaini, G., Quevedo, J., Behavioral and neurochemical effects of sodium butyrate in an animal model of mania (2011) Behav. Pharmacol., 22 (8), pp. 766-772 | ||
| 504 | |a Morici, J.F., Bekinschtein, P., Weisstaub, N.V., Medial prefrontal cortex role in recognition memory in rodents (2015) Behav. Brain Res., 292, pp. 241-251 | ||
| 504 | |a Munzar, P., Tanda, G., Justinova, Z., Goldberg, S.R., Histamine h3 receptor antagonists potentiate methamphetamine self-administration and methamphetamine-induced accumbal dopamine release (2004) Neuropsychopharmacology, 29 (4), pp. 705-717 | ||
| 504 | |a Murnane, K.S., Perrine, S.A., Finton, B.J., Galloway, M.P., Howell, L.L., Fantegrossi, W.E., Effects of exposure to amphetamine derivatives on passive avoidance performance and the central levels of monoamines and their metabolites in mice: correlations between behavior and neurochemistry (2012) Psychopharmacology, 220 (3), pp. 495-508 | ||
| 504 | |a Mychasiuk, R., Muhammad, A., Ilnytskyy, S., Kolb, B., Persistent gene expression changes in NAc, mPFC, and OFC associated with previous nicotine or amphetamine exposure (2013) Behav. Brain Res., 256, pp. 655-661 | ||
| 504 | |a Myrick, H., Malcolm, R., Taylor, B., LaRowe, S., Modafinil: preclinical, clinical, and post-marketing surveillance—a review of abuse liability issues (2004) Ann. Clin. Psychiatry, 16 (2), pp. 101-109 | ||
| 504 | |a Committee on guidelines for the use of animals in neuroscience and behavioral research (2003) Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research, , National Academies Press (US) Washington (DC) | ||
| 504 | |a Nestler, E.J., Epigenetic mechanisms of drug addiction (2014) Neuropharmacology, 76, pp. 259-268 | ||
| 504 | |a Parsegian, A., See, R.E., Dysregulation of dopamine and glutamate release in the prefrontal cortex and nucleus accumbens following methamphetamine self-administration and during reinstatement in rats (2014) Neuropsychopharmacology, 39 (4), pp. 811-822 | ||
| 504 | |a Peixoto, L., Abel, T., The role of histone acetylation in memory formation and cognitive impairments (2013) Neuropsychopharmacology, 38 (1), pp. 62-76 | ||
| 504 | |a Rasetti, R., Mattay, V.S., Stankevich, B., Skjei, K., Blasi, G., Sambataro, F., Arrillaga-Romany, I.C., Weinberger, D.R., Modulatory effects of modafinil on neural circuits regulating emotion and cognition (2010) Neuropsychopharmacology, 35 (10), pp. 2101-2109 | ||
| 504 | |a Renthal, W., Kumar, A., Xiao, G., Wilkinson, M., Covington, H.E., III, Maze, I., Sikder, D., Nestler, E.J., Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins (2009) Neuron, 62 (3), pp. 335-348 | ||
| 504 | |a Robison, A.J., Nestler, E.J., Transcriptional and epigenetic mechanisms of addiction (2011) Nat. Rev. Neurosci., 12 (11), pp. 623-637 | ||
| 504 | |a Rogge, G.A., Wood, M.A., The role of histone acetylation in cocaine-induced neural plasticity and behavior (2013) Neuropsychopharmacology, 38 (1), pp. 94-110 | ||
| 504 | |a Romieu, P., Host, L., Gobaille, S., Sandner, G., Aunis, D., Zwiller, J., Histone deacetylase inhibitors decrease cocaine but not sucrose self-administration in rats (2008) J. Neurosci., 28 (38), pp. 9342-9348 | ||
| 504 | |a Sarantis, K., Matsokis, N., Angelatou, F., Synergistic interactions of dopamine D1 and glutamate NMDA receptors in rat hippocampus and prefrontal cortex: involvement of ERK1/2 signaling (2009) Neuroscience, 163 (4), pp. 1135-1145 | ||
| 504 | |a Stertz, L., Fries, G.R., Aguiar, B.W., Pfaffenseller, B., Valvassori, S.S., Gubert, C., Ferreira, C.L., Kauer-Sant'Anna, M., Histone deacetylase activity and brain-derived neurotrophic factor (BDNF) levels in a pharmacological model of mania (2014) Rev. Bras. Psiquiatr., 36 (1), pp. 39-46 | ||
| 504 | |a Stone, E.A., Cotecchia, S., Lin, Y., Quartermain, D., Role of brain alpha 1B-adrenoceptors in modafinil-induced behavioral activity (2002) Synapse, 46 (4), pp. 269-270 | ||
| 504 | |a Strahl, B.D., Allis, C.D., The language of covalent histone modifications (2000) Nature, 403 (6765), pp. 41-45 | ||
| 504 | |a Sulzer, D., Sonders, M.S., Poulsen, N.W., Galli, A., Mechanisms of neurotransmitter release by amphetamines: a review (2005) Prog. Neurobiol., 75 (6), pp. 406-433 | ||
| 504 | |a Torres-García, M.E., Medina, A.C., Quirarte, G.L., Prado-Alcalá, R.A., Differential effects of inactivation of discrete regions of medial prefrontal cortex on memory consolidation of moderate and intense inhibitory avoidance training (2017) Front. Pharmacol., 8, p. 842. , (Nov 17) | ||
| 504 | |a Torres, O.V., McCoy, M.T., Ladenheim, B., Jayanthi, S., Brannock, C., Tulloch, I., Krasnova, I.N., Cadet, J.L., CAMKII-conditional deletion of histone deacetylase 2 potentiates acute methamphetamine-induced expression of immediate early genes in the mouse nucleus accumbens (2015) Sci. Rep., 5, p. 13396 | ||
| 504 | |a Torres, O.V., Ladenheim, B., Jayanthi, S., McCoy, M.T., Krasnova, I.N., Vautier, F.A., Cadet, J.L., An acute methamphetamine injection downregulates the expression of several histone deacetylases (HDACs) in the mouse nucleus accumbens: potential regulatory role of HDAC2 expression (2016) Neurotox. Res., 30 (1), pp. 32-40 | ||
| 504 | |a Wang, Z., Zang, C., Rosenfeld, J.A., Schones, D.E., Barski, A., Cuddapah, S., Cui, K., Zhao, K., Combinatorial patterns of histone acetylations and methylations in the human genome (2008) Nat. Genet., 40 (7), pp. 897-903 | ||
| 504 | |a Wang, Z., Zang, C., Cui, K., Schones, D.E., Barski, A., Peng, W., Zhao, K., Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes (2009) Cell, 138 (5), pp. 1019-1031 | ||
| 504 | |a Warburton, E.C., Brown, M.W., Findings from animals concerning when interactions between perirhinal cortex, hippocampus and medial prefrontal cortex are necessary for recognition memory (2010) Neuropsychologia, 48 (8), pp. 2262-2272 | ||
| 504 | |a Wirt, R.A., Hyman, J.M., Integrating spatial working memory and remote memory: interactions between the medial prefrontal cortex and hippocampus (2017) Brain Sci., 7 (4). , (Apr 18, pii: E43) | ||
| 504 | |a Wisor, J., Modafinil as a catecholaminergic agent: empirical evidence and unanswered questions (2013) Front. Neurol., 4, p. 139 | ||
| 504 | |a Wood, M.A., Attner, M.A., Oliveira, A.M., Brindle, P.K., Abel, T., A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes (2006) Learn. Mem., 13 (5), pp. 609-617 | ||
| 504 | |a Yan, C., Boyd, D.D., Histone H3 acetylation and H3 K4 methylation define distinct chromatin regions permissive for transgene expression (2006) Mol. Cell. Biol., 26 (17), pp. 6357-6371 | ||
| 504 | |a Yu, Q., Olsen, L., Zhang, X., Boeke, J.D., Bi, X., Differential contributions of histone H3 and H4 residues to heterochromatin structure (2011) Genetics, 188 (2), pp. 291-308 | ||
| 504 | |a Zentner, G.E., Henikoff, S., Regulation of nucleosome dynamics by histone modifications (2013) Nat. Struct. Mol. Biol., 20 (3), pp. 259-266 | ||
| 504 | |a Zlomuzica, A., Viggiano, D., De Souza Silva, M.A., Ishizuka, T., Gironi Carnevale, U.A., Ruocco, L.A., Watanabe, T., Dere, E., The histamine H1-receptor mediates the motivational effects of novelty (2008) Eur. J. Neurosci., 27 (6), pp. 1461-1474 | ||
| 520 | 3 | |a Methamphetamine (METH) and modafinil are psychostimulants with different long-term cognitive profiles: METH is addictive and leads to cognitive decline, whereas modafinil has little abuse liability and is a cognitive enhancer. Increasing evidence implicates epigenetic mechanisms of gene regulation behind the lasting changes that drugs of abuse and other psychotropic compounds induce in the brain, like the control of gene expression by histones 3 and 4 tails acetylation (H3ac and H4ac) and DNA cytosine methylation (5-mC). Mice were treated with a seven-day repeated METH, modafinil or vehicle protocol and evaluated in the novel object recognition (NOR) test or sacrificed 4 days after last injection for molecular assays. We evaluated total H3ac, H4ac and 5-mC levels in the medial prefrontal cortex (mPFC), H3ac and H4ac promotor enrichment (ChIP) and mRNA expression (RT-PCR) of neurotransmitter systems involved in arousal, wakefulness and cognitive control, like dopaminergic (Drd1 and Drd2), α-adrenergic (Adra1a and Adra1b), orexinergic (Hcrtr1 and Hcrtr2), histaminergic (Hrh1 and Hrh3) and glutamatergic (AMPA Gria1 and NMDA Grin1) receptors. Repeated METH and modafinil treatment elicited different cognitive outcomes in the NOR test, where modafinil-treated mice performed as controls and METH-treated mice showed impaired recognition memory. METH-treated mice also showed i) decreased levels of total H3ac and H4ac, and increased levels of 5-mC, ii) decreased H3ac enrichment at promoters of Drd2, Hcrtr1/2, Hrh1 and Grin1, and increased H4ac enrichment at Drd1, Hrh1 and Grin1, iii) increased mRNA of Drd1a, Grin1 and Gria1. Modafinil-treated mice shared none of these effects and showed increased H3ac enrichment and mRNA expression at Adra1b. Modafinil and METH showed similar effects linked to decreased H3ac in Hrh3, increased H4ac in Hcrtr1, and decreased mRNA expression of Hcrtr2. The specific METH-induced epigenetic and transcriptional changes described here may be related to the long-term cognitive decline effects of the drug and its detrimental effects on mPFC function. The lack of similar epigenetic effects of chronic modafinil administration supports this notion. © 2017 Elsevier Inc. |l eng | |
| 536 | |a Detalles de la financiación: National Institutes of Health, P30 GM110702 | ||
| 536 | |a Detalles de la financiación: International Society for Neurochemistry | ||
| 536 | |a Detalles de la financiación: University of Arkansas for Medical Sciences | ||
| 536 | |a Detalles de la financiación: This work is supported by grants PICT 2012-0924, PICT 2012-1769, PICT 2014-2499 and PICT 2015-2549, Argentina. In addition, this work was supported by NIH award P30 GM110702 to the Center for Translational Neuroscience, UAMS, USA, and International Society for Neurochemistry CAEN1B grant. | ||
| 593 | |a Instituto de Investigaciones Farmacológicas, Universidad de Buenos Aires – Consejo Nacional de Investigaciones Científicas y Técnicas, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Molecular Neuropsychiatry Research Branch, NIH/NIDA Intramural Research Program, Baltimore, MD, United States | ||
| 593 | |a Department of Behavioral Sciences, San Diego Mesa College, San Diego, CA, United States | ||
| 593 | |a Laboratorio de Fisiología y Biología Molecular, Instituto de Fisiología, Biología Molecular y Neurociencias, Universidad de Buenos Aires – Consejo Nacional de Investigaciones Científicas y Técnicas, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Center for Translational Neuroscience, Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, United States | ||
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| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PROMOTER REGION |
| 690 | 1 | 0 | |a RECOGNITION |
| 690 | 1 | 0 | |a REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION |
| 690 | 1 | 0 | |a WAKEFULNESS |
| 690 | 1 | 0 | |a ACETYLATION |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a C57BL MOUSE |
| 690 | 1 | 0 | |a CHEMICALLY INDUCED |
| 690 | 1 | 0 | |a COGNITION |
| 690 | 1 | 0 | |a DNA METHYLATION |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MEMORY DISORDER |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a PHYSIOLOGY |
| 690 | 1 | 0 | |a PREFRONTAL CORTEX |
| 690 | 1 | 0 | |a ACETYLATION |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a CENTRAL NERVOUS SYSTEM STIMULANTS |
| 690 | 1 | 0 | |a COGNITION |
| 690 | 1 | 0 | |a DNA METHYLATION |
| 690 | 1 | 0 | |a HISTONES |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MEMORY DISORDERS |
| 690 | 1 | 0 | |a METHAMPHETAMINE |
| 690 | 1 | 0 | |a MICE, INBRED C57BL |
| 690 | 1 | 0 | |a MODAFINIL |
| 690 | 1 | 0 | |a PREFRONTAL CORTEX |
| 690 | 1 | 0 | |a RECOGNITION (PSYCHOLOGY) |
| 700 | 1 | |a Jayanthi, S. | |
| 700 | 1 | |a Gomez, N. | |
| 700 | 1 | |a Torres, O.V. | |
| 700 | 1 | |a Sosa, M.H. | |
| 700 | 1 | |a Bernardi, A. | |
| 700 | 1 | |a Urbano, F.J. | |
| 700 | 1 | |a García-Rill, E. | |
| 700 | 1 | |a Cadet, J.-L. | |
| 700 | 1 | |a Bisagno, V. | |
| 773 | 0 | |d Elsevier Inc., 2018 |g v. 82 |h pp. 1-11 |p Prog. Neuro-Psychopharmacol. Biol. Psychiatry |x 02785846 |t Progress in Neuro-Psychopharmacology and Biological Psychiatry | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038354526&doi=10.1016%2fj.pnpbp.2017.12.009&partnerID=40&md5=87d40f816e0264ac0ebadb9a9f71adf3 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.pnpbp.2017.12.009 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_02785846_v82_n_p1_Gonzalez |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02785846_v82_n_p1_Gonzalez |y Registro en la Biblioteca Digital |
| 961 | |a paper_02785846_v82_n_p1_Gonzalez |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 86190 | ||